Chemoprevention with a tea from hawthorn (Crataegus oxyacantha) leaves and flowers attenuates colitis in rats by reducing inflammation and oxidative stress

Nascimento, Roberto de Paula do; Machado, Ana Paula da Fonseca; Lima, Verena Silva; Moya, Amanda Maria Tomazini Munhoz; Reguengo, Lívia Mateus; Bogusz, Stanislau; Leal, Raquel Franco; Cao-Ngoc, Phu; Rossi, Jean Christophe; Leclercq, Laurent; Cottet, Hervé; Cazarin, Cínthia Baú Betim; Maróstica, Mário Roberto

doi:10.1016/j.fochx.2021.100139

Cited by 11 publications

(6 citation statements)

References 77 publications

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“…The cell lysate was diluted twice with PBS and then stored at 4 °C. Based on previous reports ( Nascimento et al., 2021 ), CAT activity and MDA levels were evaluated. All of the tests were carried out according to the manufacturer's standard protocols.…”

Section: Methodsmentioning

confidence: 99%

Elafibranor emerged as a potential chemotherapeutic drug for non-muscle invasive bladder cancer

Wang,

Shan,

Wang

et al. 2024

Cell Insight

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Section: Methodsmentioning

confidence: 99%

Elafibranor emerged as a potential chemotherapeutic drug for non-muscle invasive bladder cancer

Wang,

Shan,

Wang

et al. 2024

Cell Insight

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“…The total saponins content of PNL and FPNL were assayed by the vanillin and glacial acetic acid method ( 19 ). 1.5 mg ginsenoside Re standard was weighed and added to a 6 ml methanol solution to dissolve entirely.…”

Section: Methodsmentioning

confidence: 99%

Antifatigue Effect of Panax Notoginseng Leaves Fermented With Microorganisms: In-vitro and In-vivo Evaluation

et al. 2022

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Fatigue is a common physiological phenomenon caused by many complicated factors. Excessive fatigue will lead to a series of uncomfortable reactions and damage body health. Panax notoginseng leaves (PNL) is a new resource food that good for soothing nerves, nourishing the heart, and strengthening the spleen. Microbial fermentation could increase the content of bio-ingredients and produce new active ingredients. However, the effect of fermented P. notoginseng leaves (FPNL) on antifatigue and the molecular mechanisms remain to be elucidated. Thus, in this study, we evaluated the antifatigue effect of co-fermented P. notoginseng leaves by Saccharomyces cerevisiae and Bacillus subtilis in-vitro and in-vivo, and its mechanism was further elucidated. The results showed that FPNL exhibited higher saponins, organic phenolic acids content, and antioxidant activity than PNL. FPNL improved ISO-induced H9c2 myocardial cell damage by alleviating apoptosis (modulating Bax and Bcl-2 protein expression) and reducing antioxidant activity in-vitro. Moreover, in-vivo experiment showed that FPNL significantly prolonged the weight-loading swimming time of mice. After gavaged FPNL, the levels of liver glycogen (LG) and serum lactate dehydrogenase (LDH) activity were increased in mice. In contrast, the levels of blood urea nitrogen (BUN), lactate acid, and malondialdehyde (MDA) were decreased. In summary, our results indicated that FPNL showed a good antifatigue effect in-vivo and in-vitro.

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“…Meanwhile, it could also significantly lower plasma levels of TNF‐α and monocyte chemoattractant protein 1 (MCP‐1) and downregulate the hepatic expression of MCP‐1 and IL‐1β in type 2 diabetes (T2D) rats (He et al., 2021). Moreover, the hawthorn pulp could reduce plasma myeloperoxidase, C‐reactive protein, and alkaline phosphatase (ALP) levels, suggesting its potential to block or regulate intestinal inflammation in a castor oil–induced rat model (Nascimento et al., 2021; Sammari et al., 2021). In addition, a series of animal experiments have demonstrated that hawthorn pulp can alleviate chronic diseases associated with inflammation, such as osteoarthritis, ulcerative colitis, atherosclerosis (AS), chronic heart failure, hepatic fibrosis, and obesity, but the specific mechanism of action has not yet been completely revealed (Alsharif et al., 2022; Cheng et al., 2020; Hamza et al., 2020; He et al., 2021; Nguyen et al., 2021).…”

Section: Bioactivities Based On In Vitro and In Vivo Studiesmentioning

confidence: 99%

The hawthorn (Crataegus pinnatifida Bge.) fruit as a new dietary source of bioactive ingredients with multiple beneficial functions

Ma,

Yang,

et al. 2024

Food Frontiers

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The discovery of new natural sources has brought increased attention to the development of functional foods. The hawthorn (Crataegus pinnatifida Bge.) fruit is an underutilized fruit due to its benefits for human health and good taste. It contains a variety of bioactive ingredients, contributing to its multiple beneficial functions and applications. This review summarized and discussed the main bioactive ingredients, beneficial functions based on in vitro, in vivo, and human studies, and different applications of the hawthorn fruit according to the updated literature in the past 3 years. Hawthorn berries contain phenolic acids, flavonoids, proanthocyanidins, pectin, and many other bioactive components, which have a variety of beneficial functions, such as antioxidant, anti‐inflammatory, antibacterial, antidiabetic, intestinal protection, cardiovascular protection, hepatoprotection, anti‐cancer, and neuroprotection. Its potential molecular mechanism and different food‐related applications such as hawthorn wine and antioxidant drink are discussed in detail in this review. Additionally, hawthorn berries are shown to be safe when consumed within the proper dosage. Collectively, this updated review indicates that the hawthorn fruit can be a new dietary source of bioactive ingredients with multiple beneficial functions and can be affordably developed into functional and medicinal foods for the prevention and management of certain chronic diseases.

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Chemoprevention with a tea from hawthorn (Crataegus oxyacantha) leaves and flowers attenuates colitis in rats by reducing inflammation and oxidative stress

Abstract: Graphical abstract

Cited by 11 publications

References 77 publications

Elafibranor emerged as a potential chemotherapeutic drug for non-muscle invasive bladder cancer

Elafibranor emerged as a potential chemotherapeutic drug for non-muscle invasive bladder cancer

Antifatigue Effect of Panax Notoginseng Leaves Fermented With Microorganisms: In-vitro and In-vivo Evaluation

The hawthorn (Crataegus pinnatifida Bge.) fruit as a new dietary source of bioactive ingredients with multiple beneficial functions

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