Chemopreventive effect of 4'‑hydroxychalcone on intestinal tumorigenesis in Apc<i><sup>Min</sup></i> mice

Chen, Qing; Lei, Jiahong; Zhou, Jinzhe; Ma, Shaoze; Huang, Qi; Ge, Bujun

doi:10.3892/ol.2021.12474

Cited by 9 publications

(2 citation statements)

References 48 publications

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“…It plays an important role in the processes of tumor cell proliferation, differentiation, adhesion, invasion, and metastasis [35,36]. APC Min/+ mice are an ideal mouse model for studying the mechanism of CRC [37]. Previously, studies have found that lncRNA can participate in the occurrence and development of tumors through various molecular mechanisms and can serve as targets for cancer diagnosis, treatment, and prognosis prediction [38].…”

Section: Discussionmentioning

confidence: 99%

Long noncoding RNA THOR, a novel target biomolecule, is involved in the progression of colorectal cancer

Zhou

Ouyang

et al. 2023

Preprint

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THOR is a long noncoding RNA that is highly conserved and highly expressed in a variety of human tumor cells. A large number of studies show that THOR is deeply involved in the occurrence and development of a variety of cancers. However, the role and potential molecular mechanisms of THOR in the initiation and progression of CRC have not been fully elucidated. Here, we demonstrate that THOR is crucial for the occurrence of CRC; it interacts with IGF2BP1 to regulate the downstream Wnt/β-catenin signaling pathway. To clarify the contribution of THOR in the occurrence and development of CRC, we established THOR-deficient APCMin/+ mice and human colorectal cancer cells (SW480) using CRISPR/Cas9 technology. The results showed that the body weight and survival rate of THOR-deficient APCMin/+ mice increased; hyperlipidemia in elderly mice was alleviated, and changes in intestinal structure were attenuated. THOR knockout inhibited the growth, proliferation, and migration of SW480 cells. Downstream regulator genes, including c-MYC, APC, SOX9, Wnt1, CDH1, Axin1, Axin2, LEF 1, were knocked down with THOR knockout. In summary, our results indicate that THOR knockout inhibits the growth and migration of CRC cells and that THOR is a promising prognostic indicator for CRC patients. Moreover, the THOR-IGF2BP1-Wnt/β-catenin axis may be a potential therapeutic target for CRC, providing new insights into the important role of lncRNAs in cancer.

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Section: Discussionmentioning

confidence: 99%

Long noncoding RNA THOR, a novel target biomolecule, is involved in the progression of colorectal cancer

Zhou

Ouyang

et al. 2023

Preprint

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“…The predominant forms of naturally occurring chalcones are primarily hydroxylated, and hydroxylated chalcones exhibit more potent anticancer activity than chalcones with other functional groups [ 8 , 9 ]. Studies reported that hydroxychalcones elicited potent cytotoxicity against various cancers [ 10 , 11 , 12 ]. However, few studies focus on the anti-breast-cancer effect and the underlying mechanism of 2’-hydroxychalcone, which represents only one hydroxyl substituent on the 2’ position of the A ring and was found to show strong inhibition effects on lung cancer [ 13 ], cervical cancer [ 14 ], and colon cancer [ 15 ] cells.…”

Section: Introductionmentioning

confidence: 99%

2’-Hydroxychalcone Induces Autophagy and Apoptosis in Breast Cancer Cells via the Inhibition of the NF-κB Signaling Pathway: In Vitro and In Vivo Studies

Wang,

Liang,

Zhang

et al. 2024

Nutrients

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2’-Hydroxychalcone is a hydroxyl derivative of chalcones, which are biosynthetic precursors of flavonoids and rich in the human diet. The anticancer activity of 2’-hydroxychalcone has been reported in several cancers but remains to be investigated in breast cancer. In the current study, 2’-hydroxychalcone showed significant cytotoxicity against breast cancer cell lines MCF-7 and CMT-1211. It could inhibit breast cancer cell proliferation, migration, and invasion in vitro and suppress tumor growth and metastasis in vivo. Mechanistic investigation revealed that the NF-κB pathway was significantly inhibited by 2’-hydroxychalcone treatment accompanied by an excessive intracellular accumulation of reactive oxygen species, induction of endoplasmic reticulum stress, and activation of JNK/MAPK. In addition, 2’-hydroxychalcone elevated the autophagic levels in breast cancer cells equipped with increasing numbers of autophagy vesicles and complete autophagic flux. Finally, autophagy-dependent apoptosis was observed in 2’-hydroxychalcone-induced cell death. In conclusion, 2’-hydroxychalcone enhances the autophagic levels and induces apoptosis in breast cancer cells, which could be contributed to the inhibition of the pro-survival NF-κB signaling, indicating a promising potential for 2’-hydroxychalcone in future anticancer drug development.

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Chalcones: Promising therapeutic agents targeting key players and signaling pathways regulating the hallmarks of cancer

WalyEldeen

Sabet

El-Shorbagy

et al. 2023

Chemico-Biological Interactions

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Chemopreventive effect of 4'‑hydroxychalcone on intestinal tumorigenesis in Apc^Min mice

Cited by 9 publications

References 48 publications

Long noncoding RNA THOR, a novel target biomolecule, is involved in the progression of colorectal cancer

Long noncoding RNA THOR, a novel target biomolecule, is involved in the progression of colorectal cancer

2’-Hydroxychalcone Induces Autophagy and Apoptosis in Breast Cancer Cells via the Inhibition of the NF-κB Signaling Pathway: In Vitro and In Vivo Studies

Chalcones: Promising therapeutic agents targeting key players and signaling pathways regulating the hallmarks of cancer

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Chemopreventive effect of 4'‑hydroxychalcone on intestinal tumorigenesis in ApcMin mice

Cited by 9 publications

References 48 publications

Long noncoding RNA THOR, a novel target biomolecule, is involved in the progression of colorectal cancer

Long noncoding RNA THOR, a novel target biomolecule, is involved in the progression of colorectal cancer

2’-Hydroxychalcone Induces Autophagy and Apoptosis in Breast Cancer Cells via the Inhibition of the NF-κB Signaling Pathway: In Vitro and In Vivo Studies

Chalcones: Promising therapeutic agents targeting key players and signaling pathways regulating the hallmarks of cancer

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Chemopreventive effect of 4'‑hydroxychalcone on intestinal tumorigenesis in Apc^Min mice