The paper reports application of X-ray fluorescence (XRF) procedure to determine the contents of 17 elements (Na, Mg, Al, Si, P, S, Cl, K, Ca, Mn, Fe, Ni, Cu, Zn, Rb, Sr, and Zr) in a dry residue of cow milk. The main advantages of this procedure imply: preparation of samples without having them destructed, use of plant reference samples (RS) to calibrate, no need for milk defatting, and, as a consequence, no limitations for the milk fatness. The tendencies identified with the XRF results on the dry residue of cow milk do not contradict the features recognized in environmental biogeochemistry. They designate a satisfactory quality of XRF results and prove them promising for multipurpose interpretations.