Chemopreventive and therapeutic potential of chrysin in cancer: mechanistic perspectives

Chrysin Inhibits Lymphangiogenesis <i>in Vitro</i>

“…9,11,12) In addition, chrysin inhibits angiogenesis by suppression of endothelial cell proliferation and migration in human umbilical vascular endothelial cells (HUVEC). [18][19][20][21] However, the potency of chrysin on lymphangiogenesis is not currently available.…”

“…In vitro and in vivo models have shown that chrysin inhibits cancer growth and metastasis by induction of apoptosis, alteration of cell cycle and inhibition of angiogenesis and invasion through the modulation of multiple cell signaling pathways. 9) However, the information between chrysin, lymphatic endothelial cells and lymphangiogenesis is not currently available.…”

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“…Defects in cell cycle regulation are major causes of the abnormal proliferation of cancer cells, among which the deregulation of the G1/S transition is especially common in human cancers [69,70]. α-MG has been shown to modulate the major cell cycle mediators at micromolar concentrations, causing a blockage of the G1/S transition, resulting in a G1-phase cell cycle arrest in many cancers, such as prostate cancer [71], melanoma [72], breast cancer [73], and pancreatic cancer [74].…”

“…More than 70 % of all cancer deaths have occurred in low-and middle-income countries. The global burden of cancer will continue to increase because of aging and growing urbanization as well as accumulated adoption of a cancer-associated lifestyle like smoking, sedentary habits, and westernized diets [2]. It is estimated that there would be about 22 million new cancer cases and more than 13 million deaths worldwide by 2030 according to the WHO report [3].…”

Comparison of the effects of resistance modifiers on prostate cancer, mouse lymphoma and colon cancer cells

“…The emergence of new anticancer drugs could not only improve the efficacy of treatment, but also alleviate the side-effects through a more detailed understanding of the mechanism of action [5]. Furthermore, the use of chemopreventive agents could be a promising means of inhibiting carcinogenesis [6,7,8].…”