Chemokines and their receptors in lung cancer progression and metastasis

Cheng, Zenghui; Shi, Yuxin; Yuan, Min; Xiong, Dan; Zheng, Jianghua; Zhang, Zhiyong

doi:10.1631/jzus.b1500258

Cited by 38 publications

(24 citation statements)

References 82 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Chemokines are key factors in immunological homeostasis [8,9] but also serve as oncogenic activators and/or inhibitors of tumor suppressor gene pathways, and their activities often result in epithelial mesenchymal-transition (EMT), tumor growth, metastasis [10]. However, the mechanisms behind this relationship appear to be complex and poorly understood.…”

Section: Resultsmentioning

confidence: 99%

An assessment of the relationship between the expression of CCR7/CCL19 axis and selected regulatory miRNAs in non-small cell lung cancer

et al. 2019

View full text Add to dashboard Cite

CC chemokine receptor type 7 (CCR7) and its ligands has been implicated in the occurrence and progression of NSCLC. Previous studies have revealed that the diagnostic value of CCR7/CCL19 axis in lung tumorigenesis remains controversial. The present study evaluates the relationship between the mRNA expression of CCR7/CCL19 axis and selected regulatory miRNAs in NSCLC patients. It analyzes the expression level of CCR7 mRNA and its ligand in tumor tissue in relation to expression level of two miRNAs: miR let-7a and miR-335, as transcriptional regulators of study genes. Twenty-seven patients (n = 27) were enrolled. The expression of the studied genes and miRNAs was evaluated by qPCR. Tumour tissue fragments, adjacent macroscopically-unchanged lung tissue (control) and patient serum were used as biological material for study. Elevated expression of CCR7 and CCL19 mRNA was observed in patients with metastasis to lymph nodes. We noticed upregulated miR-335 expression and downregulated miR let-7a expression in patient serum with regard to AJCC tumor staging. Higher miR-335 expression and lower miR let-7a expression level was observed in patients with metastasis to lymph node. The presence of changes observed in the expression level of miR-335 and miR let-7a in the serum of NSCLC patients in relation to lymph node metastases and tumor stage may serve as a non-invasive molecular biomarker of tumor progression; however, this observation requires further investigation.

show abstract

Section: Resultsmentioning

confidence: 99%

An assessment of the relationship between the expression of CCR7/CCL19 axis and selected regulatory miRNAs in non-small cell lung cancer

et al. 2019

View full text Add to dashboard Cite

show abstract

“…Inhibition of the CCR7 gene causes T cells to home to secondary lymphoid organs with signi cantly impaired function [38]. In addition, CXCL1 and CXCL2 have been shown to play a role in the growth of gastric cancer, adenocarcinoma, pancreatic cancer, and melanoma, lung cancer [39,40].…”

Section: Discussionmentioning

confidence: 99%

The prediction of survival and analysis of microenvironment in patients with sarcoma

Chen

Liang

et al. 2020

Preprint

View full text Add to dashboard Cite

Abstract Background: Sarcomas were rare, aggressive, and heterogeneous group of tumors. The degree of tumor microenvironment cells, infiltrating immune cells and stromal cells in the tumor had an important impact on prognosis of sarcoma. The aim of this study was to identify the differentially expressed genes (DEGs) association with immune of sarcoma and potential prognostic immune biomarkers for predicting survival of sarcoma patients. Methods: The gene expression data and clinical data of sarcoma was downloaded from The Cancer Genome Atlas (TCGA) dataset. The immune scores and stromal scores were calculated by ESTIMATE algorithm. The limma package was used to identify the immune DEGs. ClusterProfiler package and STRING were further to analysis the immune DEGs. A prognostic signature was built based the immune gene and clinical data by univariate Cox regression analysis and multivariable Cox analysis. Finally, the prognostic signature was evaluated by functional assessment and the Gene Expression Omnibus (GEO) database. Results: The functional enrichment showed that the up immune DEGs was associated with immune cell activation, proliferation, and adhesion. A single prognostic signature was constructed with seven immune genes, and patient with high risk scores had a worse survival than those with low risk scores. Evaluating showed that the prognostic signature performed well and served as an independent factor in sarcoma. Conclusions: The chemokine receptors or chemokine ligands and immune related genes played a significant role in the mechanism of sarcoma, and the novel immune gene expression had a significant clinical guidance for the prognosis of patient in sarcoma.

show abstract

“…Although the National Comprehensive Cancer Network(NCCN) panel recommended platinum-based chemotherapy regimens as a preferred therapy for patients with NSCLCs, these treatments have many side effects, including fever, anaemia, and alopecia, which have significantly limited their use and decreased patient quality of life [17]. Since metastasis and recurrence are considered to be responsible for the failure of treatments, the mechanism of lung cancer metastasis has been a hot spot in cancer research [18,19]. Therefore, there is an urgent and increasing need to develop effective novel methods or pharmacotherapies to solve this problem.…”

Section: Discussionmentioning

confidence: 99%

Bushenshugan Formula Attenuates the Development of Lung Cancer by Inhibiting Epithelial-Mesenchymal Transition

Fan

Xue

Dou

et al. 2018

Cell Physiol Biochem

View full text Add to dashboard Cite

Background/Aims: BushenShugan Formula (BSF) is a traditional Chinese medicine that has therapeutic effects on middle- and late-stage lung adenocarcinoma in clinical application. It was reported that Bushen Chinese medicine suppressed the onset of pre-metastatic niches in a murine model of spontaneous lung metastasis. However, the mechanisms of BSF on human lung adenocarcinoma remain unknown. Methods: Cell proliferation was determined by CCK8 and colony formation. Cell apoptosis and cell cycle were detected by flow cytometry. Cancer stem cells properties were examined by spheroid body formation. The migration and invasion abilities were analyzed by wound healing assay and transwell invasion assay. The mRNA expressions were determined by qRT-PCR. Western blotting analysis showed the protein levels. Results: BSF was shown to inhibit the proliferation of A549 cells in time- and concentration-dependent manners. Colony formation assays also indicated the antiproliferative effect of BSF against A549 cells. Cellular mechanistic studies demonstrated that BSF arrested the cell cycle in G2/M phase and induced apoptosis. Importantly, BSF could inhibit the epithelial-mesenchymal transition(EMT) of A549 cells through PI3K/AKT/NF-κB pathway. Conclusions: BSF effectively inhibited tumour growth, suggesting that it is a promising anticancer treatment for further clinical development.

show abstract

Chemokines and their receptors in lung cancer progression and metastasis

Cited by 38 publications

References 82 publications

An assessment of the relationship between the expression of CCR7/CCL19 axis and selected regulatory miRNAs in non-small cell lung cancer

An assessment of the relationship between the expression of CCR7/CCL19 axis and selected regulatory miRNAs in non-small cell lung cancer

The prediction of survival and analysis of microenvironment in patients with sarcoma

Bushenshugan Formula Attenuates the Development of Lung Cancer by Inhibiting Epithelial-Mesenchymal Transition

Contact Info

Product

Resources

About