Chemoprevention of 7,12-dimethylbenz[a]anthracene (DMBA)-induced oral carcinogenesis in hamster cheek pouch by topical application of resveratrol complexed with 2-hydroxypropyl-β-cyclodextrin

Berta, Giovanni Nicolao; Salamone, Paolina; Sprio, Andrea Elio; Scipio, Federica Di; Marinos, Lucy Marcela; Sapino, Simona; Carlotti, Maria Eugenia; Cavalli, Roberta; Carlo, Francesco Di

doi:10.1016/j.oraloncology.2009.10.007

Cited by 39 publications

(39 citation statements)

References 37 publications

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“…Untreated H9c2 were used as control. H9c2 viability was assessed after the injury by 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyl-tetrazolium bromide (MTT) [19]. Briefly, MTT was added to growth medium (final concentration 0.5 mg/ml) and cells were further cultured for 3 h in normal condition.…”

Section: 1mentioning

confidence: 99%

Injured cardiomyocytes promote dental pulp mesenchymal stem cell homing

Scipio

Sprio

Folino

et al. 2014

Biochimica et Biophysica Acta (BBA) - General Subjects

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Section: 1mentioning

confidence: 99%

Injured cardiomyocytes promote dental pulp mesenchymal stem cell homing

Scipio

Sprio

Folino

et al. 2014

Biochimica et Biophysica Acta (BBA) - General Subjects

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“…Rahal et al [33] have shown that RSV in a rat model of Crohn's disease reduces the level of inflammatory cytokines (TNF-α, TNF-β1 oraz IL-1βi IL-6) and decreases the level of tissue fibrosis. In a model of acute pancreatitis induced by taurocholate, RSV reduced histopathological changes and lowered the level of biochemical markers in blood serum (renin activity, angiotensin II level, endothelin and NO) [5].…”

Section: The Biological Activity Of Resveratrolmentioning

confidence: 97%

Resveratrol and Its Analogues – Is It a New Strategy of Anticancer Therapy?

Borys

Khozmi

Kranc

et al. 2017

Advances in Cell Biology

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Summary: Resveratrol (RSV) is one of the polyphenols -metabolites common in plants,however it does not occur in animals. It occurs mainly in grape skin (Vitisvinifera), peanuts (Arachis hypogeal) and in the roots of (Polygonumcupidatum) a traditional Chinese curative plant. RSV has a preventive property against the most serious diseases of modern world such as cancer, neurodegenerative diseases and cardiovascular diseases. Due to pleiotropy, RSV is currently the main object of many research teams' interest, which is shown by the significant number of publications devoted to this subject. Animal and human conducted studies have shown very low bioavailability of RSV (approx. 2%), which is the result of rapid biotransformation to sulphate and to a lesser extent, to the glucuronide conjugates as well. The studies on the improvement of RSV bioavailability, which have beencarried out for many years, have contributed to the synthesis of the analogues of more chemopreventive and more desirable pharmacokinetic properties. In order to enhance antiproliferative activity and RSV bioavailability, series of methyl analogues were synthesized and this will be described later in more detail. An example of such a derivative is 4,

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“…RSV application prevented the incidence and growth of oral preneoplastic lesions and oral squamous cell carcinoma in DMBA-induced oral carcinogenesis in the hamster cheek pouch [117]. RSV treatment reduced tumor growth of human nasopharyngeal carcinoma cells (CNE-2Z cell line) [118], head and neck cancer-derived tumor-initiating cells (HNC-TICs) [119], and head and neck squamous cell carcinoma (HNSCC) cells (FaDu cell line) [120], in nude mouse xenograft models.…”

Section: Other Cancers In Recent Years (2009-2014)mentioning

confidence: 99%

The pharmacology of resveratrol in animals and humans

Park

Pezzuto

2015

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Diseas

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In addition to thousands of research papers related to resveratrol (RSV), approximately 300 review articles have been published. Earlier research tended to focus on pharmacological activities of RSV related to cardiovascular systems, inflammation, and carcinogenesis/cancer development. More recently, the horizon has been broadened by exploring the potential effect of RSV on the aging process, diabetes, neurological dysfunction, etc. Herein, we primarily focus on the in vivo pharmacological effects of RSV reported over the past 5 years (2009-2014). In addition, recent clinical intervention studies performed with resveratrol are summarized. Some discrepancies exist between in vivo studies with animals and clinical studies, or between clinical studies, which are likely due to disparate doses of RSV, experimental settings, and subject variation. Nevertheless, many positive indications have been reported with mammals, so it is reasonable to advocate for the conduct of more definitive clinical studies. Since the safety profile is pristine, an added advantage is the use of RSV as a dietary supplement. This article is part of a Special Issue entitled: Resveratrol: Challenges in translating pre-clinical findings to improved patient outcomes.

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Chemoprevention of 7,12-dimethylbenz[a]anthracene (DMBA)-induced oral carcinogenesis in hamster cheek pouch by topical application of resveratrol complexed with 2-hydroxypropyl-β-cyclodextrin

Cited by 39 publications

References 37 publications

Injured cardiomyocytes promote dental pulp mesenchymal stem cell homing

Injured cardiomyocytes promote dental pulp mesenchymal stem cell homing

Resveratrol and Its Analogues – Is It a New Strategy of Anticancer Therapy?

The pharmacology of resveratrol in animals and humans

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