Chemoprevention by lycopene of mouse lung neoplasia after combined initiation treatment with DEN, MNU and DMH

Kim, Dae Joong; Takasuka, Nobuo; Kim, Jin Man; Sekine, Kazunori; Ota, Tomohiro; Asamoto, Makoto; Murakoshi, Michiaki; Nishino, Hoyoku; Nir, Z.; Tsuda, Hiroyuki

doi:10.1016/s0304-3835(97)00281-4

Cited by 77 publications

(34 citation statements)

References 25 publications

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“…Feed containers for mice were refilled with fresh lycopene diet twice a week. The doses of EGCG and lycopene in the present study are comparable to those in previous studies in which these compounds inhibited chemically induced and spontaneous mouse tumorigenesis 16,17) . All the mice were killed by anesthesia at 18 months of age, and a complete autopsy was performed.…”

Section: Effects Of Egcg and Lycopene On Spontaneous Liver Tumorsupporting

confidence: 89%

“…An important question that requires attention is why EGCG and lycopene did not inhibit spontaneous liver tumorigenesis in C3H/HeN mice in the present study, although these compounds have been previously reported to inhibit the formation of various carcinogen -induced tumors [13][14][15][16] . The concentration of EGCG and lycopene in the present study was comparable to that used in previous studies in which these compounds inhibited chemically induced tumorigenesis.…”

Section: Discussioncontrasting

confidence: 51%

“…Lycopene is known to possess high singlet oxygen -quenching capability 12) . Although EGCG and lycopene have been reported to inhibit the formation of carcinogeninduced tumors in various animal models [13][14][15][16] , only a few studies have examined the inhibitory effects of these compounds on spontaneous liver tumorigenesis in rodents 17,18) . Male C3H mice exhibit high susceptibility to spontaneous and chemically induced hepatotumorigenesis ; these mice spontaneously develop liver tumors late in their life, with an incidence as high as 70% 19) .…”

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confidence: 99%

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NO INHIBITORY EFFECTS OF (-)-EPIGALLOCATECHIN GALLATE AND LYCOPENE ON SPONTANEOUS HEPATOTUMORIGENESIS IN C3H/HeN MICE

Takahashi

Hara

Imanaka

et al. 2010

Fukushima J. Med. Sci.

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: Although several studies have indicated that (-) -epigallocatechin gallate (EGCG) and lycopene, representative dietary antioxidants, inhibit chemically induced animal tumorigenesis, only a few studies have examined the inhibitory effects of these compounds on spontaneous liver tumorigenesis in rodents. In this study, we investigated the inhibitory effects of these compounds on the formation of spontaneous liver tumors in C3H/HeN mice. We used xeroderma pigmentosum group A (XPA) gene -deficient mice to simultaneously examine whether the knockout mice could be used as a sensitive animal model. In addition, we examined the levels of 8 -hydroxy -2´-deoxyguanosine (8 -OHdG) -a marker of reactive oxygen species -induced DNA injury -in liver tissue. Male XPA +/+, XPA +/-, and XPA -/-mice with a C3H/HeN genetic background were divided into 3 groups : control, EGCG, and lycopene. Autopsy at 18 months of age revealed that EGCG and lycopene did not exhibit obvious suppressive effects on the development of liver tumors in any XPA genotype ; further, the XPA genotype did not influence any susceptibility to liver tumors. With regard to 8 -OHdG levels in non -tumorous liver tissue at 8 months of age, EGCG showed no significant inhibitory effects and lycopene showed significant inhibitory effects only in XPA +/- mice. The present study demonstrates that contrary to previous reports of the inhibitory effects of EGCG and lycopene on the development of various carcinogeninduced animal tumors, these compounds exert no chemopreventive effects on spontaneous liver tumorigenesis in C3H/HeN mice. EGCG and lycopene may inhibit carcinogen -induced tumors through properties other than their antioxidant abilities.

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Section: Effects Of Egcg and Lycopene On Spontaneous Liver Tumorsupporting

confidence: 89%

Section: Discussioncontrasting

confidence: 51%

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confidence: 99%

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NO INHIBITORY EFFECTS OF (-)-EPIGALLOCATECHIN GALLATE AND LYCOPENE ON SPONTANEOUS HEPATOTUMORIGENESIS IN C3H/HeN MICE

Takahashi

Hara

Imanaka

et al. 2010

Fukushima J. Med. Sci.

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“…27) Intraperitoneal injection of lycopeneenriched tomato extract reduced 7,12-dimethylbenz-[a]anthracene-induced mammary tumors in rats, 28) and the ingestion of lycopene-containing drinking water decreased carcinogen-induced lung tumors in male B6C3F1 mice. 29) Recent reports showed that 25 ppm lycopene solution and diluted tomato juice (25 ppm lycopene) given as drinking water reduced N-butyl-N-(4-hydroxybutyl)nitrosamine-induced urinary bladder cancer in rats, though tomato juice was much more effective than lycopene. 30,31) It is noteworthy that the results are consistent with our results in the present study.…”

Section: Discussionmentioning

confidence: 99%

Prevention of N‐Methylnitrosourea‐induced Colon Carcinogenesis in F344 Rats by Lycopene and Tomato Juice Rich in Lycopene

Narisawa

Fukaura

Hasebe

et al. 1998

Japanese Journal of Cancer Research

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Epidemiological studies have suggested a protective effect of lycopene and lycopene-rich tomatoes against various cancers. Here, the inhibition of colon carcinogenesis by lycopene and tomato juice was investigated. Seven-week-old female F344/NSlc rats received an intrarectal dose of 2 mg (experiment I) or 4 mg (experiment II) of N-methylnitrosourea 3 times a week for 3 weeks, and had free access to one of 4 drinking fluids: plain water (control group), 17 ppm lycopene water solution (Ly group), and diluted tomato juice containing 17 ppm (Tj group) or 3.4 ppm (tj group) lycopene, throughout the experiments. The colon cancer incidence at week 35 was significantly lower in the Tj group, but not in the Ly group, than in the control group: 21% and 33% vs. 54%, in experiment I (24 rats in each group). It was significantly lower in the Tj group than in the tj and control groups, 40% vs. 72% and 84%, in experiment II (25 rats in each group). An appreciable amount of lycopene (0.02 µ µ µ µg/g) was detected in the colon mucosa of rats in the Tj group, but not in the tj group. The results suggest that tomato juice rich in lycopene may have a protective effect against colon carcinogenesis.

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“…Giovannucci reviewed data from clinical and epidemiological studies and found that most of these studies show an inverse association between tomato intake or blood lycopene level and the risk of cancer . These epidemiological data are reinforced by studies showing the inhibitory e ect of lycopene on tumor cell growth in vitro (Amir et al, 1999;Countryman et al, 1991; and in vivo (Kim et al, 1997;Kobayashi et al, 1996;Nagasawa et al, 1995;Narisawa et al, 1996;Sharoni et al, 1997;.…”

Section: Introductionmentioning

confidence: 96%

Lycopene inhibition of cell cycle progression in breast and endometrial cancer cells is associated with reduction in cyclin D levels and retention of p27Kip1 in the cyclin E–cdk2 complexes

et al. 2001

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Numerous studies have demonstrated the anticancer activity of the tomato carotenoid, lycopene. However, the molecular mechanism of this action remains unknown. Lycopene inhibition of human breast and endometrial cancer cell growth is associated with inhibition of cell cycle progression at the G 1 phase. In this study we determined the lycopene-mediated changes in the cell cycle machinery. Cells synchronized in the G 1 phase by serum deprivation were treated with lycopene or vehicle and restimulated with 5% serum. Lycopene treatment decreased serum-induced phosphorylation of the retinoblastoma protein and related pocket proteins. This e ect was associated with reduced cyclin-dependent kinase (cdk4 and cdk2) activities with no alterations in CDK protein levels. Lycopene caused a decrease in cyclin D1 and D3 levels whereas cyclin E levels did not change. The CDK inhibitor p21 Cip1/Waf1 abundance was reduced while p27 Kip1 levels were unaltered in comparison to control cells. Serum stimulation of control cells resulted in reduction in the p27 content in the cyclin E ± cdk2 complex and its accumulation in the cyclin D1 ± cdk4 complex. This change in distribution was largely prevented by lycopene treatment. These results suggest that lycopene inhibits cell cycle progression via reduction of the cyclin D level and retention of p27 in cyclin E ± cdk2, thus leading to inhibition of G 1 CDK activities. Oncogene (2001) 20, 3428 ± 3436.

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Chemoprevention by lycopene of mouse lung neoplasia after combined initiation treatment with DEN, MNU and DMH

Cited by 77 publications

References 25 publications

NO INHIBITORY EFFECTS OF (-)-EPIGALLOCATECHIN GALLATE AND LYCOPENE ON SPONTANEOUS HEPATOTUMORIGENESIS IN C3H/HeN MICE

NO INHIBITORY EFFECTS OF (-)-EPIGALLOCATECHIN GALLATE AND LYCOPENE ON SPONTANEOUS HEPATOTUMORIGENESIS IN C3H/HeN MICE

Prevention of N‐Methylnitrosourea‐induced Colon Carcinogenesis in F344 Rats by Lycopene and Tomato Juice Rich in Lycopene

Lycopene inhibition of cell cycle progression in breast and endometrial cancer cells is associated with reduction in cyclin D levels and retention of p27Kip1 in the cyclin E–cdk2 complexes

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