Chemokine receptor 5 (CCR5) deletion polymorphism in North Indian patients with coronary artery disease

Molecular genetics of atherosclerosis

“…In addition, the I allele of the V249I polymorphism was associated with carotid plaque stability, and the M allele of the CX3CR1 T280M polymorphism has been described as a genetic risk factor for carotid artery occlusive disease (Ghilardi et al 2004). Polymorphisms in other chemokines and chemokine receptors including chemokine receptor (CCR)5, CCR2 (Cha et al 2007;Sharda et al 2008), RANTES (Jang et al 2007) and MCP -1 gene (McDermott et al 2005) have also been associated with atherosclerotic diseases.…”

Emerging role of chemokine CC motif ligand 4 related mechanisms in diabetes mellitus and cardiovascular disease: friends or foes?

“…The CCR5 expression in peripheral monocytes was also increased in obese women [98]. However, another series of clinical investigations found no effects of the CCR5∆32 polymorphism on coronary artery disease or myocardial infarction in other populations [99–102]. Recently, it was shown that no chemokine receptor variant was associated with coronary artery disease, myocardial infarction or glucometabolic traits in large European ancestry cohorts [103].…”

Paraoxonase 1 gene polymorphisms contribute to coronary artery disease risk among north Indians

“…[2] Some of these genes have been examined in Indian populations, including APOE, APOA1, GSTs, ACE, CCR5, TNFα, interleukins and CD14. [7][8][9][10][11][12][13] Paraoxonase 1 (PON1), a calcium-dependent antioxidant glycoprotein, is synthesized in the liver and secreted into the plasma, where it is associated with high density lipoproteins (HDL). Paraoxonase enzyme (EC 3.1.8.1) is implicated in lipid metabolism and in the elimination of carcinogenic lipid-soluble radicals.…”