Chemopreventive effects of β-ionone and geraniol during rat hepatocarcinogenesis promotion: distinct actions on cell proliferation, apoptosis, HMGCoA reductase, and RhoA

Cardozo, Mônica Testoni; Conti, Aline de; Ong, Thomas Prates; Scolastici, Clarissa; Purgatto, Eduardo; Horst, Maria Aderuza; Bassoli, Bruna Kempfer; Moreno, Fernando Salvador

doi:10.1016/j.jnutbio.2009.12.007

Cited by 66 publications

(59 citation statements)

References 32 publications

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“…To the best of our knowledge, in vivo studies of chemoprevention with GO have only been conducted in liver, breast and pancreas carcinogenesis models, with inhibition of hepatic PNLs (9,10) and mammary (11,34) and pancreatic (12) neoplastic lesions, respectively. Recently, βI was reported to have chemopreventive activity in liver (8,10), breast (3,11) and colon (14) carcinogenesis. However, inhibition of total ACF and of ACF <4 or ACF ≥4 crypts by βI was not observed in the present study.…”

Section: Discussionmentioning

confidence: 99%

“…The induction of apoptosis via the Bcl-2 family of proteins has been identified as one of the main mechanisms of action of isoprenoids, as observed for perillyl alcohol, geranylgeraniol and farnesol (21,22). It is important to highlight the lack of in vivo studies addressing the capacity of apoptosis modulation by GO, as induced in hepatic PNL (9,10). Moreover, since apoptosis is a cellular event that involves activation and/or suppression of various gene families (23), it would be important to determine the influence of GO on other members of the Bcl-2 family, including pro-apoptotic ones such as Bax (22).…”

Section: Discussionmentioning

confidence: 99%

“…Immediately after collection, it was placed in centrifuge tubes containing 5 mg EDTA and centrifuged at 3500 g, 4°C for 10 min. Total plasma cholesterol concentration was determined using an enzymatic-spectrophotometric technique (10). Analysis was performed at 500 nm with a Hitachi U 110 spectrophotometer (Japan).…”

Section: Total Plasma Cholesterol Concentrationmentioning

confidence: 99%

“…In the few available in vivo studies, both compounds exerted chemopreventive activity against hepatocarcinogenesis in rats ( [8][9][10]. GO inhibited the growth of mammary and pancreatic neoplasms in rats and hamsters, respectively (11,12), and proved to be an effective adjuvant in the treatment with 5-fluorouracil of human colorectal cancer cells transplanted in Swiss nu/ nu mice (13).…”

mentioning

confidence: 99%

“…Because βI and GO had chemopreventive activity in different models (8)(9)(10)12), including colon carcinogenesis in the case of βI (14), we hypothesized that the combination of βI and GO could result in synergistic chemopreventive activity. Therefore, we investigated the chemopreventive potential of the combination of βI and GO during the initiation and postinitiation phases of a rat colon carcinogenesis model induced by dimethylhydrazine (DMH).…”

mentioning

confidence: 99%

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Efficacy of geraniol but not of β-ionone or their combination for the chemoprevention of rat colon carcinogenesis

Vieira¹,

Heidor

Cardozo

et al. 2011

Braz J Med Biol Res

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Total Plasma Cholesterol Concentrationmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Efficacy of geraniol but not of β-ionone or their combination for the chemoprevention of rat colon carcinogenesis

Vieira¹,

Heidor

Cardozo

et al. 2011

Braz J Med Biol Res

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Comparative study on the free radical scavenging mechanism exerted by geraniol and geranylacetone using the combined experimental and theoretical approach

Stobiecka

2015

Flavour & Fragrance J

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In the current study the free radical scavenging mechanism of geraniol and geranylacetone has been investigated experimentally and theoretically. Two fragrant acyclic terpenoids were subjected to the ABTS and DPPH assay. Furthermore, the detailed quantum chemical calculations have been undertaken in order to evaluate the possible pathways underlying the radical scavenging activity of selected compounds in the non‐polar and polar media. The density functional theory (DFT) using the hybrid Becke three‐parameter exchange‐correlation functional (B3LYP) was applied. In general both investigated compounds possessed very weak anti‐radical activity at the applied experimental conditions but geranylacetone was significantly more effective as a ABTS•+ and DPPH• scavenger than geraniol. The comparison of DFT‐predicted reaction enthalpies associated with the hydrogen atom transfer mechanism (HAT), the single electron and proton transfer process (SET‐PT) and the sequential proton loss electron‐transfer (SPLET), revealed that the former mechanism should be favoured in geraniol solvated in both the non‐polar and polar media. On the contrary, an anti‐radical activity of geranylacetone in the non‐polar solvent was ascribed to the hydrogen donation mechanism while in the polar solvent it was assigned to the SPLET. According to the computational results the presence of allylic H‐atom (at the position 1C) close to the –OH group seemed to be essential for the observed anti‐radical activity of geraniol. The scavenging ability of geranylacetone was associated with the presence of both allylic and alkylic hydrogens in the close vicinity of the carbonyl functionality. Copyright © 2015 John Wiley & Sons, Ltd.

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Protective effects of geraniol (a monoterpene) in a diabetic neuropathy rat model: Attenuation of behavioral impairments and biochemical perturbations

Prasad

Muralidhara

2014

J of Neuroscience Research

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Involvement of oxidative stress, inflammatory response, and mitochondrial dysfunction in the development of diabetic neuropathy (DN) is well appreciated. The present study examines the potential of geraniol (GE), a well-known phytoconstituent commonly found in lemon, spices, rose oil, etc., to attenuate DN-associated oxidative/nitrosative stress by employing a streptozotocin (STZ) diabetic rat model. STZ-induced diabetic rats provided with oral supplements of GE (100 mg/kg bw/day, 8 weeks) exhibited significant improvement in tail-flick latency (sensory function) and the narrow beam test (motor function). Terminally, elevated levels of oxidative markers (reactive oxygen species, malondialdehyde, hydroperoxides) in cytosol of the sciatic nerve (SN) and in selected regions of the brain of diabetic rats were markedly reduced by GE supplements. Furthermore, GE significantly diminished the levels of protein carbonyls (a measure of protein oxidation) and nitrites in diabetic rats. In addition, in mitochondria, GE supplements restored the activities of enzymes, such as complexes I-III, succinate dehydrogenase, and citrate synthase, in brain regions of diabetic rats, with a concomitant reduction in the levels of oxidative markers. GE significantly lowered the enhanced cytosolic calcium levels and acetylcholinesterase activity in the SN and the brain regions of diabetic rats. Depleted dopamine levels evident in the SN and the cortex/striatum among diabetic rats were restored by GE. From our data, we hypothesize that GE may be a promising therapeutic candidate in the management of DN in humans. Further understanding of the molecular mechanisms of its neuromodulatory effects is essential in order to exploit its therapeutic efficacy.

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Chemopreventive effects of β-ionone and geraniol during rat hepatocarcinogenesis promotion: distinct actions on cell proliferation, apoptosis, HMGCoA reductase, and RhoA

Cited by 66 publications

References 32 publications

Efficacy of geraniol but not of β-ionone or their combination for the chemoprevention of rat colon carcinogenesis

Efficacy of geraniol but not of β-ionone or their combination for the chemoprevention of rat colon carcinogenesis

Comparative study on the free radical scavenging mechanism exerted by geraniol and geranylacetone using the combined experimental and theoretical approach

Protective effects of geraniol (a monoterpene) in a diabetic neuropathy rat model: Attenuation of behavioral impairments and biochemical perturbations

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