Chemopreventive mechanisms of galangin against hepatocellular carcinoma: A review

Fang, Dengyang; Xiong, Zuming; Xu, Jinming; Yin, Jun; Luo, Runlan

doi:10.1016/j.biopha.2018.09.154

Cited by 76 publications

(51 citation statements)

References 107 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Several epidemiological studies in vitro and animal studies have claimed that galangin and the consumption of galangin-containing foods may affect several diseases [ 171 ]. Galangin has a broad range of biological properties, including anti-oxidative and free radical scavenging, modulating enzyme activities, suppressing chemical genotoxicity, inhibitory effects on various microbes, the control of hypertension, diabetes, and chemoprevention of several cancers anti-inflammatory and anti-fibrotic activities in various disorders [ 172 – 174 ]. Galangin attenuated in vitro and in vivo airway remodeling by inhibiting TGF-β1-mediated ROS generation and MAPK/Akt phosphorylation in asthma; also, galangin improved ovalbumin (OVA)-induced airway inflammation by inhibiting NF-κB pathway, which reduced eosinophils, neutrophils, and lymphocytes infiltration and goblet cell hyperplasia.…”

Section: Galanginmentioning

confidence: 99%

The upshot of Polyphenolic compounds on immunity amid COVID-19 pandemic and other emerging communicable diseases: An appraisal

Khalil

Tazeddinova

2020

Nat. Prod. Bioprospect.

View full text Add to dashboard Cite

Polyphenols are a large family of more than 10,000 naturally occurring compounds, which exert countless pharmacological, biological and physiological benefits for human health including several chronic diseases such as cancer, diabetes, cardiovascular, and neurological diseases. Their role in traditional medicine, such as the use of a wide range of remedial herbs (thyme, oregano, rosemary, sage, mint, basil), has been well and long known for treating common respiratory problems and cold infections. This review reports on the most highlighted polyphenolic compounds present in up to date literature and their specific antiviral perceptive properties that might enhance the body immunity facing COVID-19, and other viral infectious diseases. In fact, several studies and clinical trials increasingly proved the role of polyphenols in controlling numerous human pathogens including SARS and MERS, which are quite similar to COVID-19 through the enhancement of host immune response against viral infections by different biological mechanisms. Thus, polyphenols ought to be considered as a potential and valuable source for designing new drugs that could be used effectively in the combat against COVID‐19 and other rigorous diseases.

show abstract

Section: Galanginmentioning

confidence: 99%

The upshot of Polyphenolic compounds on immunity amid COVID-19 pandemic and other emerging communicable diseases: An appraisal

Khalil

Tazeddinova

2020

Nat. Prod. Bioprospect.

View full text Add to dashboard Cite

show abstract

“…In some tumors, ER stress activates a series of compensatory mechanisms, and discovered that Hypoxia, oxidative stress and drugs can induce ER stress and cleaved-caspase-3 can promotes apoptosis by promotion the expression of GRP78 and CHOP protein in some tumors. [18][19][20][21] Recent research suggests that ER stress may be related to the molecular mechanism of tumor drug resistance. [22][23][24][25] In our study, Delicaflavone could enhance A549/DDP and PC9/DDP cells apoptosis by Flow cytometry assay, Western blots showed that delicaflavone overcame DDP resistance by increasing the expression of GRP78 and CHOP and the apoptosisrelated protein cleaved caspase-3.…”

Section: Dovepressmentioning

confidence: 99%

<p>Delicaflavone Reverses Cisplatin Resistance via Endoplasmic Reticulum Stress Signaling Pathway in Non-Small Cell Lung Cancer Cells</p>

Wang

Chen

et al. 2020

OTT

View full text Add to dashboard Cite

Background: The incidence and mortality of lung cancer continue to increase around the world; in 2018, new lung cancer cases accounted for 11.6% of all cancer cases, and lung cancer deaths accounted for 18.4% of cancer deaths. Cisplatin (DDP) is a first-line chemotherapy drug for lung cancer; however, DDP resistance can lead to a poor prognosis in patients with lung cancer. Therefore, reversing DDP resistance is a treatment goal. Materials and Methods: Cell counting kit-8 (CCK8) assays, wound healing analyses, Transwell assays, in vitro tumor xenografts, and flow cytometry were used to detect the proliferation, migration, invasion, and apoptosis of multidrug resistant A549/DDP and PC9/ DDP cells, respectively. Western blot was performed to detect protein levels of cleaved caspase-3, CHOP, and GRP78. Results: Delicaflavone inhibited DDP resistance of lung cancer cells and decreased proliferation in a dose-and time-dependent manner. It also decreased migration and invasion and enhanced apoptosis. Western blots showed that delicaflavone overcame DDP resistance by increasing the expression of GRP78 and CHOP and the apoptosis-related protein cleaved caspase-3. Conclusion: Delicaflavone can reverse DDP resistance in A549/DDP and PC9/DDP cells by inhibiting cell proliferation and migration and enhancing apoptosis and cleaved caspase-3 levels by increasing the expression of CHOP and GRP78 protein via the endoplasmic reticular stress pathway. It could be a useful therapeutic adjunct to treat DDP-resistant lung cancer.

show abstract

“…Nevertheless, propolis contains numerous flavonoids, and there is scant information regarding the active constituents in relation to its gastrointestinal effects. Galangin (3,5,7-trihydroxyflavone) is one flavonol identified as a major active phytochemical in propolis and Alpinia officinarum Hance (Galangal) [12]. Recent studies have shown that galangin confers some effects towards suppressing the pathogenesis of UC induced by dextran sulphate sodium (DSS) via the inhibition of inflammation [13].…”

Section: Introductionmentioning

confidence: 99%

Galangin Protects against Symptoms of Dextran Sodium Sulfate-Induced Acute Colitis by Activating Autophagy and Modulating the Gut Microbiota

Han

Hao

et al. 2020

Nutrients

View full text Add to dashboard Cite

Galangin is a natural flavonoid that has been reported to provide substantial health benefits. Nevertheless, little is known about the potential effects of galangin against inflammatory bowel diseases. Here, an in vivo study was performed to investigate the preventive effects of galangin against dextran sulphate sodium (DSS)-induced acute murine colitis, which mimics the symptoms of human ulcerative colitis (UC). Pre-treatment with galangin (15 mg/kg, p.o.) resulted in a significant decreased in the macroscopic signs of DSS-induced colitic symptoms, including a decreased disease activity index, prevention of the colon length shortening, and alleviation of the pathological changes occurring in the colon. Colonic pro-inflammatory mediators, including tumor necrosis factor-alpha, interleukin (IL)-1 beta, and IL-6, as well as myeloperoxidase activities were decreased following galangin pre-treatment when compared with the DSS control group. Moreover, galangin pre-treatment significantly increased the expressions of autophagy-related proteins and promoted the formation of autophagosome in the colon. Galangin pre-treatment increased the diversity of the gut microbiota, and this was accompanied by increased levels of short-chain fatty acids. These observed changes could involve the modulating effects conferred by galangin in relation to some specific bacteria populations, including the recovery of Lactobacillus spp., and increased Butyricimonas spp. Overall, these results support the use of galangin in the prevention of UC.

show abstract

Chemopreventive mechanisms of galangin against hepatocellular carcinoma: A review

Cited by 76 publications

References 107 publications

The upshot of Polyphenolic compounds on immunity amid COVID-19 pandemic and other emerging communicable diseases: An appraisal

The upshot of Polyphenolic compounds on immunity amid COVID-19 pandemic and other emerging communicable diseases: An appraisal

<p>Delicaflavone Reverses Cisplatin Resistance via Endoplasmic Reticulum Stress Signaling Pathway in Non-Small Cell Lung Cancer Cells</p>

Galangin Protects against Symptoms of Dextran Sodium Sulfate-Induced Acute Colitis by Activating Autophagy and Modulating the Gut Microbiota

Contact Info

Product

Resources

About