Chemoprevention by isothiocyanates and their underlying molecular signaling mechanisms

Watercress supplementation in diet reduces lymphocyte DNA damage and alters blood antioxidant status in healthy adults

“…In terms of the active chemical species, CVs are rich sources of glucosinolates, a class of sulfur-and nitrogen-containing glycosides that are hydrolyzed (by plant myrosinase or intestinal microflora) to form isothiocyanates. These isothiocyanates have been shown, in several in vitro and in vivo studies, to display anticarcinogenic properties as reviewed previously (9,17). Watercress (Rorippa nasturtium-aquaticum) in particular contains one of the highest concentrations of glucosinolates per gram weight of any vegetable (18,19) as well as containing high concentrations of carotenoids such as lutein and ␤-carotene (20).…”

Identification and quantification of glucosinolates in Korean leaf mustard germplasm (Brassica juncea var. integrifolia) by liquid chromatography–electrospray ionization/tandem mass spectrometry

“…Intact GSLs are nontoxic; however, upon tissue damage (e.g., by cutting or chewing), they come into contact with myrosinases and are hydrolyzed into unstable aglycones, which rearrange into a range of bioactive products and sometimes toxic compounds including isothiocyanates, thiocyanates, nitriles, oxazolidine-2-thiones, or epithioalkanes [2]. Although certain GSLs derivatives have anti-nutritional properties [25], it is now well established that methioninederived isothiocyanates can offer substantial protection against cancer [18].…”

A bél–máj tengely vizsgálata colitis ulcerosában. Retrospektív tanulmány

“…A makrorostanyagok fogyasztása gyakran okoz kellemetlen panaszokat IBD-ben, így bizonyos élelmiszerek kerülésére kényszerítik a betegeket [9,10] (például ká-posztafélék, hüvelyesek, teljes kiőrlésű gabonafélék), ezzel is csökkentve a táplálkozással bevihető fontos bioaktív anyagok felvételét, mint például az izotiocianátokét, amelyek az Nrf-2-ARE útvonalon történő fázis II enzim indukciókért felelősek, és az enzimatikus véde-kezés felerősítését végzik [26]. Az izotiocianátok az NF-kappaB sejtmagba jutását gátolva a sejteket védik a tumoros elfajulástól [27].…”