Chemopreventive Activity of Sesquiterpene Lactones (SLs) from Yacon against TPA-induced Raji Cells Deformation

Siriwan, Dalad; Miyawaki, Chie; Miyamoto, Tamie; Naruse, Takayuki; Okazaki, Kanzo; Tamura, Hirotoshi

doi:10.3923/pjbs.2011.605.609

Cited by 10 publications

(6 citation statements)

References 10 publications

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“…In the positive control, Raji cells were deformed at 28 cells from 500 cells after treatment with cancer-promoting compounds, TPA and sodium butyrate (Figure 3). These results concurred with a previous report [27]. Compared to the positive control, A. comosus 'Pattavia', A. comosus 'Phulae', D. zibethinus 'Chanee' and D. zibethinus 'Monthong' exhibited the same quantity of deformed cells as a positive control, suggesting that these four extracts lacked chemopreventive properties determined by this assay.…”

Section: Chemopreventive Properties Of Fruit Extractssupporting

confidence: 92%

“…Screening of chemopreventive properties was determined using a phenotypic screening assay. Concentrations of 1 × 10 5 log phase cells were cultured per well of a 6-well plate in RMPI 1640 containing 10% (v/v) fetal calf serum, pyruvate (1 mM), penicillin (100 U/mL), streptomycin (100 µg/mL), 10 mM sodium butyrate and 65 nM 12-O-tetradecanoyl-phorbol-13-acetate (TPA or PMA, Merck, Darmstadt, Germany) with or without the fruit extract as described [27]. Cells were then incubated for the next 48 h at 37 • C. Deformed Raji cells (tree branch-like, dilation and flatness) were scored under a phase contrast microscope with a DP74 camera (IX83, Olympus, Tokyo, Japan).…”

Section: Determination Of Chemopreventive Properties Using Phenotypic Screening Assay or Anti-deforming Assaymentioning

confidence: 99%

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Analysis of Phytonutrients, Anti-Mutagenic and Chemopreventive Effects of Tropical Fruit Extracts

Temviriyanukul

Kittibunchakul

Trisonthi

et al. 2021

Foods

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Thailand is located in the tropics and a wide variety of fruits are grown commercially. However, studies regarding the phytonutrients, anti-mutagenic and chemopreventive effects of these fruits are limited. Thus, phytochemical profiles and inhibition of key enzymes involved in obesity and diabetes, together with anti-mutagenic and chemopreventive properties of eight tropical fruit extracts cultivated in Thailand, including Psidium guajava ‘Kimju’, Psidium guajava ‘Keenok’, Ananas comosus ‘Pattavia’, Ananas comosus ‘Phulae’, Durio zibethinus ‘Chanee’, Durio zibethinus ‘Monthong’, Carica papaya ‘Khaekdum’ and Mangifera indica ‘Namdokmai’ were investigated. Different cultivars were also compared. Results showed that M. indica ‘Namdokmai’ was the most antioxidant-rich extract containing abundant 4-hydroxybenzoic acid and its derivative, gallic acid, as the main phenolics. M. indica ‘Namdokmai’ also exhibited high inhibitory capacities (>60% inhibition under studied conditions) against lipase, α-amylase and α-glucosidase, key enzymes as drug targets for controlling obesity and type 2 diabetes. Interestingly, all fruit extracts suppressed food mutagen-induced DNA mutations assayed by the Ames test, especially M. indica ‘Namdokmai’ and C. papaya ‘Khaekdum’ (>50% inhibition at 200 µg/plate). The M. indica ‘Namdokmai’ was also the most potent extract for suppression of cancer promotion (>90% inhibition at 200 µg/mL) followed by P. guajava ‘Kimju’, P. guajava ‘Keenok’ and C. papaya ‘Khaekdum’. Results potentially indicated that fruit intake after overcooked meat consumption might supplement nutrients and fiber and also reduce DNA mutation sources.

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Section: Chemopreventive Properties Of Fruit Extractssupporting

confidence: 92%

Section: Determination Of Chemopreventive Properties Using Phenotypic Screening Assay or Anti-deforming Assaymentioning

confidence: 99%

Analysis of Phytonutrients, Anti-Mutagenic and Chemopreventive Effects of Tropical Fruit Extracts

Temviriyanukul

Kittibunchakul

Trisonthi

et al. 2021

Foods

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“…Different biological activities of some of the SLs isolated from S. sonchifolius have been previously reported, that include antibacterial, antifungal, cytotoxic, anti-inflammatory, hypoglycemic, and the inhibition of nitric oxide production (Choi et al, 2010;Genta et al, 2010;Schorr et al, 2007;Siriwan et al, 2011a). As part of previous work with SLs isolated from S. sonchifolius, the antitrypanosomal activity of enhydrin (1), uvedalin (2) and polymatin B (3) on Trypanosoma cruzi was reported (Frank et al, 2013).…”

Section: Resultsmentioning

confidence: 99%

The sesquiterpene lactone polymatin B from Smallanthus sonchifolius induces different cell death mechanisms in three cancer cell lines

et al. 2015

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“…Yacon leaves are pest-resistant and antimicrobial, and these properties are associated with the content of monoterpenes, sesquiterpenes, and diterpenes [25,71]. In in vitro studies, sesquiterpene lactones from yacon leaves have been shown to strongly inhibit cancer cell deformation and proliferation [13,72,73,74]. The extracts of dried leaves have shown antioxidant function related to their phenolic content.…”

Section: Health Effects (Usually Benefits) Of Yacon and Its Bioactmentioning

confidence: 99%

A Sustainable Wholesome Foodstuff; Health Effects and Potential Dietotherapy Applications of Yacon

Yan

Welch²,

Rush

et al. 2019

Nutrients

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A sustainable food supply is an ever-growing public and planetary health concern influenced by food culture, food practices, and dietary patterns. Globally, the consumption of plant foods that offer physiological and biochemical benefits is increasing. In recent years, products made from yacon (Smallanthus sonchifolius) tubers and leaves, e.g., in the form of syrup, powder, and herbal tea, have steadily emerged with scientific evidence to validate their possible health claims. Yacon was introduced to New Zealand in 1966, and its products can now be produced on a commercial scale. This paper reviews literature published mainly in the last 10 years concerning the health-related properties of yacon as a wholesome foodstuff and its bioactive components, e.g., fructooligosaccharides. Literature was sourced from Web of Science, PubMed, EBSCO Health, and Google Scholar up to June 2019. The potential markets for yacon in the field of food technology and new dietotherapy applications are discussed. Furthermore, the unique features of New Zealand-produced yacon syrup are introduced as a case study. The paper explores the scientific foundation in response to the growing public interest in why and how to use yacon.

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Chemopreventive Activity of Sesquiterpene Lactones (SLs) from Yacon against TPA-induced Raji Cells Deformation

Cited by 10 publications

References 10 publications

Analysis of Phytonutrients, Anti-Mutagenic and Chemopreventive Effects of Tropical Fruit Extracts

Analysis of Phytonutrients, Anti-Mutagenic and Chemopreventive Effects of Tropical Fruit Extracts

The sesquiterpene lactone polymatin B from Smallanthus sonchifolius induces different cell death mechanisms in three cancer cell lines

A Sustainable Wholesome Foodstuff; Health Effects and Potential Dietotherapy Applications of Yacon

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