Chemokine receptor CXCR4 and its ligand CXCL12 expressions and clinical significance in bladder cancer

Yang, Delin; Xin, Mengyang; Wang, J S; Xu, Hongyang; Huo, Qingxiang; Tang, Zhe; Wang, H F

doi:10.4238/2015.december.21.43

Cited by 23 publications

(18 citation statements)

References 15 publications

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“…SDF1 protein has been demonstrated to be associated with increased risk of various kinds of cancers, including breast cancer,31 lung cancer,32 bladder cancer,33 and acute leukemia 1634–37 probably because it could increase the expression of SDF1 protein 19.…”

Section: Discussionmentioning

confidence: 99%

<em>SDF1-</em>3'A polymorphism is associated with increased risk of hematological malignancy: a meta-analysis

Zhang¹,

Yang²,

Li³

2017

OTT

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CXCL12 (also named SDF1), a member of the chemokine family, has been demonstrated to play an important role in the progression of multiple types of hematological malignancy. Several recent studies have shown that SDF1-3′A polymorphism (rs1801157) is associated with susceptibility to hematological malignancy, but published studies’ results are disputed. Therefore, we performed a meta-analysis to evaluate the relationship between SDF1-3′A polymorphism and the risk of hematological malignancy based on the existing literature. We carried out a comprehensive literature search using the Web of Science, PubMed, Cochrane Library, Chinese Wan Fang, and Chinese National Knowledge Infrastructure databases. And the raw data were extracted and calculated in standard steps of meta-analysis. Overall, nine qualified studies containing 1,576 cases and 1,674 controls were included in the ultimate meta-analysis. The pooled results displayed that AA genotype significantly increased the risk of hematological malignancy. The result of subgroup analysis further indicated that SDF1-3′A polymorphism was significantly associated with increased risk of chronic myeloid leukemia, Hodgkin’s lymphoma and multiple myeloma, but was not associated with increased risk of acute myeloid leukemia and non-Hodgkin’s lymphoma. In addition, SDF1-3′A polymorphism was associated with increased risk of hematological malignancy in Africans and Asians, but not in Caucasians. In conclusion, our meta-analysis firstly demonstrated that SDF1-3′A polymorphism may be associated with increased risk of hematological malignancy, especially for chronic myeloid leukemia, Hodgkin’s lymphoma, multiple myeloma and the non-Caucasian population. Nevertheless, these conclusions should be reconfirmed by more evidence from large sample sized studies.

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Section: Discussionmentioning

confidence: 99%

<em>SDF1-</em>3'A polymorphism is associated with increased risk of hematological malignancy: a meta-analysis

Zhang¹,

Yang²,

Li³

2017

OTT

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“…Scientists have recently discovered that the deactivation of chemokines may implicate the initiation or progression of a variety of tumors. [19][20][21] For example, Miyake et al 18 discovered that the higher expression of CXCL1 is associated with the aggressiveness of human BC. Researches have been carried out to reveal the effects of CXCs and CCs on malignant tumors.…”

Section: Introductionmentioning

confidence: 99%

MiR-1-3p inhibits the proliferation and invasion of bladder cancer cells by suppressing CCL2 expression

et al. 2017

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We attempted to analyze the effects of miR-1-3p and CCL2 on the proliferation, migration, and invasion of bladder cancer cells. A total of 18 pairs of bladder cancer tissues with corresponding adjacent tissues and the 6 cases of normal tissues were collected. The expressions of miR-1-3p and CCL2 in the cancer tissues were evaluated using quantitative real-time polymerase chain reaction and western blot. The relationship between miR-1-3p and CCL2 was assessed using luciferase reporter assay. The UM-UC-3 bladder cancer cells were transfected with CCL2 small interfering RNA and miR-1-3p mimics. 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay, colony formation assay, wound healing assay, Transwell assay, and the flow cytometry test were used to detect the proliferation, migration, invasion, and apoptosis of bladder cancer cells. Bladder cancer tissues had lower levels of miR-1-3p but higher levels of CCL2 than normal tissues (p < 0.05). The transfection of miR-1-3p mimics and CCL2 small interfering RNA remarkably suppressed cell proliferation and invasion and promoted apoptosis of cells (p < 0.05). Results of the luciferase reporter gene assay demonstrated that miR-1-3p targeted CCL2. MiR-1-3p suppresses the proliferation and invasion of urinary bladder cancer cells by targeting CCL2.

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“…Similarly, Flt1 promotes the growth and metastasis of tumor cells [24]. In addition, FLT1 can induce tumor metastasis [25]. Moreover, hypermethylated FLT1 plays an important role in chemotherapy resistance [26].…”

Section: Identifi Cation Of Degs and Demsmentioning

confidence: 99%

Identification of biomarkers and potential molecular mechanisms of clear cell renal cell carcinoma

Wu¹,

Wu²,

Gou³

2018

neo

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Clear cell renal cell carcinoma (ccRCC) is the most common type of renal cancer in adults. The aim of this study is to identify the biomarkers and potential molecular mechanisms of ccRCC. Three gene expression profiles and two miRNA expression profiles were downloaded from GEO database. A total of 330 up-regulated differentially expressed genes (DEGs), 545 down-regulated DEGs, 26 up-regulated differentially expressed miRNAs (DEMs) and 11 down-regulated DEMs were identified by GEO2R. The gene ontology (GO) enrichment and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis were performed by KOBAS software. The results showed that GO terms of the up-regulated DEGs were mostly enriched in response to stimulus at BP level, cell periphery at CC level and binding at MF level, while the GO terms of down-regulated DEGs were enriched in single-organism process at BP level, extracellular exosome at CC level and catalytic activity at MF level. As for KEGG pathways, HIF-1 signaling pathway, focal adhesion, PI3K-Akt signaling pathway and metabolic pathways were significantly enriched. Then, protein-protein interaction (PPI) network and miRNA-gene network were constructed and analyzed by Cytoscape. A total of eight DEGs were identified as biomarkers, including VEGFA, PPARA, CCND1, FLT1, CXCL12, FN1, DCN and ERBB4. Expression validation and survival analysis were performed by GEPIA and OncoLnc, respectively. Four biomarkers were verified by quantitative real-time PCR (qPCR) in 786-O cell line and HK-2 cell line. All four genes had the same expression trend as predicted. Our study provides a series of biomarkers and molecular mechanisms for the deeper research of ccRCC.

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Chemokine receptor CXCR4 and its ligand CXCL12 expressions and clinical significance in bladder cancer

Cited by 23 publications

References 15 publications

<em>SDF1-</em>3'A polymorphism is associated with increased risk of hematological malignancy: a meta-analysis

<em>SDF1-</em>3'A polymorphism is associated with increased risk of hematological malignancy: a meta-analysis

MiR-1-3p inhibits the proliferation and invasion of bladder cancer cells by suppressing CCL2 expression

Identification of biomarkers and potential molecular mechanisms of clear cell renal cell carcinoma

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Chemokine receptor CXCR4 and its ligand CXCL12 expressions and clinical significance in bladder cancer

Cited by 23 publications

References 15 publications

<em>SDF1-</em>3&#39;A polymorphism is associated with increased risk of hematological malignancy: a meta-analysis

<em>SDF1-</em>3&#39;A polymorphism is associated with increased risk of hematological malignancy: a meta-analysis

MiR-1-3p inhibits the proliferation and invasion of bladder cancer cells by suppressing CCL2 expression

Identification of biomarkers and potential molecular mechanisms of clear cell renal cell carcinoma

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<em>SDF1-</em>3'A polymorphism is associated with increased risk of hematological malignancy: a meta-analysis

<em>SDF1-</em>3'A polymorphism is associated with increased risk of hematological malignancy: a meta-analysis