Chemoradionuclide Therapy with¹⁸⁶Re-labeled Liposomal Doxorubicin in Combination with Radiofrequency Ablation for Effective Treatment of Head and Neck Cancer in a Nude Rat Tumor Xenograft Model

Intrabiliary RF Heat-enhanced Local Chemotherapy of a Cholangiocarcinoma Cell Line: Monitoring with Dual-Modality Imaging—Preclinical Study

“…The biologic basis of hyperthermia-enhanced chemotherapy is perhaps associated with the mechanisms that hyperthermia can reverse chemotherapy resistance, increase oxygen radical production, and facilitate drug penetration and therefore uptake by cancer cells (7,10). Previous work (23) has revealed the potential usefulness of combining RF ablation with intravenous long-circulating temperature-sensitive liposomal doxorubicin to improve tumor growth control and decrease viable tumor. Increased drug deposition has also been observed, particularly in the tumor tissue surrounding the primary ablation zone (24).…”

Effect of thermal dose on heat shock protein expression after radio-frequency ablation with and without adjuvant nanoparticle chemotherapies

“…For example, eludcidation of hyperthermia-induced microvascular changes and increased vessel permeability in the periablational rim [13] directly has led to the successful combination of RF ablation with liposomal doxorubicin to increase targeted local drug delivery to tumors incompletely treated with ablation [14]. Characterization studies of this combination RF/Doxil paradigm demonstrated increases in tumor coagulation, animal endpoint survival, and intratumoral drug accumulation [15, 16, 17]. Similarly, characterization of apoptotic changes in the periablational rim, and reactive and protective heat shock protein expression (HSP70) have led to studies targeting these pathways as well to increase RF-induced tumor injury and animal endpoint survival [18,19].…”

Translational radionanomedicine: a clinical perspective

“…In vivo kinetics obtained by radiolabeled nanoparticles can provide radiation dosimetry as well as estimated concentration of chemical drugs in the target tissue. For example, 186 re-labeled liposomal doxorubicin could be applied to simultaneous local radiation and chemotherapy for tumor tissues (92). Dosimetry calculated by accumulation of the radiolabeled liposomes helps determine both radiation and chemotherapy doses for the treatment.…”