2007
DOI: 10.1016/j.ejca.2006.09.022
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Chemoprevention of aberrant crypt foci in the colon of rats by dietary onion

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Cited by 24 publications
(12 citation statements)
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“…Preclinical studies found garlic to be protective when administered during the initiation phase of aberrant crypt foci (preneosplastic lesions for colon cancer) induction , but only diallyl disulfide was effective in postinitiation phase studies . Also, onion significantly inhibited chemically induced aberrant crypt foci formation in preclinical studies, both when onion was given during the initiation phase and when it was given during the postinitiation phase of carcinogenesis .…”
Section: Discussionmentioning
confidence: 99%
“…Preclinical studies found garlic to be protective when administered during the initiation phase of aberrant crypt foci (preneosplastic lesions for colon cancer) induction , but only diallyl disulfide was effective in postinitiation phase studies . Also, onion significantly inhibited chemically induced aberrant crypt foci formation in preclinical studies, both when onion was given during the initiation phase and when it was given during the postinitiation phase of carcinogenesis .…”
Section: Discussionmentioning
confidence: 99%
“…SAC and DADS in the diet decreased MNU-induced O6-methylguanine adducts bound to mammary cell DNA in rats (59). Dried onion at 5% in the rat diet reduced the number and size of aberrant crypt foci induced by azoxymethane or MNU (60). Aqueous garlic extracts reduced the mutagenicity of ionizing radiation, peroxides, Adriamycin, and N-methyl-N′-nitrosoguanidine (61).…”
Section: Possible Mechanismsmentioning
confidence: 99%
“…Sur le plan nutritionnel, l'oignon est considéré comme un aliment énergétique, protecteur et de soutien, car il contient des vitamines (vitamines B, vitamine C, provitamine A), des minéraux (potassium, sodium, zinc, fer, phosphore, sélénium, magnésium, manganèse, calcium…), des lipides, des protéines, des glucides, des huiles essentielles, des acides organiques, des fibres (Ciqual, 2013). Sur le plan theurapeutique, diverses études ont montré que la consommation régulière d'oignon cru jouerait un rôle dans la coagulation du sang, la prévention de diverses pathologies (athérosclérose, cataracte), de certaines maladies cardio-vasculaires et cancers (Mégroz et Baumgartner, 2000;Bianchini et Vainio, 2001;You et Li, 2005;Graf et al, 2005, Tache et al, 2007. La production annuelle mondiale a été estimée à plus de 75 000 000 tonnes en 2009 (CNUCED, 2013).…”
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