Chemopreventive Effects of Cabbage on 7,12-Dimethylbenz(a)-Anthracene-Induced Hepatocarcinogenesis in Toads (Bufo viridis).

Sadek, I.A.; Abdel-Salam, Fatma; Al-Qattan, Khalid

doi:10.3177/jnsv.41.163

Cited by 5 publications

(3 citation statements)

References 19 publications

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“…The potential of cruciferous vegetables and their chemical derivatives has been extensively reviewed by the International Agency for Research on Cancer (IARC, 2004). Dietary supplementation with cruciferous vegetables has been shown to consistently inhibit hepatocarcinogenesis induced by AFB 1 , 2-amino-3-methylimidazo[4,5-f] quinoline (IQ) and 7,12-dimethylbenz(a)anthracene (Boyd et al, 1982;Godlewski et al, 1985;Sadek et al, 1995;Kassie et al, 2003). In addition, a clinical trial has begun in the Qidong region of China to assess the impact of glucosinolate-rich broccoli sprouts on AFB 1 -induced hepatocarcinogenesis (Kensler et al, 2005).…”

Section: Cruciferous Vegetablesmentioning

confidence: 98%

Phytochemicals as potential chemopreventive and chemotherapeutic agents in hepatocarcinogenesis

Mann

Neal

Garcea

et al. 2009

European Journal of Cancer Prevention

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Hepatocellular carcinoma (HCC) is the fifth commonest malignancy worldwide and the incidence is rising. Surgery, including transplantation resection, is currently the most effective treatment for HCC; however, recurrence rates are high and long-term survival is poor. Identifying novel chemopreventive and chemotherapeutic agents and targeting them to patients at high risk of developing HCC or following curative treatment may go some way towards improving prognosis. This review examines current knowledge regarding the chemopreventive and chemotherapeutic potential of phytochemicals in heptocarcinogenesis. Both in-vitro and animal studies demonstrate that several phytochemicals, including curcumin, resveratrol, green tea catechins, oltipraz and silibinin, possess promising chemopreventive and chemotherapeutic properties. Despite this, very few clinical trials have been performed. Problems regarding validation of biomarkers, agent delivery, side effects and patient selection are barriers that need to be overcome to determine the potential of such agents in clinical practice.

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Section: Cruciferous Vegetablesmentioning

confidence: 98%

Phytochemicals as potential chemopreventive and chemotherapeutic agents in hepatocarcinogenesis

Mann

Neal

Garcea

et al. 2009

European Journal of Cancer Prevention

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“…capitata) is rich in antioxidants and can be utilized to prevent the toxicity of metals and their side effects (Eryilmazz et al, 2002). It plays an essential role in the treatment of various human and animal diseases, in addition to having anticarcinogenic, antitumor, antithrombotic, and hepatoprotective properties (Sadek and Al-Qattan, 1995).…”

Section: Introductionmentioning

confidence: 99%

The Role of Antioxidant Plant Extracts in Cadmium-Induced Testicular Injuries

Aljazzar¹,

Al-Shokair²,

Hussein³

et al. 2023

BAS-SJKFU

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The effects of cadmium (Cd) on testes were examined in rats injected subcutaneously with cadmium chloride (CdCl2) at a dosage of 7 mg/kg body weight. Following CdCl2 treatment, the rats were euthanized with phenobarbital sodium 24 hours post-injection, and their testes were subsequently removed and homogenized. The extent of hemorrhage was assessed by employing a spectrophotometer to measure the absorbance of hemoglobin at 414 nm in the soluble fraction of the organ homogenates. Exposure to Cd resulted in severe hemorrhage and increased hemoglobin absorbance in the testes of the treated animals. However, oral pre-treatment of different animal groups with various plant antioxidant extracts, such as ginger extract, pure garlic juice, pure broccoli juice, pure mint juice, and curcumin, administered in seven successive doses over seven days, significantly mitigated Cd-induced testicular hemorrhage. Consequently, it was concluded that the antioxidant properties of these plant extracts could effectively prevent cardiovascular damage to rat testes induced by Cd.

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“…As yet, no data are available concerning possible inducing or inhibitory properties of curcumin towards cytochrome P450s nor towards Glutathione S-Transferase GSTs, two of the most important enzyme systems involved in the bioactiviation and bioinactivation of xenobiotic compounds (Vermeulen et al, 1992). Toads have been used as models to study the development of tumors in relation to carcinogen (EI-Mofty et al, 1987), a co-carcinogen (Sadek and Abdul-Salam, 1994), vitamins (Sadek and Hayat, 1996) and substances originating from plant (Sadek et al, 1995). It is worth to mention that similarities in cytological characteristics between tumors in toads and humans have been documented (Abdelmeguid et al, 1997).…”

Section: Introductionmentioning

confidence: 99%

Curcumin and its Effect on Cytochrome P450 and GST in Toad Liver Tumor Induced by DMBA

Abdellatif¹,

Sadek²

1999

Pakistan J. of Biological Sciences

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Curcumin has been used as a colouring agent and spice in many food. The present results clearly demonstrated that toads received 0.5 mg curcumin and 0.5 mg DMBA/toad, 3 times/week for 12 weeks, showed a significant decrease in tumor incidence (3 out of 50 cases) in comparison with that treated with DMBA alone (12 out of 50 cases). At the same time, curcumin reduce the activity of liver microsomal cytochrome P450s and cytosolic GTSS enzymes in toads previously treated with DMBA. The present data suggest that curcumin decrease incidence of liver tumor in toads through inhibition of cytochrome P450 and GST activities. The present report was undertaken for two reasons. First to determine whether curcumin, which are widely used in food have anticarcinogenic effect on the liver of the Egyptian toad. Second, are curcumin effect on microsomal cytochrome P450 and GST activities to shed more light on the mechanisms (s) of action.

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Chemopreventive Effects of Cabbage on 7,12-Dimethylbenz(a)-Anthracene-Induced Hepatocarcinogenesis in Toads (Bufo viridis).

Cited by 5 publications

References 19 publications

Phytochemicals as potential chemopreventive and chemotherapeutic agents in hepatocarcinogenesis

Phytochemicals as potential chemopreventive and chemotherapeutic agents in hepatocarcinogenesis

The Role of Antioxidant Plant Extracts in Cadmium-Induced Testicular Injuries

Curcumin and its Effect on Cytochrome P450 and GST in Toad Liver Tumor Induced by DMBA

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