Chemoprotective Effects of Zataria multiflora Against Genotoxicity Induced by Cyclophosphamide in Mice Bone Marrow Cells

Hosseinimehr, Seyed Jalal; Ahmadashrafi, Saeb; Naghshvar, Farshad; Ahmadi, Amirhossein; Ehasnalavi, Soheil; Tanha, Mohammad

doi:10.1177/1534735409360361

Cited by 28 publications

(30 citation statements)

References 18 publications

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“…The cellular and tissues toxicity were observed in the increased therapeutic dose of CP. We previously reported CP-induced oxidative stress and genotoxicity in mice bone marrow cells [22, 23]. We previously reported that CP increased the TBARS levels and therefore the extent of lipid peroxidation in the testis tissue of the experimental animals [24].…”

Section: Discussionmentioning

confidence: 99%

Prophylactic Efficacy of Melatonin on Cyclophosphamide-Induced Liver Toxicity in Mice

Shokrzadeh

Ahmadi

Naghshvar

et al. 2014

BioMed Research International

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The current study aimed to evaluate the protective effects of melatonin, a pineal secretory product, against hepatotoxicity induced by cyclophosphamide (CP) in mice. Mice were pretreated with melatonin intraperitoneally for 7 consecutive days before the administration of a single intraperitoneal dose of 200 mg/kg CP. 24 hr after CP administration, the mice were anesthetized, blood was then removed, and serum toxicity enzymes activities were evaluated. After the blood sampling, all animals were killed, livers were then removed, and histological studies were conducted. Serum toxicity marker enzymes were significantly increased after CP treatment but restored in melatonin pretreated groups. In addition, administration of CP induced necrotic hepatocyte with small crushed nuclei, portal space with severe inflammation, and hepatocytes surrounded by lymphocytic infiltration in hepatic tissues. However, melatonin effectively protected against CP-induced histopathological abnormalities in the liver tissues. Our results reveal that melatonin produces a potent hepatoprotective mechanism against CP. Therefore, melatonin could be a potent candidate to use concomitantly as a supplement agent against hepatotoxicity of CP for the patients undergoing chemotherapy.

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Section: Discussionmentioning

confidence: 99%

Prophylactic Efficacy of Melatonin on Cyclophosphamide-Induced Liver Toxicity in Mice

Shokrzadeh

Ahmadi

Naghshvar

et al. 2014

BioMed Research International

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“…Concentration-dependent effects of the extract also confirm anti-inflammatory effects of Z. multiflora . The effects of the three concentrations of the extract were studied according to the previous studies [36–41] and, using these concentrations, a plateau in the effect of the extract was not achieved.…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, the effect of the extract on other cytokines, inflammatory mediators, and biomarkers such as ED-1 should be examined in further studies. In the present study, the effects of only three concentrations of the extract were examined which were chosen based on the previous studies [36–41] which were insufficient for determination of IC50 for extracts and its effective dose. Therefore, IC50 for extracts and its effective dose should be examined in further studies.…”

Section: Discussionmentioning

confidence: 99%

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Effect of theZataria multifloraon Systemic Inflammation of Experimental Animals Model of COPD

Boskabady

Mhtaj

2014

BioMed Research International

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The effects of Zataria multiflora (Z. multiflora) on systemic inflammation in guinea pigs model of COPD were examined. Control animals, COPD (induced by exposing animals to cigarette smoke), COPD + drinking water containing three concentrations of the extract of Z. multiflora, and COPD + dexamethasone were studied (n = 6 for each group). Serum levels of IL-8 and malondialdehyde (MDA), total blood WBC (P < 0.01 for all cases), and eosinophil counts (P < 0.05) were higher and weight changes (P < 0.05) were lower in the COPD group compared to controls. IL-8 level (P < 0.001) and weight changes (P < 0.01 to P < 0.001) in all treated groups with Z. multiflora and total WBC number and MDA level in treated groups with two higher concentrations of the extract and lymphocytes percentage (P < 0.05) in the highest concentration of Z. multiflora and dexamethasone (P < 0.05 to P < 0.001) were significantly improved compared to the COPD group. Results showed a preventive effect of hydroethanolic extract from Z. multiflora on all measured parameters in animals model of COPD which was comparable or even higher (in the highest concentration) compared to the effect of dexamethasone at the concentration used.

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“…23,24 The bone marrow Mn test is a well-known in vivo assay for the assessment of genotoxicity in animals such as mice and rats. All groups treated with CP had the drug injected intraperitoneally, 25 while three type of honey was administered by Oral Intubation (O.I.)…”

Section: Mn Assaymentioning

confidence: 99%

Investigation of role magnetized water used in supplementary feeding for honeybees to modulate the genotoxic side effects induced by cyclophosphamide in mice bone marrow cells

Farhan¹,

Chechan

Alkinani

2017

J. contemp. med. sci.

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Objective To evaluate the possible protective role of honey formed through innovative way by using magnetized water instead of tab water in supplementary feeding for bees (HW) and compared with two honey types formed by two different feeding solutions; sugar syrup (HS) and nectar of flowers (HF) against cyclophosphamide (CP) genotoxicity in mice bone marrow cells, by using the micronucleus assay (MN). Methods Mice were divided into 8 groups from 3 animals each. G1 as control. G2 were exposed to CP (40 mg/kg), G3, G4, and G5 received two dose of three types of honey at doses (300, 600 mg/kg) respectively. The other groups G6, G7 and G8 were supplemented with three types honey (300 mg/kg) in three different experimental protocols, as pre 2 h, post 2 h, and concomitant treatment for 7 and 14 days. Results Examination and analysis of MN showed no mutagenic effect of three types honey per se doses, especially in low dose (300 mg/kg). Meanwhile, CP induced a significant (P < 0.01) increase in MN frequency. While dual treatment with groups of honey HW caused a significant reduction in MN induced by CP in bone marrow cells in a time-dependant manner. Also, the results confirmed the protective efficacy of HW group and/or HF group as compared with HS group, against CP-toxicity. Conclusion Our study suggests using magnetized water in supplementary feeding of bee, that could give the honey protective effect against genotoxicity induced by CP, it is also fosters antioxidant activity of honey constituents. Therefore, honey HW can be used as an adjuvant with chemotherapeutic agents for minimizing the genotoxic side effects of the anticancer drug CP.

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Chemoprotective Effects of Zataria multiflora Against Genotoxicity Induced by Cyclophosphamide in Mice Bone Marrow Cells

Cited by 28 publications

References 18 publications

Prophylactic Efficacy of Melatonin on Cyclophosphamide-Induced Liver Toxicity in Mice

Prophylactic Efficacy of Melatonin on Cyclophosphamide-Induced Liver Toxicity in Mice

Effect of theZataria multifloraon Systemic Inflammation of Experimental Animals Model of COPD

Investigation of role magnetized water used in supplementary feeding for honeybees to modulate the genotoxic side effects induced by cyclophosphamide in mice bone marrow cells

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