Chemopreventive effect of oltipraz on AFB<sub>1</sub>-induced hepatocarcinogenesis in tree shrew model

Li, Yuan; Su, Jian; Qin, Liu Liang; Yang, Chun; Luo, Di; Ban, Ke Chen; Tw, Kensler; Bd, Roebuck

doi:10.3748/wjg.v6.i5.647

Cited by 11 publications

(1 citation statement)

References 38 publications

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“…These results demonstrate a synergistic effect of HBV and AFB1 in the development of primary hepatocellular carcinoma. Later, it was also found that the hepatocellular carcinogenesis induced by AFB1 in tree shrews was significantly inhibited by oltipraz, and the gene expression profile of hepatocellular carcinoma induced by different factors was also different ( 76 , 77 ). Differential gene expression was predominantly upregulated in the AFB1 group and downregulated in the AFB1+HBV group.…”

Section: Methods For Constructing Tree Shrew Cancer Models and Their mentioning

confidence: 99%

The Tree Shrew as a Model for Cancer Research

Peng

Zhong

et al. 2021

Front. Oncol.

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Animal disease models are necessary in medical research, and an appropriate animal model is of great importance for studies about the prevention or treatment of cancer. The most important thing in the selection of animal models is to consider the similarity between animals and humans. The tree shrew (Tupaia belangeri) is a squirrel-like mammal which placed in the order Scandentia. Whole-genome sequencing has revealed that tree shrews are extremely similar to primate and humans than to rodents, with many highly conserved genes, which makes the data from studies that use tree shrews as models more convincing and the research outcomes more easily translatable. In tumor research, tree shrews are often used as animal models for hepatic and mammary cancers. As research has progressed, other types of tree shrew tumor models have been developed and exhibit clinical manifestations similar to those of humans. Combining the advantages of both rodents and primates, the tree shrew is expected to be the most powerful animal model for studying tumors.

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Section: Methods For Constructing Tree Shrew Cancer Models and Their mentioning

confidence: 99%

The Tree Shrew as a Model for Cancer Research

Peng

Zhong

et al. 2021

Front. Oncol.

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Characterization of tree shrew telomeres and telomerase

Sun

Liu

Guo

et al. 2021

Journal of Genetics and Genomics

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Characterization and phylogenetic analysis of Krüppel-like transcription factor (KLF) gene family in tree shrews (Tupaia belangeri chinensis)

Shao

Liu

et al. 2016

Oncotarget

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Krüppel-like factors (KLFs) are a family of zinc finger transcription factors regulating embryonic development and diseases. The phylogenetics of KLFs has not been studied in tree shrews, an animal lineage with a closer relationship to primates than rodents. Here, we identified 17 KLFs from Chinese tree shrew (Tupaia belangeri chinensis). KLF proteins are highly conserved among humans, monkeys, rats, mice and tree shrews compared to zebrafish and chickens. The CtBP binding site, Sin3A binding site and nuclear localization signals are largely conserved between tree shrews and human beings. Tupaia belangeri (Tb) KLF5 contains several conserved post-transcriptional modification motifs. Moreover, the mRNA and protein expression patterns of multiple tbKLFs are tissue-specific. TbKLF5, like hKLF5, significantly promotes NIH3T3 cell proliferation in vitro. These results provide insight for future studies regarding the structure and function of the tbKLF gene family.

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Chemopreventive effect of oltipraz on AFB₁-induced hepatocarcinogenesis in tree shrew model

Cited by 11 publications

References 38 publications

The Tree Shrew as a Model for Cancer Research

The Tree Shrew as a Model for Cancer Research

Characterization of tree shrew telomeres and telomerase

Characterization and phylogenetic analysis of Krüppel-like transcription factor (KLF) gene family in tree shrews (Tupaia belangeri chinensis)

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Chemopreventive effect of oltipraz on AFB1-induced hepatocarcinogenesis in tree shrew model

Cited by 11 publications

References 38 publications

The Tree Shrew as a Model for Cancer Research

The Tree Shrew as a Model for Cancer Research

Characterization of tree shrew telomeres and telomerase

Characterization and phylogenetic analysis of Krüppel-like transcription factor (KLF) gene family in tree shrews (Tupaia belangeri chinensis)

Contact Info

Product

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Chemopreventive effect of oltipraz on AFB₁-induced hepatocarcinogenesis in tree shrew model