Chemoprevention of polyp recurrence with curcumin followed by silibinin in a case of multiple colorectal adenomas

Alfonso-Moreno, Vicente; López-Serrano, Antonio; Moreno-Osset, E

doi:10.17235/reed.2017.5178/2017

Cited by 7 publications

(4 citation statements)

References 5 publications

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“…The role of CUR was investigated in the prevention of cancer and treatment of pre-invasive tumors, reporting some preliminary results [55,56,57]. Oral and topic formulations were proposed, tailoring high-risk patients with CUR-based pharmacological interventions and tracking the reduction of pre-invasive lesions when exposed to CUR and related compounds.…”

Section: Clinical Data Of Curcumin As a Therapeutical Anti-cancer mentioning

confidence: 99%

Curcumin: New Insights into an Ancient Ingredient against Cancer

Willenbacher

Khan²,

Mujica³

et al. 2019

IJMS

129

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Cancer patients frequently use complementary medicine. Curcumin (CUR) and its derivates (from the extract of Curcuma longa L.) represent some of the most frequently used ones, having a long history in traditional Asian medicine. CUR was demonstrated, both in vitro and in vivo, to have significant anti-inflammatory effects, thus potentially counteracting cancer-promoting inflammation, which is a hallmark of cancer. CUR modulate a plethora of signaling pathways in cancer cells, comprising the NF-κB (nuclear factor k-light-chain-enhancer of activated B cells), the JAK/STAT (Janus-Kinase/Signal Transducers and Activators of Transcription), and the TGF-β (transforming growth factor-β) pathways. Furthermore, CUR confers properties of electron receptors, which destabilize radical oxygen species (ROS), explaining its antioxidant and anti-apopototic effects. Although CUR has a low bioavailability, its role in advanced cancer treatment and supportive care was addressed in numerous clinical trials. After promising results in phase I–II trials, multiple phase III trials in different indications are currently under way to test for direct anti-cancer effects. In addition, CUR exerts beneficial effects on cancer treatment-related neurotoxcity, cardiotoxicity, nephrotoxicity, hemato-toxicity, and others. More efficient galenic formulations are tested to optimze CUR’s usability in cancer treatment. This review should provide a comprehensive overview of basic science, and pre-clinical and clinical data on CUR in the field of oncology.

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Section: Clinical Data Of Curcumin As a Therapeutical Anti-cancer mentioning

confidence: 99%

Curcumin: New Insights into an Ancient Ingredient against Cancer

Willenbacher

Khan²,

Mujica³

et al. 2019

IJMS

129

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“…Surprisingly, a difference in polyp size and number between placebo and curcumin was not found. Furthermore, a case report [66] of a patient with 54 polyps at index colonoscopy, with all genetic tests negative for genetic polyposis demonstrated an interesting result. Indeed, after the removal of about 40 polyps, the patient was given curcumin 400 mg/day for three months.…”

Section: Human Clinical Studiesmentioning

confidence: 96%

Curcumin and Colorectal Cancer: From Basic to Clinical Evidences

Pricci

Girardi

Giorgio

et al. 2020

IJMS

161

100

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Curcumin diffuses through cell membranes into the endoplasmic reticulum, mitochondria, and nucleus, where it exerts actions, as an antioxidant property. Therefore, its use has been advocated for chemopreventive, antimetastatic, and anti-angiogenic purposes. We conducted a literature review to summarize studies investigating the relationship between curcumin and colorectal cancer (CRC). In vitro studies, performed on human colon cancer cell lines, showed that curcumin inhibited cellular growth through cycle arrest at the G2/M and G1 phases, as well as stimulated apoptosis by interacting with multiple molecular targets. In vivo studies have been performed in inflammatory and genetic CRC animal models with a chemopreventive effect. To improve curcumin bioavailability, it has been associated with small particles that increase its absorption when orally administered with excellent results on both inflammation and carcinogenesis. Curcumin has been used, moreover, as a component of dietetic formulations for CRC chemoprevention. These combinations showed in vitro and in vivo anticarcinogenetic properties in inflammation-related and genetic CRC. A synergic effect was suggested using an individual constituent dosage, which was lower than that experimentally used “in vivo” for single components. In conclusion, curcumin falls within the category of plant origin substances able to prevent CRC in animals. This property offers promising expectations in humans.

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“…Astonishingly, no variation in polyp numbers along with sizes amongst placebo as well as curcumin was observed. Moreover, a case report [38], in a patient with 54 polyps at index colonoscopy with all the genetic investigation negative regarding genetic polyposis illustrated intriguingly that subsequent to approximately 40 polyps surgical elimination, administration of 400mg curcuminfor3mths followed by silibinin. Following 2yrs just3 polyps were picked up at the follow up colonoscopy.…”

Section: Furthermore Assessment Of Curcumin Has Been Performed In Hea...mentioning

confidence: 99%

An Update on Role of Curcumin in Colorectal Cancer-A Minireview

Kaur¹,

Gautam²,

Allahbadia³

2022

Act Scie Nutr

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Earlier we had reviewed the part of curcumin as an anti-oxidant, anti-inflammatory, neuro shielding, anticancer, hapatoprotecting, as well as cardio shielding actions. Further its bioavailability issues, bio effectiveness as well as safety parameters along with quality properties of Curcumin were further tackled, besides its role in PCOS. Here we tried to concentrate on the part of curcumin in Colorectal cancer (CRC). Diffusion of curcumin takes place via the cell membrane into the cell membrane endoplasmic reticulum (ER), mitochondria along with nucleus where its anti-oxidant characteristics get impacted. Hence its utilization has been recommended regarding chemopreventive, antimetastatic along with anti-angiogenic uses. Thus we conducted a minireview review on role on CRC with the utilization of search engines like PubMed, google scholar, web of science, Cochrane library from 1995 till date in 2022 with the utilization of MeSH terms like Curcumin; antioxidant actions; other anti-inflammatory actions; anti angiogenic actions; CRC; chemopreventive actions; ER stress; familial adenomatous polyposis (FAP); in vivo studies in animal models; in vitro studies. We found 2500 articles but selected only 53 articles for this review with the journals constraints of upto 50 references. No meta-analysis was done. In vitro studies conducted on human colon cancer cell lines illustrated that Curcumin hampered growth via cell cycle arrest at the G2/M along with G1 phase, besides crosstalk with numerous molecular targets. In vivo studies were conducted in mice having inflammatory along with genetic CRC in animal models possessing a chemopreventive action. regarding enhancement of bioavailability, it has been correlated with small particles that escalate its absorption on oral delivery with great outcomes in both inflammation as well as carcinogenesis. Furthermore curcumin utilization has been done in dietary formulation for CRC chemoprevention. These illustrated that in vivo along with in vitro anti carcinogenic characteristics in inflammatory along with genetic CRC.A synergestic action was pointed on utilization of unique dosages of the component that was lesser in contrast to experimentally utilized for single component. Thus with favourable actions in animal models, good scope of their working in humans preclinical studies.

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Chemoprevention of polyp recurrence with curcumin followed by silibinin in a case of multiple colorectal adenomas

Cited by 7 publications

References 5 publications

Curcumin: New Insights into an Ancient Ingredient against Cancer

Curcumin: New Insights into an Ancient Ingredient against Cancer

Curcumin and Colorectal Cancer: From Basic to Clinical Evidences

An Update on Role of Curcumin in Colorectal Cancer-A Minireview

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