Chemoradiotherapy for locoregionally advanced squamous cell carcinoma of the base of tongue

Pederson, Aaron; Haraf, Daniel J.; Witt, Mary Ellyn; Stenson, Kerstin; Vokes, Everett E.; Blair, Elizabeth A.; Salama, Joseph K.

doi:10.1002/hed.21360

Cited by 22 publications

(20 citation statements)

References 53 publications

(42 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The rate of distant metastases in HPV+ patients can remain high, despite control of local disease. This is consistent with previous studies [14,18]. In our cohort, 4 (15.4%) out of 26 patients experienced distant recurrence, with the lung being the most common site of recurrence.…”

Section: Discussionsupporting

confidence: 93%

Adjuvant Radiation Therapy Alone for HPV Related Oropharyngeal Cancers with High Risk Features

Liu

Miles

et al. 2016

PLoS ONE

View full text Add to dashboard Cite

BackgroundCurrent standard of care for oropharyngeal cancers with positive surgical margins and/or extracapsular extension is adjuvant chemoradiotherapy. It is unknown whether HPV+ oropharyngeal cancer benefits from this treatment intensification.ObjectiveTo investigate the outcomes of HPV+ patients treated with adjuvant radiotherapy alone when chemoradiotherapy was indicated based on high risk pathological features. They were compared with high risk HPV+ patients treated with adjuvant chemoradiotherapy.MethodsAll high risk HPV+ oropharyngeal cancer patients (9) who received radiotherapy alone were identified. We also identified 17 patients who received chemoradiotherapy as a comparison group. Median follow up time was 37.3 months.ResultsNo local failures developed in adjuvant radiotherapy group. There was 1 distant recurrence in this cohort and 3 in CRT cohort. Regarding toxicity, 8 (47.1%) chemoradiotherapy patients had >10 lb. weight loss (p = 0.013), despite 75% of them having a percutaneous endoscopic gastrostomy tube placed. No individuals in radiotherapy group experienced a >10 lb. weight loss and none required a gastrostomy tube.ConclusionsThis series provides preliminary evidence suggesting that the omission of concurrent chemotherapy to adjuvant radiotherapy may offer comparative local control rates with a lower toxicity profile in the setting of HPV+ patients with traditional high risk features.

show abstract

Section: Discussionsupporting

confidence: 93%

Adjuvant Radiation Therapy Alone for HPV Related Oropharyngeal Cancers with High Risk Features

Liu

Miles

et al. 2016

PLoS ONE

View full text Add to dashboard Cite

show abstract

“…McDowell et al [20] concluded that chemoradiotherapy may be a reasonable alternative to surgery in patients with T4 tongue cancer, while Stenson et al [21] reported that systemic chemoradiotherapy in such patients may negate the need for total glossectomy. Pederson et al [22] reported that the rates of 5-year locoregional progression-free survival, overall survival, and disease-free survival in 127 patients with stage III or IV base of tongue cancer treated with systemic chemoradiotherapy was 87, 58.2, and 46 %, respectively. Concurrent chemoradiotherapy offers promising locoregional control for base of the tongue cancer [22].…”

Section: Discussionmentioning

confidence: 99%

“…Pederson et al [22] reported that the rates of 5-year locoregional progression-free survival, overall survival, and disease-free survival in 127 patients with stage III or IV base of tongue cancer treated with systemic chemoradiotherapy was 87, 58.2, and 46 %, respectively. Concurrent chemoradiotherapy offers promising locoregional control for base of the tongue cancer [22]. Another option for advanced tongue cancer is intra-arterial chemoradiotherapy, especially superselective intra-arterial infusion [17,23,24].…”

Section: Discussionmentioning

confidence: 99%

Squamous Cell Carcinoma of the Tongue Dorsum: Incidence and Treatment Considerations

Okubo

Iwai

Nakashima

et al. 2016

Indian J Otolaryngol Head Neck Surg

View full text Add to dashboard Cite

Squamous cell carcinoma (SCC) of the tongue is the most common oral cancer. Most cases occur on the lateral border of the tongue and only very rarely on the dorsum. We retrospectively investigated the incidence of SCC of the tongue dorsum in our department between April 2006 and March 2015. Of the 368 patients with tongue cancer, only 3 had SCC of the tongue dorsum (incidence, 0.8 %). All patients with advanced cancer of the tongue dorsum underwent superselective intra-arterial chemoradiotherapy for organ preservation. We discuss the present findings in relation to past case reports and series in the English language literature as well as discuss treatments for SCC of the tongue dorsum.

show abstract

“…For example, Denis et al reported that RT plus chemotherapy may be more effective than RT alone in the setting of advanced stage tumors. However, both RT alone and RT plus chemotherapy have been associated with long-term complications such as dysphagia and pharyngeal strictures [10, 11]. The more recent introduction of transoral surgical strategies has been temporally associated with an upswing in the proportion of patients receiving primary surgery [12].…”

Section: Introductionmentioning

confidence: 99%

Treatment selection in oropharyngeal cancer: a surveillance, epidemiology, and end results (SEER) patterns of care analysis

Pagedar

Chioreso

Schlichting

et al. 2017

Cancer Causes Control

View full text Add to dashboard Cite

Purpose Treatment for oropharyngeal cancer (OPC) has changed over the past two decades under multiple influences. We provide a population-based description of the application of radiotherapy, surgery, and chemotherapy to OPC in 1997, 2004 and 2009. Methods The National Cancer Institute’s Patterns of Care study for OPC included multiple variables not available in the public-use dataset. We identified factors correlating with selection of primary surgery versus radiotherapy with or without chemotherapy (RTC) and analyzed predictors of all-cause mortality. We estimated the frequency of human papillomavirus (HPV) testing. Results RTC was more common in 2009 than in 1997, and was more commonly applied to Stage IV cases. However, RTC was not an independent risk factor for mortality compared with surgery. HPV status was known in 14% of patients in 2009. Conclusions RTC is the most common treatment for OPC, but it may not provide the best outcomes. HPV testing was uncommon in 2009.

show abstract

Chemoradiotherapy for locoregionally advanced squamous cell carcinoma of the base of tongue

Abstract: Concurrent chemoradiotherapy results in promising locoregional control for base of tongue cancer. As distant relapse was common, further investigation of systemic therapy with novel agents may be warranted.

Cited by 22 publications

References 53 publications

Adjuvant Radiation Therapy Alone for HPV Related Oropharyngeal Cancers with High Risk Features

Adjuvant Radiation Therapy Alone for HPV Related Oropharyngeal Cancers with High Risk Features

Squamous Cell Carcinoma of the Tongue Dorsum: Incidence and Treatment Considerations

Treatment selection in oropharyngeal cancer: a surveillance, epidemiology, and end results (SEER) patterns of care analysis

Contact Info

Product

Resources

About