Chemopreventive potential of piperine in 7,12-dimethylbenz[a]anthracene-induced skin carcinogenesis in Swiss albino mice

Vellaichamy, Lakshmanan; Sadasivam, Balakrishnan; Panjamurthy, Kuppusamy; Manoharan, Shanmugam; Alias, Linsa Mary

doi:10.1016/j.etap.2009.01.008

Cited by 30 publications

(12 citation statements)

References 39 publications

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“…Alkaloids have long been used as a reservoir for drug discovery infrastructure and, some of these alkaloids have already been approved by the US Food and Drug Administration (FDA), such as camptothecin, a famous inhibitor of topoisomerase I, and vinblastine, which interacts with tubulin leading to mitotic catastrophe (Lu et al, 2012 ). The cancer preventive impacts of piperine against a few sorts of cancer-causing agents, for example, 7,12-dimethyl benz(a)anthracene and benzo(a)pyrene, demonstrate its potential as a cancer chemopreventive agent (Selvendiran et al, 2004 ; Vellaichamy et al, 2009 ). To better understand the mechanistic role of piperine in cancer chemoprevention, it will be useful to know how cancer develops.…”

Section: Importance Of Piperine In Foodmentioning

confidence: 99%

Cancer Chemoprevention and Piperine: Molecular Mechanisms and Therapeutic Opportunities

Rather

Bhagat

2018

Front. Cell Dev. Biol.

147

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Cancer is a genetic disease characterized by unregulated growth and dissemination of malignantly transformed neoplastic cells. The process of cancer development goes through several stages of biochemical and genetic alterations in a target cell. Several dietary alkaloids have been found to inhibit the molecular events and signaling pathways associated with various stages of cancer development and therefore are useful in cancer chemoprevention. Cancer chemoprevention has long been recognized as an important prophylactic strategy to reduce the burden of cancer on health care system. Cancer chemoprevention assumes the use of one or more pharmacologically active agents to block, suppress, prevent, or reverse the development of invasive cancer. Piperine is an active alkaloid with an excellent spectrum of therapeutic activities such as anti-oxidant, anti-inflammatory, immunomodulatory, anti-asthmatic, anti-convulsant, anti-mutagenic, antimycobacterial, anti-amoebic, and anti-cancer activities. In this article, we made an attempt to sum up the current knowledge on piperine that supports the chemopreventive potential of this dietary phytochemical. Many mechanisms have been purported to understand the chemopreventive action of piperine. Piperine has been reported to inhibit the proliferation and survival of many types of cancer cells through its influence on activation of apoptotic signaling and inhibition of cell cycle progression. Piperine is known to affect cancer cells in variety of other ways such as influencing the redox homeostasis, inhibiting cancer stem cell (CSC) self-renewal and modulation of ER stress and autophagy. Piperine can modify activity of many enzymes and transcription factors to inhibit invasion, metastasis, and angiogenesis. Piperine is a potent inhibitor of p-glycoprotein (P-gp) and has a significant effect on the drug metabolizing enzyme (DME) system. Because of its inhibitory influence on P-gp activity, piperine can reverse multidrug resistance (MDR) in cancer cells and acts as bioavailability enhancer for many chemotherapeutic agents. In this article, we emphasize the potential of piperine as a promising cancer chemopreventive agent and the knowledge we collected in this review can be applied in the strategic design of future researches particularly human intervention trials with piperine.

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Section: Importance Of Piperine In Foodmentioning

confidence: 99%

Cancer Chemoprevention and Piperine: Molecular Mechanisms and Therapeutic Opportunities

Rather

Bhagat

2018

Front. Cell Dev. Biol.

147

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“…Different mechanisms have been suggested, including apoptosis and suppression of metastasis [400], inhibition of angiogenesis [401], and blocked invasion by downregulation of MMPs [402,403]. Piperine exerts chemopreventive activity against some carcinogens including benzo(a)pyrene-induced lung carcinogenesis [404] and DMBA- induced skin carcinogenesis [405]. Piperine, with its low toxicity and potent anti-angiogenic activity, may be considered as a possible therapeutic agent in cancer prevention and treatment.…”

Section: Approachesmentioning

confidence: 99%

Cancer prevention and therapy through the modulation of the tumor microenvironment

Casey

Amedei

Aquilano

et al. 2015

Seminars in Cancer Biology

311

204

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Cancer arises in the context of an in vivo tumor microenvironment. This microenvironment is both a cause and consequence of tumorigenesis. Tumor and host cells co-evolve dynamically through indirect and direct cellular interactions, eliciting multiscale effects on many biological programs, including cellular proliferation, growth, and metabolism, as well as angiogenesis and hypoxia and innate and adapative immunity. Here we highlight specific biological processes that could be exploited as targets for the prevention and therapy of cancer. Specifically, we describe how inhibition of targets such as cholesterol synthesis and metabolites, reactive oxygen species and hypoxia, macrophage activation and conversion, indoleamine 2, 3-dioxygenase regulation of dendritic cells, vascular endothelial growth factor regulation of angiogenesis, fibrosis inhibition, endoglin, and Janus kinase signaling emerge as examples of important potential nexuses in the regulation of tumorigenesis and the tumor microenvironment that can be targeted. We have also identified therapeutic agents as approaches, in particular natural products such as berberine, resveratrol, onionin A, epigallocatechin gallate, genistein, curcumin, naringenin, desoxyrhapontigenin, piperine, and zerumbone, that may warrant further investigation to target the tumor microenvironment for the treatment and/or prevention of cancer.

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“…This DMBA, a polycyclic aromatic hydrocarbon, is currently the most frequently utilized initiating agent but additional agents can serve as chemical initiators. Systemic exposure of DMBA is generally effective; however, it is often applied topically to induce skin carcinogenesis in two-stage skin papillomagenesis murine models [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Investigating Therapeutic Potential ofTrigonella foenum-graecumL. as Our Defense Mechanism against Several Human Diseases

Goyal

Gupta

Chatterjee

2016

Journal of Toxicology

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Current lifestyle, stress, and pollution have dramatically enhanced the progression of several diseases in human. Globally, scientists are looking for therapeutic agents that can either cure or delay the onset of diseases. Medicinal plants from time immemorial have been used frequently in therapeutics. Of many such plants, fenugreek is one of the oldest herbs which have been identified as an important medicinal plant by the researchers around the world. It is potentially beneficial in a number of diseases such as diabetes, hypercholesterolemia, and inflammation and probably in several kinds of cancers. It has industrial applications such as synthesis of steroidal hormones. Its medicinal properties and their role in clinical domain can be attributed to its chemical constituents. The 3 major chemical constituents which have been identified as responsible for principle health effects are galactomannan, 4-OH isoleucine, and steroidal saponin. Numerous experiments have been carried out in vivo and in vitro for beneficial effects of both the crude chemical and of its active constituent. Due to its role in health care, the functional food industry has referred to it as a potential nutraceutical. This paper is about various medicinal benefits of fenugreek and its potential application as therapeutic agent against several diseases.

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Chemopreventive potential of piperine in 7,12-dimethylbenz[a]anthracene-induced skin carcinogenesis in Swiss albino mice

Cited by 30 publications

References 39 publications

Cancer Chemoprevention and Piperine: Molecular Mechanisms and Therapeutic Opportunities

Cancer Chemoprevention and Piperine: Molecular Mechanisms and Therapeutic Opportunities

Cancer prevention and therapy through the modulation of the tumor microenvironment

Investigating Therapeutic Potential ofTrigonella foenum-graecumL. as Our Defense Mechanism against Several Human Diseases

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