Chemometric and Experimental Investigations of Organogelation Based on β-Cyclodextrin

Abstract

The evaluation of PEG as a gelation solvent for an organogel based on β-cyclodextrin (β-CyD) was investigated using principal component analysis (PCA). The test tube tilting method was performed to examine the gel formation experimentally. The important descriptors used in the PCA included the Hansen partial solubility parameters. LogP may be able to be used as an additional descriptor for this system. According to PCA analysis, PEG was in a cluster of gelation solvents. Subsequently, various PEG liquid state grades were tested for their ability to gel the system and PEG400 was found to be able to produce a gel. This verifies that PCA can be successfully used to evaluate the role of PEG. Accordingly, this PCA method may be an effective tool to evaluate the role of any solvent for other low molecular weight gelators (LMWGs). Afterwards, the optimal components in the system were explored, and it was found to be 0.1M β-CyD, 0.5M K2CO3 in PEG400. Based on WAXS, the gel fiber of this organogel was demonstrated to be amorphous. This forming organogel will be further characterized in details and investigated for use in a drug delivery system.

Biocompatible Polymers Combined with Cyclodextrins: Fascinating Materials for Drug Delivery Applications

“…There is only one example of gels composed of the PEG and CD for the diclofenac delivery [146]. The gels were prepared with a concentration of 0.1 M β-CD and 0.54 M K 2 CO 3 in PEG400, respectively [160]. The occurrence of the gelation was ascribed to the formation of PPRXs supramolecular structure.…”

Characterization of supramolecular gels based on β-cyclodextrin and polyethyleneglycol and their potential use for topical drug delivery

“…The appropriate ratio of β-CD and K 2 CO 3 in PEG to form a gel has been investigated and reported elsewhere [15]. Accordingly, the concentrations of β-CD and K 2 CO 3 that were used in this study were 0.1 M and 0.54 M, respectively.…”

“…Consequently, the stress of 1 Pa that lies within the LVR was employed in all measurements. According to the test tube tilting method (reported elsewhere) [15], we detected two gel types for these samples. One type of the gel (Gel L ) was formed at a low temperature (below 50°C) and the other (Gel H ) was formed at a higher temperature (above 70°C).…”

“…Therefore, the gel produced using both materials should be feasible for drug delivery. According to our preliminary study [15], β-CD can form a gel with PEG400 (a liquid form of PEG) in the presence of K 2 CO 3 . Since PEG instead of water has been employed as the medium, the gel may be referred to as an organogel.…”