Chemolysis of Struvite Stones by Acidification of Artificial Urine - An in vitro Study

Jacobs, D.

doi:10.1080/003655901753224387

Cited by 29 publications

(5 citation statements)

References 15 publications

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“…To deal with the latter effect, P recovery from waste streams with struvite precipitation is performed within an optimal pH range, generally between 8 and 10 (Liu et al, 2013). The average pH of the runoff water (pH 6.9) in the runoff experiment is only slightly below this range, proving relative stable conditions for a solid struvite phase, whereas more acidic conditions would increase the dissolution rate of the struvite granules ( Jacobs et al, 2001). Since the release of P from struvite to the surface water is related to its dissolution, it is to be expected that this release continues as long as undissolved material is available.…”

Section: Discussionmentioning

confidence: 99%

Limited Dissolved Phosphorus Runoff Losses from Layered Double Hydroxide and Struvite Fertilizers in a Rainfall Simulation Study

et al. 2018

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The enrichment of P in surface waters has been linked to P runoff from agricultural fields amended with fertilizers. Novel slow-release mineral fertilizers, such as struvite and P-exchanged layered double hydroxides (LDHs), have received increasing attention for P recycling from waste streams, and these fertilizers may potentially reduce the risk of runoff losses. Here, a rainfall simulation experiment was performed to evaluate P runoff associated with the application of recycled slow-release fertilizers relative to that of a soluble fertilizer. Monoammonium phosphate (MAP), struvite, and LDH granular fertilizers were broadcasted at equal total P doses on soil packed in trays (5% slope) and covered with perennial ryegrass ( L.). Four rainfall simulation events of 30 min were performed at 1, 5, 15, and 30 d after the fertilizer application. Runoff water from the trays was collected, filtered, and analyzed for dissolved P. For the MAP treatment, P runoff losses were high in the first two rain events and leveled off in later rain events. In total, 42% of the applied P in the MAP treatment was lost due to runoff. In the slow-release fertilizer treatments, P runoff losses were limited to 1.9 (struvite) and 2.4% (LDH) of the applied doses and were more similar over the different rain events. The use of these novel P fertilizer forms could be beneficial in areas with a high risk of surface water eutrophication and a history of intensive fertilization.

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Section: Discussionmentioning

confidence: 99%

Limited Dissolved Phosphorus Runoff Losses from Layered Double Hydroxide and Struvite Fertilizers in a Rainfall Simulation Study

et al. 2018

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“…A couple of studies evaluating the effect of calcium sulphate supplementation in dogs (3.17 g S/kg of diet, Janczikowski et al, 2008) and cats (2.56 g S/kg of diet, Halfen et al, 2018) showed only a small and not significant urinary pH acidification effect, this result might have been due to a low intake of calcium sulphate, which was probably insufficient to produce significant urinary acidification. Multiple studies verified the effectiveness of L-methionine/DL-methionine as a urinary acidifier in humans, cats and dogs (Funaba et al, 2001;Halfen et al, 2018;Hickey et al, 2015;Jacobs et al, 2001;Siener et al, 2016;).…”

Section: Discussionmentioning

confidence: 92%

“…A couple of studies evaluating the effect of calcium sulphate supplementation in dogs (3.17 g S/kg of diet, Janczikowski et al., 2008) and cats (2.56 g S/kg of diet, Halfen et al., 2018) showed only a small and not significant urinary pH acidification effect, this result might have been due to a low intake of calcium sulphate, which was probably insufficient to produce significant urinary acidification. Multiple studies verified the effectiveness of l ‐methionine/ dl ‐methionine as a urinary acidifier in humans, cats and dogs (Funaba et al., 2001; Halfen et al., 2018; Hickey et al., 2015; Jacobs et al., 2001; Siener et al., 2016;). In the present study, urinary pH oscillated between 5.30 and 6.16 when the dogs were fed the Urinary S/O diet, and although the present study was not designed to determine the impact of any specific nutrient on urinary pH, it is expected that the methionine content of this diet had a major influence on its acidifying effect.…”

Section: Discussionmentioning

confidence: 94%

Effects of two commercial diets and two supplements on urinary pH in dogs

Igreja,

Lourenço,

Vernooij

et al. 2023

Veterinary Medicine & Sci

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BackgroundUrinary pH manipulation by therapeutic foods or supplements is part of the treatment for urolithiasis. The effectiveness of these diets and supplements should be studied to determine which of these strategies is most effective.Hypothesis/ObjectivesTo assess the effect of the oral supplementation of potassium citrate, an ammonium chloride solution (Urical) and two dry therapeutic foods—Hill's® Prescription Diet® u/d® Canine (u/d diet) and Royal Canin® Urinary S/O dog (S/O diet)—on a dog's urinary pH at different time points over 8 h.AnimalsSeven healthy adult male research beagle dogs.MethodsA prospective interventional study lasting 31 days. The dogs either received a supplement (potassium citrate or rical) with a dry adult maintenance diet (control diet) or the therapeutic diet (u/d diet or S/O diet). Each treatment had a duration of 2–5 days, with 2‐ to 4‐day washout periods in between. Urinary pH measurements were performed every 2 h between 07h00 and 15h00, with the food being given at 07h00 and 15h00, right after urine collection. The pH measurements obtained in each of the four treatments were compared to control (same dogs fed the control diet exclusively).ResultsWhen compared to the control diet at the same time points, biologically relevant changes in urinary pH (defined as ≥0.5) were: increase with potassium citrate at 7h00 and 13h00; increase with u/d diet at 9h00, 13h00, and 15h00; decrease with S/O diet at 9h00 and 11h00; Urical did not have a detectable effect on urinary pH.Conclusions and Clinical ImportanceThe present study confirms that therapeutic foods S/O and u/d, and potassium citrate supplement affected acid‐base balance in healthy adult male beagle dogs, with the tested diets being more effective than the administered doses of the tested supplements at influencing urinary pH.

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“…A goal for controlling phosphatic urolithiasis is to, at least periodically, reduce the urine pH below 6.5, the target pH for dissolution. 26,27 This can be done in a variety of ways, including reducing the DCAD of the total diet to 0 mg/kg using chloride salts. 28,29 D, L methionine at a dosage of 200mg/kg orally daily has been shown to effectively reduce urine pH.…”

Section: Preventive Managementmentioning

confidence: 99%

Winning strategies against urolithiasis

Jones Cook

2023

AABP Proceedings

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Urolithiasis is a multifactorial disease of male ruminants causing significant economic loss and compromise of animal welfare. Known risk factors include anatomic factors, urine pH, water intake, dietary composition and genetic factors. Clinical cases of obstructive urolithiasis may be treated using a variety of medical and surgical interventions, including tube cystostomy, perineal urethrostomy, urinary bladder marsupialization and modifications of these procedures designed to optimize patient outcome. Preventative measures aimed at the known risk factors include addressing body water balance, mineral composition of the diet and anatomical factors.

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Chemolysis of Struvite Stones by Acidification of Artificial Urine - An in vitro Study

Abstract: The acidification of urine accelerated the dissolution rate of struvite stones in vitro. Considering in vivo conditions the intake of 1,500-3,000 mg L-methionine may lead to a sufficient acidification for a good dissolution of struvite stones.

Cited by 29 publications

References 15 publications

Limited Dissolved Phosphorus Runoff Losses from Layered Double Hydroxide and Struvite Fertilizers in a Rainfall Simulation Study

Limited Dissolved Phosphorus Runoff Losses from Layered Double Hydroxide and Struvite Fertilizers in a Rainfall Simulation Study

Effects of two commercial diets and two supplements on urinary pH in dogs

Winning strategies against urolithiasis

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