Chemoprophylaxis of fascioliasis with triclabendazole

Boray, J. C.; Jackson, Robert S.; Strong, M B

doi:10.1080/00480169.1985.35224

Cited by 19 publications

(7 citation statements)

References 9 publications

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“…The reduction of the incidence of fasciolosis is consistent with other strategic dosing trials in cattle and sheep (Boray et al 1985;Fawcett 1990;Parr and Gray 2000). The high proportion of animals passing Fasciola eggs in cattle treated two times a year indicated the importance of an additional treatment at the middle of the dry season.…”

Section: Discussionsupporting

confidence: 81%

Effectiveness of strategic anthelmintic treatments in the control of gastrointestinal nematodes and Fasciola gigantica in cattle in Iringa region, Tanzania

Keyyu

Kyvsgaard²,

Monrad³

et al. 2008

Trop Anim Health Prod

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A longitudinal field trial was conducted to determine the effectiveness of strategic anthelmintic treatments in the control of gastrointestinal (GI) nematodes and Fasciola gigantica in cattle. A total of 167 cattle (6-18 months) from three large-scale dairy farms, four traditional farms and nine small-scale dairy farms were randomly selected. The selected animals on each farm were ear tagged and allocated into three groups based on live weight and treated as follows: Group T4 was treated with albendazole 10% drench at 10 mg/kg four times a year (mid rainy, end of the rain, mid dry and late dry/early rainy season). Group T2 was treated with albendazole 10% drench at 10 mg/kg two times a year (mid rainy and late dry/early rainy season). Group UT remained as untreated control. Faecal, blood and pasture samples were taken every month for 13 months. In addition, individual body weight (BWT) was measured on every sampling date. Results showed that two and four strategic treatments significantly reduced faecal egg counts (FEC) by 49.5% and 62.3% respectively compared to untreated control animals (P < 0.001). Two and four strategic treatments per year significantly reduced the proportion of animals passing Fasciola eggs in faeces by 30.6% and 51.7% (P < 0.001), respectively. Animals treated two and four times a year significantly outgained untreated animals by 14.8 kg and 17.7 kg respectively at the end of the trial (P < 0.05). The management system had a significant effect on packed cell volume and the proportion of animals passing Fasciola eggs in faeces (P < 0.05). The programme of two strategic treatments per year was only effective in controlling GI nematodes. It is concluded that a programme of four strategic treatments per year was effective in controlling GI nematodes and F. gigantica and improved weight gain.

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Section: Discussionsupporting

confidence: 81%

Effectiveness of strategic anthelmintic treatments in the control of gastrointestinal nematodes and Fasciola gigantica in cattle in Iringa region, Tanzania

Keyyu

Kyvsgaard²,

Monrad³

et al. 2008

Trop Anim Health Prod

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“…In the present study, the group treated with netobimin passed eggs in the faeces throughout the experiment but, with triclabendazole, egg-output ceased during 2±8 wpt. These results agree with those of Boray et al (1985) and Stans®eld et al (1987) for sheep infected with F. hepatica and treated with triclabendazole.…”

Section: Discussionsupporting

confidence: 82%

Effect of fasciolicides on the antigenaemia in sheep naturally infected with Fasciola hepatica

Sánchez-Andrade

Paz-Silvạ

et al. 2001

Parasitology Research

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A study was developed to evaluate the influence of triclabendazole (Fasinex) and netobimin (Hapasil) the antigenaemia in sheep naturally infected with Fasciola hepatica during 16 weeks. A sandwich-ELISA (enzyme-linked immunosorbent assay) using a rabbit polyclonal IgG antibody to F. hepatica antigens was employed and the data obtained were compared to those from coprological and indirect-ELISA techniques. Triclabendazole reduced the values of circulating antigens at weeks 2-4 post-treatment and faecal output at weeks 2-8 post-treatment, but antibodies showed positive values until the end of the study. Netobimin did not reduce circulating antigens of the trematode nor egg-excretion; and IgG antibodies did not decrease throughout the study.

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“…Triclabendazole (Fasinex@, Ciba-Geigy, Switzerland) is a new benzimidazole compound which has been shown to exhibit high efficacy against all stages of Fasciola hefiatica and Fasciola gigantica in sheep, goats and cattle (Boray et al, 1981;Wolff el al., 1983;Turner et al, 1984). Like other sulphide benzimidazoles, triclabendazole has been found to be oxidized to the sulphoxide and sulphone metabolites in sheep (Mohammed-Ali et al, 1986;Hennessy el al., 1987) and cattle (Bogan et al, 1985).…”

Section: Introductionmentioning

confidence: 99%

Pharmacokinetics and efficacy of triclabendazole in goats with induced fascioliasis

Kinab

1988

Vet Pharm & Therapeutics

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The pharmacokinetics of triclabendazole were evaluated in normal goats and in goats artificially infected with Fasciola hepatica. Triclabendazole and its metabolites were determined using a novel high performance liquid chromatographic method with fluorimetric detection after solid-phase extraction. In normal goats triclabendazole given orally was metabolized rapidly to its sulphoxide and sulphone derivatives. The maximum plasma concentrations for the sulphoxide and sulphone were similar ranging from 9 to 19 micrograms/ml and these were attained at an average 12.8 and 25.6 h, respectively, after administration. Both metabolites were eliminated slowly from plasma with elimination half-lives of 22.4 h for the sulphoxide and 19.4 h for the sulphone. They persisted at measurable concentrations in plasma for up to seven days. In milk, the two metabolites occurred in low concentrations and none of them was detectable (sulphoxide less than 0.04 microgram/ml, sulphone less than 0.02 microgram/ml) after seven days. The pharmacokinetic behaviour of triclabendazole was not altered in animals with fascioliasis. Efficacy of the drug against immature (six-week) F. hepatica was 100%.

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Chemoprophylaxis of fascioliasis with triclabendazole

Cited by 19 publications

References 9 publications

Effectiveness of strategic anthelmintic treatments in the control of gastrointestinal nematodes and Fasciola gigantica in cattle in Iringa region, Tanzania

Effectiveness of strategic anthelmintic treatments in the control of gastrointestinal nematodes and Fasciola gigantica in cattle in Iringa region, Tanzania

Effect of fasciolicides on the antigenaemia in sheep naturally infected with Fasciola hepatica

Pharmacokinetics and efficacy of triclabendazole in goats with induced fascioliasis

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