Chemoprophylaxis of COVID-19 with hydroxychloroquine - a study of health care workers attitude, adherence to regime and side effects

Bhattacharyya, Debajyoti; Raizada, Neeraj; Nagappa, Bharathnag; Tomar, Arvind; Maurya, Prateek; Chaudhary, Ashok; George, Mini; Katiyal, Deepty; Rajora, Srishti; Singh, Nikky

doi:10.1101/2020.06.11.20126359

Cited by 5 publications

(6 citation statements)

References 23 publications

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“…This finding was similar to the one reported by Bhattacharyya et al, who reported that the HCQ prophylaxis was accepted by 76% of the HCWs. Since our study included primarily doctors who were aware of the limited evidence of the effectiveness of HCQ prophylaxis against COVID-19, perhaps relatively lesser acceptance was observed [12]. About 70% of the participants knew the correct dose, duration, and contraindications associated with HCQ, but a screening test (ECG) was done only in half of the participants initiating HCQ prophylaxis.…”

Section: Table 1 Results Of Questions Related To Awareness Of Hcq Pro...mentioning

confidence: 99%

Doctors Perception of the Use of Hydroxychloroquine as Prophylaxis for COVID-19 Infection

Rana¹,

Ghadlinge²,

Singh³

et al. 2021

PBR

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Background: The National Task force constituted by the Indian Council of Medical Research (ICMR) and various International agencies has recommended the use of Hydroxychloroquine (HCQ) as prophylaxis for Coronavirus Disease 2019 (COVID-19). This measure was taken because of the urgent need to protect high-risk individuals like Health Care Workers (HCW) from contracting COVID-19. Objectives: This study aimed to assess the awareness, attitudes, and practices on using HCQ as prophylaxis to prevent COVID-19 infection. Methods: A cross-sectional study was conducted among the doctors working in Dr RML Hospital, New Delhi, India, a tertiary care public hospital involved in the care of COVID-19 patients. The invitation to participate was electronically circulated, and the consenting participants were allowed to access an online survey. The survey had a total of 23 questions that were designed to understand the awareness, perception, and practices of doctors regarding the use of HCQ as prophylaxis in COVID-19. Results: About 147 doctors participated in this survey. The major source of knowledge regarding HCQ prophylaxis was quoted as regulatory agencies (44%), particularly ICMR, and the main indication was reported as being a healthcare worker (60%). Most of the participants (91%) believed that the HCQ effect is not clear and felt more scientific data regarding the use of HCQ as prophylaxis for COVID-19. But many doctors (51%) still recommend using HCQ to their colleagues. Conclusion: In this study, we observed that most doctors were aware of the recommendations regarding the HCQ prophylaxis in COVID-19 and had good adherence to therapy but felt the need for more concrete scientific evidence for using HCQ.

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Section: Table 1 Results Of Questions Related To Awareness Of Hcq Pro...mentioning

confidence: 99%

Doctors Perception of the Use of Hydroxychloroquine as Prophylaxis for COVID-19 Infection

Rana¹,

Ghadlinge²,

Singh³

et al. 2021

PBR

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“…In a Delhi-based study, the authors found that doctors showed least acceptance of HCQ chemoprophylaxis. [17] The test of association performed between "compliance with the recommendation" and "gender" (χ 2 P = 0.68), "geographical region" (χ 2 P = 0.21), "practice setting" (χ 2 P = 0.24), and "specialty" (χ 2 P = 0.78) yielded non- Forty-three percent (n = 15) of respondents who work in the ICU stated that they took the chemoprophylaxis as per ICMRs recommendation. However, this percentage declined to 37 (n = 7) in outpatient clinics, 30 (n = 6) among respondents who work in emergency rooms, and 28 (n = 5) in inpatient wards.…”

Section: Discussionmentioning

confidence: 99%

“…[19] Bhattacharya et al (2020) reported that one in five health care workers who complied with the HCQ chemoprophylaxis developed mild side effects. [17] Dhamija et al reported that 36% of the respondents in their global survey reported side effects due to HCQ/chloroquine prophylaxis. [20] On the contrary, one study found no QT prolongation in health care workers who complied with the ICMRs chemoprophylaxis recommendation.…”

Section: Concerns About Side Effectsmentioning

confidence: 99%

“…They should strive to provide clear instructions in multiple languages, conduct awareness activities, discuss the effectiveness, explain the prophylaxis schedule, and issue guidelines on cessation. [17] Further, they shall collect and publish ongoing data in terms of efficacy of the recommendations. Recommendations without clarity may lead to adverse outcomes as strong statements televised through media may influence the health care workers perception and instill a false sense of confidence.…”

Section: Provide Claritymentioning

confidence: 99%

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Hydroxychloroquine as prophylaxis when treating patients with coronavirus disease 2019 – Perception of frontline health care workers in South India

Mani

Velan

2021

IJMS

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Objectives: In March 2020, the Indian Council of Medical Research (ICMR) recommended the use of hydroxychloroquine (HCQ) for prophylaxis in asymptomatic health care workers who care for suspected or confirmed patients and household contacts of confirmed patients with coronavirus disease 2019 (COVID-19). This recommendation was received by health-care practitioners with mixed opinions. The objectives of the study were to explore the views of frontline health-care practitioners (physicians, nurses, and physician assistants) in South India related to the ICMR recommendation of HCQ prophylaxis. Material and Methods: The survey research design was used to conduct this study. A ten-item electronic survey was developed based on the research question. The survey link was shared with frontline health-care practitioners in South India through email and WhatsApp messages identified through convenience sampling. Furthermore, the recipients were requested to forward the link to other frontline health-care professionals in their network (snowball sampling). Data were collected from April 16, 2020, to May 7, 2020. Results: The number of responses received was 132. Of 80 respondents who treated or anticipate treating patients with COVID-19, only 29 respondents reported that they complied with the ICMR’s HCQ chemoprophylaxis recommendation. Participants expressed concerns about the side effects and lack of conclusive evidence. Conclusion: Frontline health care workers in South India have mixed opinions with regard to the safety of HCQ prophylaxis. To promote the acceptance of and successful implementation of prophylaxis recommendations, it is essential that health authorities consider research evidence and seek stakeholder input before finalizing recommendations.

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“…Permission has been given by the FDA for the use of HCQ in severe COVID-19 cases. There are contradictory reports on the effectiveness of HCQ in COVID-19 therapy, and relatively few evidence on the safety and efficacy of COVID-19 chemoprophylaxis are available in the published literature [14][15][16].…”

Section: Discussionmentioning

confidence: 99%

Safety of Hydroxychloroquine for Covid-19 Prophylaxis Among Healthcare Workers: An Observational Study

Khanna¹,

Bewal²,

Arora³

et al. 2020

Asian J Pharm Clin Res

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Objective: Indian Council of Medical Research recommended hydroxychloroquine (HCQ) for prophylaxis of COVID‐19 for healthcare workers and the Food and Drug Administration approved its use in the treatment and prophylaxis of COVID‐19 disease. Even though HCQ is adequately tolerated in usual circumstances, still questions about the harmful effects of the drug remain a cause for concern in adults treated with HCQ. The objective of this study was to evaluate the major and minor adverse effects of prophylactic HCQ for COVID-19 among healthcare workers. Methods: Our analysis was intended to analyze HCQ’s adverse drug reaction profile for COVID‐19 prophylaxis in prophylactic doses in health-care staff. This was a cross-sectional study carried out among healthcare workers taking HCQ prophylaxis for COVID‑19. The study was carried out over 08 weeks period from April to May 2020. The data were obtained regarding age, sex, comorbidities, and possible adverse effects. A pretested and validated online questionnaire was provided to the participants to assess the harmful effects that they experienced when taking HCQ. Furthermore, pre and post 8 weeks prophylaxis, individuals underwent general and systemic examination, along with ECG and blood sugar level monitoring. Results: The research group comprised 70 previously healthy and health-care staff. In 70 patients, 27 minor adverse effects were reported (18.9%). Headache was the most frequently reported symptoms followed by nausea and vomiting, itching, and skin rashes. There was no statistically relevant variation in harmful effects due to age or number of doses administered. However, none of the adverse effects was serious or debilitating. Conclusion: With adequate pre-prophylaxis evaluation, health education, and regular monitoring, HCQ prophylaxis is safe and devoid of any serious adverse effects in previously healthy individuals.

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Chemoprophylaxis of COVID-19 with hydroxychloroquine - a study of health care workers attitude, adherence to regime and side effects

Cited by 5 publications

References 23 publications

Doctors Perception of the Use of Hydroxychloroquine as Prophylaxis for COVID-19 Infection

Doctors Perception of the Use of Hydroxychloroquine as Prophylaxis for COVID-19 Infection

Hydroxychloroquine as prophylaxis when treating patients with coronavirus disease 2019 – Perception of frontline health care workers in South India

Safety of Hydroxychloroquine for Covid-19 Prophylaxis Among Healthcare Workers: An Observational Study

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