Chemometric analysis of correlations between electronic absorption characteristics and structural and/or physicochemical parameters for ampholytic substances of biological and pharmaceutical relevance

Judycka-Proma, Urszula; Bober, Leszek; Gajewicz, Agnieszka; Puzyn, Tomasz; Błażejowski, Jerzy

doi:10.1016/j.saa.2014.11.067

Cited by 3 publications

(3 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Detailed information on the sources of the target compounds is provided in our recent works [17,19,20].…”

Section: Chemicalsmentioning

confidence: 99%

“…Detailed information concerning the physicochemical and spectral characteristics of the investigated compounds used i n c h e m o m e t r i c a n a l y s i s i s g i v e n i n Ta b l e 3 S (Supplementary materials) [17,19,20]. The values of these characteristics are compiled in Table 4S (Supplementary materials).…”

Section: Physicochemical and Spectral Characteristicsmentioning

confidence: 99%

“…The compounds investigated are natural and synthetic amino acids, pseudo-amino acids (containing an amino group in the chain or in a ring), sulphanilic acid, and its derivatives (sulphonamides) and derivatives of fluoroquinone and purine [17,19,20]. Among these compounds are precursors of biologically interesting peptides or proteins, others are important as vitamins or valuable pharmaceuticals.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Chemometric outlook on correlations between retention parameters of polar and semipolar HPLC columns and physicochemical characteristics of ampholytic substances of biological and pharmaceutical relevance

et al. 2018

View full text Add to dashboard Cite

The Quantitative Property-Retention Relation (QPRR) approach was applied to analyze the correlations between the retention parameters of ampholytic, biologically active substances and their physicochemical (predicted/spectral) characteristics. The retention parameters were obtained for polar and semipolar HPLC columns at various compositions of mobile phases and pH conditions. These values are a unique collection of chromatographic parameters that are a measure of lipophilicity and, consequently, can be very helpful in assessing pharmacological potency of the compounds investigated. Three QPRR models that meet the predictive capability criteria were developed. The relationships can be used to gain pharmacologically interesting information on the biologically active ampholytic substances.

show abstract

“…Detailed information on the sources of the target compounds is provided in our recent works [17,19,20].…”

Section: Chemicalsmentioning

confidence: 99%

Section: Physicochemical and Spectral Characteristicsmentioning

confidence: 99%