Chemopreventive effect of Toona sinensis leaf extract on 7,12-dimethylbenz[a]anthracene-induced hamster buccal pouch squamous cell carcinogenesis

Wang, Wen-Chen; Chen, Ching-Yi; Hsu, Hseng‐Kuang; Lin, Li‐Min; Chen, Yuk-Kwan

doi:10.1016/j.archoralbio.2016.06.015

Cited by 10 publications

(5 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In the current study, the duration of DMBA application was carefully planned according to the previous literatures, at 8 weeks for the animals of GII A in order to achieve development of intact epithelial dysplasia, but not invasive SCC, and at 14 weeks for the animals of GII B in order to achieve development of invasive OSCC (16,17) . In the present study, the chemopreventive agent has been administered one week before and during carcinogen administration following the protocol of previous studies (18,19) .…”

Section: Discussionmentioning

confidence: 99%

Efficacy of Hydroxytyrosol as Chemopreventive Agent on Induced Hamster Buccal Pouch Carcinogenesis

Abd-Alwahab

Ahmed

Zouair

2019

Al-Azhar Assiut Dental Journal

View full text Add to dashboard Cite

Aim: It was to investigate the efficacy of hydroxytyrosol (HT) as chemopreventive agent on induced hamster buccal pouch (HBP) carcinogenesis. Subjects and Methods: Forty Syrian male hamsters five weeks old, weighing 80-120g, were divided into three groups. GI: 10 animals were left untreated. GII: 10 animals were painted with 0.5% 7, 12-dimethylbenz(a)anthracene (DMBA) in paraffin oil, 3 times a week, for 8 weeks (GIIA) and14 weeks (GIIB). GIII: chemoprevention group, 20 animals in which HT was taken at week before as well as during the application of DMBA, 3 times a week on alternative days, for 8 weeks (GIIIA) and14 weeks (GIIIB). HPB mucosa were excised and trimmed to 1-2 cm average size, then processed for hematoxylin and eosin (H&E) stain and Immunohistochemical (IHC) staining utilizing Bcl-2 and Bak antibodies. Results: Gross observation revealed variable changes in the treated (G (s)), (GII and GIII) compared to that observed in GI. Histopathological findings revealed variations among the treated groups. IHC results regarding Bcl-2 expression revealed variability in the area percentage throughout the used groups. GI, GIIA, GIIB, GIIIA and GIIIB were (6.77٪, 31.58٪, 68.37٪, 16.07٪, 48.81٪) respectively, while IHC results regarding Bak expression revealed variability in the area percentage throughout the used groups. GI, GIIA, GIIB, GIIIA and GIIIB were (45.32%, 28.58%, 10.38%, 19.32%, 38.72%) respectively. Conclusion: HT is considered as a promising chemopreventive agent in decrease the incidence of HBP carcinogenesis in gross observation as well as in histological examination.

show abstract

Section: Discussionmentioning

confidence: 99%

Efficacy of Hydroxytyrosol as Chemopreventive Agent on Induced Hamster Buccal Pouch Carcinogenesis

Abd-Alwahab

Ahmed

Zouair

2019

Al-Azhar Assiut Dental Journal

View full text Add to dashboard Cite

show abstract

“…In addition, TSL aqueous extracts can inhibit the proliferation and induce the apoptosis of hamster cheek pouch squamous cell carcinoma induced by 7,12-dimethylbenz[a]anthracene (DMBA). Downregulation of the protein expression of survivin, X chromosome-linked inhibitor of apoptosis (XIAP), proliferating cell nuclear antigen (PCNA), iNOS and COX-2 and increased apoptotic activity suggested that TSL therapy might aid the prevention of oral cancer [86].…”

Section: Antitumor Activitymentioning

confidence: 99%

Traditional Uses, Chemical Constituents and Pharmacological Activities of the Toona sinensis Plant

Zhao,

Li,

Wang

et al. 2024

Molecules

View full text Add to dashboard Cite

Toona sinensis (A. Juss.) Roem., which is widely distributed in China, is a homologous plant resource of medicine and food. The leaves, seeds, barks, buds and pericarps of T. sinensis can be used as medicine with traditional efficacy. Due to its extensive use in traditional medicine in the ancient world, the T. sinensis plant has significant development potential. In this review, 206 compounds, including triterpenoids (1–133), sesquiterpenoids (134–135), diterpenoids (136–142), sterols (143–147), phenols (148–167), flavonoids (168–186), phenylpropanoids (187–192) and others (193–206), are isolated from the T. sinensis plant. The mass spectrum cracking laws of representative compounds (64, 128, 129, 154–156, 175, 177, 179 and 183) are reviewed, which are conducive to the discovery of novel active substances. Modern pharmacological studies have shown that T. sinensis extracts and their compounds have antidiabetic, antidiabetic nephropathy, antioxidant, anti-inflammatory, antitumor, hepatoprotective, antiviral, antibacterial, immunopotentiation and other biological activities. The traditional uses, chemical constituents, compound cracking laws and pharmacological activities of different parts of T. sinensis are reviewed, laying the foundation for improving the development and utilization of its medicinal value.

show abstract

“…In vivo studies with nobiletin on male BALB/c nude mice suppressed tumor formation and metastasis by downregulating NF-κB translocation, MMP-2, and TIMP-2 proteins, and decreased phosphorylation of ERK1/2 ( Chien et al, 2015 ). Toona sinensis crude extract decreased the incidences of SCCs, tumor number, tumor volume, and tumor burden in male Syrian golden hamsters by downregulating protein levels of survivin, XIAP, PCNA, iNOS, and COX-2 ( Wang et al, 2016 ). Delayed tumor initiation incidence was reported in bitter melon extract–fed mice ( Sur et al, 2018 ).…”

Section: Head and Neck Cancer Spectrummentioning

confidence: 99%

Phytochemicals as Potential Chemopreventive and Chemotherapeutic Agents for Emerging Human Papillomavirus–Driven Head and Neck Cancer: Current Evidence and Future Prospects

et al. 2021

View full text Add to dashboard Cite

Head and neck cancer (HNC) usually arises from squamous cells of the upper aerodigestive tract that line the mucosal surface in the head and neck region. In India, HNC is common in males, and it is the sixth most common cancer globally. Conventionally, HNC attributes to the use of alcohol or chewing tobacco. Over the past four decades, portions of human papillomavirus (HPV)-positive HNC are increasing at an alarming rate. Identification based on the etiological factors and molecular signatures demonstrates that these neoplastic lesions belong to a distinct category that differs in pathological characteristics and therapeutic response. Slow development in HNC therapeutics has resulted in a low 5-year survival rate in the last two decades. Interestingly, HPV-positive HNC has shown better outcomes following conservative treatments and immunotherapies. This raises demand to have a pre-therapy assessment of HPV status to decide the treatment strategy. Moreover, there is no HPV-specific treatment for HPV-positive HNC patients. Accumulating evidence suggests that phytochemicals are promising leads against HNC and show potential as adjuvants to chemoradiotherapy in HNC. However, only a few of these phytochemicals target HPV. The aim of the present article was to collate data on various leading phytochemicals that have shown promising results in the prevention and treatment of HNC in general and HPV-driven HNC. The review explores the possibility of using these leads against HPV-positive tumors as some of the signaling pathways are common. The review also addresses various challenges in the field that prevent their use in clinical settings.

show abstract

Chemopreventive effect of Toona sinensis leaf extract on 7,12-dimethylbenz[a]anthracene-induced hamster buccal pouch squamous cell carcinogenesis

Cited by 10 publications

References 28 publications

Efficacy of Hydroxytyrosol as Chemopreventive Agent on Induced Hamster Buccal Pouch Carcinogenesis

Efficacy of Hydroxytyrosol as Chemopreventive Agent on Induced Hamster Buccal Pouch Carcinogenesis

Traditional Uses, Chemical Constituents and Pharmacological Activities of the Toona sinensis Plant

Phytochemicals as Potential Chemopreventive and Chemotherapeutic Agents for Emerging Human Papillomavirus–Driven Head and Neck Cancer: Current Evidence and Future Prospects

Contact Info

Product

Resources

About