Chemometric Methods for the Quantification of Crystalline Tacrolimus in Solid Dispersion by Powder X‐Ray Diffractrometry

Siddiqui, Akhtar; Rahman, Ziyaur; Bykadi, Srikant; Khan, Mansoor A.

doi:10.1002/jps.23912

Cited by 27 publications

(14 citation statements)

References 21 publications

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“…Consequently, the use of XRD in combination with PCA is a promising method for studying the crystallinity of NC formulations during aging. These findings confirm the efficiency of XRD coupled to chemometrics to investigate several properties of various materials …”

Section: Discussionsupporting

confidence: 80%

Differentiation of stabilized nitrocellulose during artificial aging: Spectroscopy methods coupled with principal component analysis

Trache

Tarchoun

2019

Journal of Chemometrics

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In this work, Fourier transform infrared spectroscopy (FTIR) and X-ray powder diffraction (XRD) were selected as reliable, fast, and nondestructive techniques to assess their potentialities for characterization and discrimination of nitrocellulose (NC)-based formulations containing different kinds of stabilizers and subjected to accelerated aging. Preliminary results based on visual comparison of the spectra point out that spectra obtained by both spectroscopic techniques were useful for a rapid detection of the aging process without additional sample preparation. Additionally, the existence of compatibility issues between NC and one of the stabilizers is easily recognized. The spectral data were subjected to principal component analysis (PCA) for visualization and to reveal differences between samples. The obtained results demonstrated that PCA plots were able to distinguish and classify the NC samples with respect to their respective stabilizers and aging.

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Section: Discussionsupporting

confidence: 80%

Differentiation of stabilized nitrocellulose during artificial aging: Spectroscopy methods coupled with principal component analysis

Trache

Tarchoun

2019

Journal of Chemometrics

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“…These models were applied to quantitate different forms of the tacrolimus in the samples. This investigation was the extension of our previous works on immediate‐release tacrolimus ASD …”

Section: Introductionmentioning

confidence: 79%

“…This investigation was the extension of our previous works on immediate-release tacrolimus ASD. 21,22…”

Section: Introductionmentioning

confidence: 99%

Near-Infrared and Fourier Transform Infrared Chemometric Methods for the Quantification of Crystalline Tacrolimus from Sustained-Release Amorphous Solid Dispersion

Rahman

Siddiqui

Bykadi

et al. 2014

Journal of Pharmaceutical Sciences

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“…Powder X-ray diffraction (XRPD) is a well-recognized technique for evaluating solid state property of the drug (Siddiqui, 2014). In case of amorphous drug, XRPD produces halo due to absence of crystal lattice.…”

Section: Introductionmentioning

confidence: 99%

Development and validation of X-ray diffraction method for quantitative determination of crystallinity in warfarin sodium products

Siddiqui

Rahman

Korang-Yeboah

et al. 2015

International Journal of Pharmaceutics

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Chemometric Methods for the Quantification of Crystalline Tacrolimus in Solid Dispersion by Powder X‐Ray Diffractrometry

Cited by 27 publications

References 21 publications

Differentiation of stabilized nitrocellulose during artificial aging: Spectroscopy methods coupled with principal component analysis

Differentiation of stabilized nitrocellulose during artificial aging: Spectroscopy methods coupled with principal component analysis

Near-Infrared and Fourier Transform Infrared Chemometric Methods for the Quantification of Crystalline Tacrolimus from Sustained-Release Amorphous Solid Dispersion

Development and validation of X-ray diffraction method for quantitative determination of crystallinity in warfarin sodium products

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