Chemoprevention of bladder cancer

Rochelle, Jeffrey La; Kamat, Ashish M.; Grossman, H. Barton

doi:10.1111/j.1464-410x.2008.07970.x

Cited by 5 publications

(4 citation statements)

References 37 publications

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“…If these foods or compounds do indeed prove to demonstrate clear and potent bioactivity, they can be utilized to improve upon the bladder cancer burden in several ways. One strategy would be “primary” chemoprevention by targeting high‐risk populations, such as heavy smokers and those with environmental/occupational exposures . Another strategy is a “tertiary” chemopreventive approach, in patients who have a successful complete cystoscopic resection of their superficial bladder cancer.…”

Section: Concluding Thoughtsmentioning

confidence: 99%

“…One strategy would be "primary" chemoprevention by targeting high-risk populations, such as heavy smokers and those with environmental/occupational exposures. [181] Another strategy is a "tertiary" chemopreventive approach, in patients who have a successful complete cystoscopic resection of their superficial bladder cancer. In this case, the goal is to reduce or eliminate the wellknown high risk of recurrent tumors and the progression to invasive disease.…”

Section: Concluding Thoughtsmentioning

confidence: 99%

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Cruciferous Vegetables, Isothiocyanates, and Bladder Cancer Prevention

Abbaoui

Lucas

Riedl

et al. 2018

Molecular Nutrition Food Res

132

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Bladder cancer is a significant health burden due to its high prevalence, risk of mortality, morbidity, and high cost of medical care. Epidemiologic evidence suggests that diets rich in cruciferous vegetables, particularly broccoli, are associated with lower bladder cancer risk. Phytochemicals in cruciferous vegetables, such as glucosinolates, which are enzymatically hydrolyzed to bioactive isothiocyanates, are possible mediators of an anticancer effect. In vitro studies have shown inhibition of bladder cancer cell lines, cell cycle arrest, and induction of apoptosis by these isothiocyanates, in particular sulforaphane and erucin. Although not yet completely understood, many mechanisms of anticancer activity at the steps of cancer initiation, promotion, and progression have been attributed to these isothiocyanates. They target multiple pathways including the adaptive stress response, phase I/II enzyme modulation, pro-growth, pro-survival, pro-inflammatory signaling, angiogenesis, and even epigenetic modulation. Multiple in vivo studies have shown the bioavailability of isothiocyanates and their antitumoral effects. Although human studies are limited, they support oral bioavailability with reasonable plasma and urine concentrations achieved. Overall, both cell and animal studies support a potential role for isothiocyanates in bladder cancer prevention and treatment. Future studies are necessary to examine clinically relevant outcomes and define guidelines on ameliorating the bladder cancer burden.

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Section: Concluding Thoughtsmentioning

confidence: 99%

Section: Concluding Thoughtsmentioning

confidence: 99%

Cruciferous Vegetables, Isothiocyanates, and Bladder Cancer Prevention

Abbaoui

Lucas

Riedl

et al. 2018

Molecular Nutrition Food Res

132

View full text Add to dashboard Cite

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“…The association between the use of different types of analgesics and BC risk is controversial. On the one hand, there was strong experimental and epidemiological evidence that nonsteroidal anti-inflammatory drugs (NSAIDs) and cyclooxygenase 2 (COX-2) inhibitors might have a potential as cancer chemopreventive agents [ 29 ]. For example, ibuprofen, naproxen, indomethacin, piroxicam, and celecoxib inhibit BC development in a variety of human and animal models [ 29 , 30 ].…”

Section: Discussionmentioning

confidence: 99%

“…On the one hand, there was strong experimental and epidemiological evidence that nonsteroidal anti-inflammatory drugs (NSAIDs) and cyclooxygenase 2 (COX-2) inhibitors might have a potential as cancer chemopreventive agents [ 29 ]. For example, ibuprofen, naproxen, indomethacin, piroxicam, and celecoxib inhibit BC development in a variety of human and animal models [ 29 , 30 ]. However, other studies describe an increased risk of BC associated with the use of phenacetin-containing analgesics, particularly with longer use.…”

Section: Discussionmentioning

confidence: 99%

Risk Factors Involved in the High Incidence of Bladder Cancer in an Industrialized Area in North-Eastern Spain: A Case–Control Study

Caballero

Gili

Pereira

et al. 2023

JCM

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Bladder cancer (BC) is the most common of the malignancies affecting the urinary tract. Smoking and exposure to occupational and environmental carcinogens are responsible for most cases. Vallès Occidental is a highly industrialized area in north-eastern Spain with one of the highest incidences of BC in men. We carried out a case–control study in order to identify the specific risk factors involved in this area. Three hundred and six participants were included (153 cases BC and 153 controls matched for age and sex): in each group, 89.5% (n = 137) were male and the mean age was 71 years (range 30–91; SD = 10.6). There were no differences between groups in family history, body mass index, or dietary habits. Independent risk factors for CV were smoking (OR 2.08; 95% CI 1.30–3.32; p = 0.002), the use of analgesics in nonsmokers (OR 10.00; 95% CI 1.28–78.12; p = 0.028), and profession (OR: 8.63; 95% CI 1.04–71.94; p = 0.046).The consumption of black and blond tobacco, the use of analgesics in nonsmokers, and occupational exposures are risk factors for the development of BC in this area, despite the reduction in smoking in the population and the extensive measures taken in the last few decades in major industries to prevent exposure to occupational carcinogens.

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