Chemoprotective activity of the isoflavones, genistein and daidzein on mutagenicity induced by direct and indirect mutagens in cultured HTC cells

Lepri, Sandra Regina; Luiz, Rodrigo Cabral; Zanelatto, Leonardo Campos; Silva, Patrícia Benites Gonçalves da; Sartori, Daniele; Ribeiro, Lúcia Regina; Mantovani, Mário Sérgio

doi:10.1007/s10616-012-9476-8

Cited by 22 publications

(11 citation statements)

References 46 publications

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“…Betacyanins are derivatives of betanidin, the conjugate of betalamic acid with cyclo-Dopa. Betacyanins, including amaranthin (183), betanin (184) and isobetanin (185), were confirmed in red and black quinoa seeds, instead of anthocyanins [35]. Betaxanthins are conjugates of betalamic acid with amino acids.…”

Section: Nitrogen-containing Metabolites and Their Biological Activitmentioning

confidence: 99%

Quinoa Secondary Metabolites and Their Biological Activities or Functions

et al. 2019

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Quinoa (Chenopodium quinoa Willd.) was known as the “golden grain” by the native Andean people in South America, and has been a source of valuable food over thousands of years. It can produce a variety of secondary metabolites with broad spectra of bioactivities. At least 193 secondary metabolites from quinoa have been identiﬁed in the past 40 years. They mainly include phenolic acids, ﬂavonoids, terpenoids, steroids, and nitrogen-containing compounds. These metabolites exhibit many physiological functions, such as insecticidal, molluscicidal and antimicrobial activities, as well as various kinds of biological activities such as antioxidant, cytotoxic, anti-diabetic and anti-inﬂammatory properties. This review focuses on our knowledge of the structures, biological activities and functions of quinoa secondary metabolites. Biosynthesis, development and utilization of the secondary metabolites especially from quinoa bran were prospected.

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Section: Nitrogen-containing Metabolites and Their Biological Activitmentioning

confidence: 99%

Quinoa Secondary Metabolites and Their Biological Activities or Functions

et al. 2019

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“…Therefore, these metabolites may help slugs in the intertidal zone with a high level of oxidative stress induced by desiccation during low tides 30 , 31 . Indeed, genistein showed antimutagenic effects with DNA damage agents at a concentration of 10 μM 32 . A similar bioactive flavonoid, apigenin, was also isolated from the intertidal aplysiid heterobranch Syphonota geographica (A. Adams and Reeve, 1850) (Aplysiidae, Tectipleura) and its food, the seagrass Halophila stipulacea (Forsskål) Ascherson, 1867 33 .…”

Section: Discussionmentioning

confidence: 99%

From Persian Gulf to Indonesia: interrelated phylogeographic distance and chemistry within the genus Peronia (Onchidiidae, Gastropoda, Mollusca)

Maniei

Moghaddam

Crüsemann

et al. 2020

Sci Rep

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the knowledge of relationships between taxa is essential to understand and explain the chemical diversity of the respective groups. Here, twelve individuals of the panpulmonate slug Peronia persiae from two localities in persian Gulf, and one animal of P. verruculata from Bangka island, indonesia, were analyzed in a phylogenetic and chemotaxonomic framework. Based on the ABGD test and haplotype networking using coi gene sequences of Peronia specimens, nine well-supported clades were found. Haplotype network analysis highlighted a considerable distance between the specimens of P. persiae and other clades. Metabolomic analysis of both species using tandem mass spectrometrybased GnpS molecular networking revealed a large chemical diversity within Peronia of different clades and localities. While P. persiae from different localities showed a highly similar metabolome, only few identical chemical features were found across the clades. the main common metabolites in both Peronia species were assigned as polypropionate esters of onchitriols and ilikonapyrones, and osmoprotectant amino acid-betaine compounds. On the other hand, the isoflavonoids genistein and daidzein were exclusively detected in P. persiae, while cholesterol and conjugated chenodeoxycholic acids were only found in P. verruculata. flavonoids, bile acids, and amino acid-betaine compounds were not reported before from onchidiidae, some are even new for panpulmonates. our chemical analyses indicate a close chemotaxonomic relation between phylogeographically distant Peronia species. Peronia Fleming, 1822, a panpulmonate slug genus, is typically distributed in tropical and subtropical regions of the Indo-Pacific ocean 1. The genus Peronia, with ten acknowledged species, has been reported from many localities ranging from the Indo-Pacific to the East Coast of Africa and to Hawaii 2-4. Due to undetected cryptic speciation, species diversity is often underestimated while the widespread distributions attributed to species is often overestimated 5. The integration of molecular and morphological methods has led to numerous discoveries of cryptic species complexes 6. This is also true for the genus Peronia, as was shown by Maniei et al. 3. To date, only three Peronia species are well investigated by molecular and/or morphology data, i.e.

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“…Consumption of Gen in the diet has been linked to decreased rates of metastatic cancer in a number of population-based studies [ 33 ]. In HCC, Gen has anti-mutagenic activity [ 34 ] and induces apoptosis [ 35 ]. In the present study, we showed for the first time that Gen suppresses TPA-induced cell invasive activity and MMP-9 expression by reducing tumor migration and invasion of HCC.…”

Section: Discussionmentioning

confidence: 99%

Genistein inhibits tumor invasion by suppressing multiple signal transduction pathways in human hepatocellular carcinoma cells

Wang

Chen

Kao

et al. 2014

BMC Complement Altern Med

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BackgroundGenistein (Gen) exhibits anti-mutagenic and anti-metastatic activities in hepatoma cell lines. Gen has suppressive effects on tumor growth and angiogenesis in nude mice. Gen suppresses the enzymatic activity of matrix metalloproteinase (MMP)-9; however, the mechanism underlying its anti-invasive activity on hepatocellular carcinoma (HCC) cells is unclear.MethodsIn this study, the possible mechanisms underlying Gen-mediated reduction of 12-O-Tetradecanoylphorbol-13-acetate (TPA)-induced cell invasion and inhibition of secreted and cytosolic MMP-9 production in human hepatoma cells (HepG2, Huh-7, and HA22T) and murine embryonic liver cells (BNL CL2) were investigated.ResultsGen suppressed MMP-9 transcription by inhibiting activator protein (AP)-1 and nuclear factor-κ B (NF-κB) activity. Gen suppressed TPA-induced AP-1 activity through inhibitory phosphorylation of extracellular signal-related kinase (ERK) and c-Jun N-terminal kinase (JNK) signaling pathways, and TPA-stimulated inhibition of NF-κB nuclear translocation through IκB inhibitory signaling pathways. Moreover, Gen suppressed TPA-induced activation of ERK/phosphatidylinositol 3-kinase/Akt upstream of NF-κB and AP-1.ConclusionsGen and its inhibition of multiple signal transduction pathways can control the invasiveness and metastatic potential of HCC.

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Chemoprotective activity of the isoflavones, genistein and daidzein on mutagenicity induced by direct and indirect mutagens in cultured HTC cells

Cited by 22 publications

References 46 publications

Quinoa Secondary Metabolites and Their Biological Activities or Functions

Quinoa Secondary Metabolites and Their Biological Activities or Functions

From Persian Gulf to Indonesia: interrelated phylogeographic distance and chemistry within the genus Peronia (Onchidiidae, Gastropoda, Mollusca)

Genistein inhibits tumor invasion by suppressing multiple signal transduction pathways in human hepatocellular carcinoma cells

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