“…Curcumin (Cum), the principal polyphenolic curcuminoid, obtained from the turmeric rhizome Curcuma longa, has been reported for its potential chemopreventive and chemotherapeutic activity by influencing different stages of carcinogenesis, including cell cycle arrest, differentiation, and apoptosis in a series of cancers (Pan et al, 2000;Surh et al, 2001;Aggarwal et al, 2003;Duvoix et al, 2005;Aggarwal et al, 2009;EI-Azab et al, 2011). For example, In vitro and in vivo experiments show the ability of Cum in inhibiting skin squamous cell carcinoma growth and blocking tumor progression (Phillips et al, 2011).…”