Chemomechanical preparation influences the microbial community and the levels of LPS, LTA and cytokines in combined endodontic‐periodontal lesions: A clinical study

Gomes, Brenda Paula Figueiredo de Almeida; Berber, Vanessa Bellocchio; Marinho, Ariane Cássia Salustiano; Louzada, Lidiane Mendes; Arruda‐Vasconcelos, Rodrigo; Passini, Maicon Ricardo Zieberg; Lopes, Érica Mendes; Pecorari, Vanessa Gallego Arias; Chen, Tsute; Paster, Bruce J.

doi:10.1111/jre.12964

Cited by 7 publications

(3 citation statements)

References 61 publications

(127 reference statements)

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“…Furthermore, retrospective studies do not comment on the influence of periodontal status either, perhaps as it has no obvious effect or because it was not the focus of the study (Kunert et al, 2015; Linsuwanont et al, 2017). Recent research has highlighted the presence of raised inflammatory cytokines in the pulp tissue of patients with advanced periodontal disease (Gomes et al, 2022), so it is ostensibly possible, but as yet untested that periodontal disease may influence the outcome of pulpotomy.…”

Section: Reviewmentioning

confidence: 99%

Factors that influence the outcome of pulpotomy in permanent teeth

et al. 2022

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The promotion of minimally invasive treatments focussed on the maintenance of pulp vitality has become a priority area in Endodontics. These vital pulp treatments (VPT) include partial and full pulpotomy, during which diseased coronal pulp tissue is removed prior to placement of a capping biomaterial and restoration. Traditionally, pulpotomies were confined to the treatment of carious primary and traumatized permanent teeth. However, these treatments have now been proposed as definitive solutions for cariously exposed permanent teeth with mild symptoms or even symptoms indicative of irreversible disease. Until recently, it was recommended that carious exposure of mature permanent teeth be managed by root canal treatment. The promotion of pulpotomy as an alternative treatment has opened up a wave of laboratory and clinical research aimed at improving therapies or evaluating clinical outcomes.In modern evidence-based endodontics, it is imperative that the outcomes of both partial and full pulpotomy are considered and important prognostic factors identified, so that improvements can be made to aid clinical decision-making and to direct new research. In this narrative review, the outcomes of partial and full pulpotomy are discussed, before analysis of patient, intraoperative and postoperative factors that influence the outcome of the pulpotomy procedure. The review highlights that although partial and full pulpotomy for the treatment of even pulpal disease are highly successful procedures, this is based on low-quality evidence with a lack of prospective, comparative trials investigating potential prognostic factors. Based on current evidence, it appears that age, gender, tooth type, root development and intraoperative pulpal haemorrhage do not impact significantly on pulpotomy outcome, whilst others such as caries depth, inflammatory status of the pulp, capping material, level of inflammatory pulpal-biomarkers and the final restoration integrity do. Other factors, including the influence of exposure type, periodontal condition, pulpal lavage, magnification, operator experience, isolation of the operating field and type of pulpotomy, require further experimental investigation before definitive conclusions can be made relating to the success of the pulpotomy procedure. Finally, there is not only a need for future well-designed prospective research addressing these issues but also

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Section: Reviewmentioning

confidence: 99%

Factors that influence the outcome of pulpotomy in permanent teeth

et al. 2022

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“…Upper respiratory infections, intestinal infections, and renal calculi are all treated with Ocimum sanctum Linn [ 19 ]. One of the most effective methods for disinfecting the canals and controlling pain is to place biocompatible drugs that have either a potent antibacterial component or an anti-inflammatory component, or both, into the root canals [ 20 ]. In this present study both the experimental groups had higher antioxidant activity than the control group based on DPPH and Nitric oxide assays.…”

Section: Discussionmentioning

confidence: 99%

Antioxidant and anti-inflammatory activity of a nanoparticle based intracanal drugs

Nasim¹

2022

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The most common intracanal medication is calcium hydroxide. Its efficacy can be affected by a number of factors, including pH, serum proteins, collagen, and dentin. It's also ineffective against E. faecalis and fungus, lacks an anti-inflammatory component, and has mixed reviews when it comes to pain relief. Natural alternatives to synthetic intracanal medication are being researched at the moment. We evaluated the antioxidant and anti-inflammatory activity of green synthesized silver nanoparticle based intracanal medicaments. Silver nanoparticles integrated into calcium hydroxide and graphene oxide nanoparticles were the experimental groups and Calcium hydroxide served as the control. Antioxidant activity was determined using the DPPH and Nitric oxide assays, while anti-inflammatory activity was determined using the protein denaturation and Xanthine Oxidase Inhibition assays. Both experimental groups had higher antioxidant activity than the control group based on DPPH and Nitric oxide assays. Calcium hydroxide combined with silver nanoparticles demonstrated improved anti-inflammatory efficacy in a protein denaturation and Xanthine oxidase inhibition assay. Within the constraints of an in vitro study, it can be concluded that intracanal medicaments containing silver nanoparticles can be employed efficiently during root canal preparation. In comparison to standard calcium hydroxide-based intracanal medicaments, it has effective antioxidant and anti-inflammatory effects.

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“…These and other basic studies on the interactions between the immune system and bone following pulpal infections have been important in establishing the field of osteoimmunology. These basic studies have provided a rationale of clinical research on IL-1/IL-1 signaling in AP and foundation for interpreting their outcomes (16)(17)(18)(19)(20)(21)(22).…”

Section: Introductionmentioning

confidence: 99%

Revisiting the role of IL-1 signaling in the development of apical periodontitis

et al. 2022

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Apical periodontitis (AP) develops as a result of an immune response to pulpal bacterial infection, and various cytokines are involved in the pathogenesis of AP, with Interleukin (IL)-1 being considered a key cytokine. The role of IL-1 in the pathogenesis of AP has been well studied. It is known that IL-1 expression in periapical lesions correlates closely with the development of AP. IL-1 is a potent bone-resorptive cytokine that induces osteoclast formation and activation. Hence, inhibiting its signaling with IL-1 receptor antagonist (IL-1RA) results in a reduction in periapical lesion size. On the other hand, IL-1 is also a central cytokine that combats bacterial infection by activating innate immune responses. Therefore, a complete loss of IL-1 signaling leads to a failure to limit bacterial dissemination and consequently exacerbates AP. In vivo, IL-1 expression is tightly regulated and its signaling is modulated to optimize the immune response. Obesity causes systemic low-grade chronic inflammation and increases the risk of cardiovascular, renal, and other disorders. In experimentally induced AP, obesity significantly increases periapical bone loss, albeit the underlying mechanism remains unclear. Recent technological innovations have enabled more comprehensive and detailed analyses than previously, leading to new insights into the role of IL-1RA in regulating IL-1 signaling, and modulating apical lesion progression in obesity. In this review, we provide a brief overview of the function of IL-1 in AP development, with special emphasis on the latest findings in normal weight and obese states.

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Chemomechanical preparation influences the microbial community and the levels of LPS, LTA and cytokines in combined endodontic‐periodontal lesions: A clinical study

Cited by 7 publications

References 61 publications

Factors that influence the outcome of pulpotomy in permanent teeth

Factors that influence the outcome of pulpotomy in permanent teeth

Antioxidant and anti-inflammatory activity of a nanoparticle based intracanal drugs

Revisiting the role of IL-1 signaling in the development of apical periodontitis

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