2005
DOI: 10.1016/j.canlet.2004.09.041
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Chemopreventive and therapeutic effects of curcumin

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Cited by 781 publications
(457 citation statements)
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“…Compounds in garlic, pepper, rosemary, turmeric, and cinnamon appear to influence phase I and phase II enzymes (85,(88)(89)(90). Multiple compounds in garlic, such as diallyl sulfide (DAS), diallyl sulfone (DASO), and diallyl sulfoxide (DASO 2 ) may be involved in directly inhibiting CYP2E1 activity (85).…”
Section: Inflammation-sincementioning
confidence: 99%
See 1 more Smart Citation
“…Compounds in garlic, pepper, rosemary, turmeric, and cinnamon appear to influence phase I and phase II enzymes (85,(88)(89)(90). Multiple compounds in garlic, such as diallyl sulfide (DAS), diallyl sulfone (DASO), and diallyl sulfoxide (DASO 2 ) may be involved in directly inhibiting CYP2E1 activity (85).…”
Section: Inflammation-sincementioning
confidence: 99%
“…The cause of the strong induction of phase II enzymes remains largely unknown, however synergistic effects of a combination of phenolic compounds are thought to contribute to these findings (89). Another example of the widespread effects of herbs and spices comes from the observations that curcumin inhibited reactions catalyzed by CYP1A1, 1A2, and 2B1 in rat liver cells and induced phase II enzymes, especially GST and QR in the liver and kidney in rats, human melanoma cells, and glutathione S-transferase P1-1 (GSTP1-1) in K562 and Jurkat leukemia cells (88). Shen et al (91) recently demonstrated in vivo that curcumin (1000 mg/kg), along with transporter proteins and oxidative stress genes, could regulate phase I and II xenobiotic metabolizing enzyme genes in mouse liver and small intestine through Nrf2-dependent pathways.…”
Section: Inflammation-sincementioning
confidence: 99%
“…Curcumin (Cum), the principal polyphenolic curcuminoid, obtained from the turmeric rhizome Curcuma longa, has been reported for its potential chemopreventive and chemotherapeutic activity by influencing different stages of carcinogenesis, including cell cycle arrest, differentiation, and apoptosis in a series of cancers (Pan et al, 2000;Surh et al, 2001;Aggarwal et al, 2003;Duvoix et al, 2005;Aggarwal et al, 2009;EI-Azab et al, 2011). For example, In vitro and in vivo experiments show the ability of Cum in inhibiting skin squamous cell carcinoma growth and blocking tumor progression (Phillips et al, 2011).…”
Section: Introductionmentioning
confidence: 99%
“…Curcumin is a powerful antioxidant and inhibits the expression of the enzyme cyclooxygenase 2 (Cox 2) at least in part via interference with activation of the transcription factor NFkB [2,14]. In vitro, curcumin inhibits the growth of cancer cells with an IC 50 value of 20-75μM [6,16].…”
Section: Introductionmentioning
confidence: 99%