Chemopreventive effect of montelukast in n-nitroso n-methyl urea induced mammary carcinogenesis in female Sprague-Dawley rats

Abstract

Objective:The objective of the study was to evaluate the chemopreventive effect of montelukast sodium; selective reversible cysteinyl leukotriene D4-receptor antagonist in N-nitroso N-methyl urea (NMU) induced mammary carcinogenesis in virgin female Sprague-Dawley rats.Materials and Methods:Thirty rats were divided into five groups (normal control, disease control, montelukast1 mg/kg, montelukast10 mg/kg, tamoxifen10 mg/kg) of six animals each. The drug was administered in two doses,1 mg/kg,and 10 mg/kg orally and compared with the standard drug tamoxifen (10 mg/kg)p.o.Results:Montelukast sodium 1 mg/kg,10 mg/kg, and tamoxifen10 mg/kg decreased the tumor incidences by 50%,66.67%, and 83.33% and the total number of tumors in group by 41.67%, 58.33% and 91.67% respectively, when compared to the disease control. Montelukast sodium 1 mg/kg,10 mg/kg,and tamoxifen10 mg/kg decreased the average tumor burden by 86.41%,94.8% and 95.97%and average tumor volume by 89.52%, 95.84%, and 95.4%respectively, when compared to disease control group.Conclusion:The results revealed that montelukast sodium prevent the mammary carcinogenesis and confirms the role of cysteinyl leukotriene D4-receptor in mammary gland neoplasia.

Montelukast Induces Apoptosis-Inducing Factor-Mediated Cell Death of Lung Cancer Cells

“…Only a few in vivo studies in the literature to date have shown the chemo-preventive effect of leukotriene pathway inhibitors [ 12 , 13 , 14 , 15 ]. An early study using a mouse model of vinyl carbamate-inducing lung tumors demonstrated the chemo-preventive effect of leukotriene pathway inhibitors, including accolate (zafirlukast), zileuton, and MK-866 [ 13 ].…”

“…An early study using a mouse model of vinyl carbamate-inducing lung tumors demonstrated the chemo-preventive effect of leukotriene pathway inhibitors, including accolate (zafirlukast), zileuton, and MK-866 [ 13 ]. A recent study using a mouse model of n -nitroso n -methyl urea-inducing mammary carcinogenesis also demonstrated the chemo-preventive effect of montelukast [ 15 ]. In a study using a peripheral spontaneous metastasis model, LLC cells were inoculated into the foot pad of mice; after the tumor-inoculated foot was amputated, mice given pranlukast or montelukast had a significantly prolonged survival than the mice in the control group [ 14 ].…”

“…The leukotriene pathway, in addition to its well-known role in allergic disease, is also responsible for carcinogenesis and tumor-mediated immune-suppression [ 6 ]. Few in vitro studies have shown the anti-cancer effect of montelukast in various genital and urological cancer cells [ 7 , 8 , 9 , 10 , 11 , 12 ], and only a few in vivo studies have reported the anti-cancer effect of leukotriene pathway inhibitors [ 12 , 13 , 14 , 15 ]. However, the effect of montelukast on lung cancer has not been studied yet, and its underlying anti-cancer mechanisms have not been fully understood.…”

Bioactive lipids and cancer metastasis to bone

“…A large epidemiological study on asthmatic patients showed that LTRA treatments decreased the risk of cancer development, especially lung, breast, colorectal, and liver cancers [179] . CYSLT1 antagonists also confer promising chemopreventive effects in preclinical models [180][181][182][183][184] .…”

Kontrowersje wokół długoterminowych badań Gillesa-Erica Séraliniego nad bezpieczeństwem zdrowotnym kukurydzy GMO

“…Przykładowo, szczury te wielokrotnie wykorzystywano w badaniach nad chemicznie indukowanym rakiem gruczołu mlekowego (De Jonage-Canonico et al 2003;Jakubowski et al 2002;Kubatka et al 2001;Faustino-Rocha et al 2013). Możliwości chemoprewencji raka gruczołu mlekowego u szczurów SD badały także dwa inne zespoły (Jose et al 2013;Dias et al 2013). Na szczurach tego szczepu badano też wpływ toestrogenów zawartych w diecie na sygnalizację hormonalną (Casanova et al 1999) czy wpływ atrazyny (Wetzel et al 1994) oraz kwasu foliowego (Deghan Manshadi et al, 2014) na rozwój guzów gruczołu mlekowego.…”