Chemoresistance and Metastasis in Breast Cancer Molecular Mechanisms and Novel Clinical Strategies

Cao, Ji; Zhang, Mengdi; Wang, Bin; Zhang, Long; Zhou, Fangfang; Fang, M.

doi:10.3389/fonc.2021.658552

Cited by 42 publications

(31 citation statements)

References 108 publications

(134 reference statements)

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“…Medication has a low clinical benefit in TNBC patients, therefore, finding molecular targets for TNBC treatment is essential for acquiring appropriate therapeutic targets. Several pathways can be targeted, including BRCA, Wnt/β-catenin, NF-κB, Hedgehog, JAK, PD-1/PD-L1, PI3K/Akt/m-TOR, EGFR [230,231], and others that have long been part of the treatment strategy. Finding new and effective treatment options for TNBC remains a critical clinical need.…”

Section: Future and Prospectsmentioning

confidence: 99%

Signaling Pathways and Natural Compounds in Triple-Negative Breast Cancer Cell Line

et al. 2022

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Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer, having a poor prognosis and rapid metastases. TNBC is characterized by the absence of estrogen, progesterone, and human epidermal growth receptor-2 (HER2) expressions and has a five-year survival rate. Compared to other breast cancer subtypes, TNBC patients only respond to conventional chemotherapies, and even then, with limited success. Shortages of chemotherapeutic medication can lead to resistance, pressured index therapy, non-selectivity, and severe adverse effects. Finding targeted treatments for TNBC is difficult owing to the various features of cancer. Hence, identifying the most effective molecular targets in TNBC pathogenesis is essential for predicting response to targeted therapies and preventing TNBC cell metastases. Nowadays, natural compounds have gained attention as TNBC treatments, and have offered new strategies for solving drug resistance. Here, we report a systematic review using the database from Pubmed, Science Direct, MDPI, BioScince, Springer, and Nature for articles screening from 2003 to 2022. This review analyzes relevant signaling pathways and the prospect of utilizing natural compounds as a therapeutic agent to improve TNBC treatments in the future.

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Section: Future and Prospectsmentioning

confidence: 99%

Signaling Pathways and Natural Compounds in Triple-Negative Breast Cancer Cell Line

et al. 2022

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“…As in other solid tumors, several studies reported a regulatory role for different miRNAs [ 84 , 85 ], and some miRNA expression profiles are associated with resistance to chemotherapy in breast tumors [ 86 , 87 ]. Zhou et al revealed that MCF7 breast cancer cells resistant to Adriamycin have significant over-expression of miR-29b-3p and miR-29b1-5p [ 88 ].…”

Section: Roles Of Mir-29b In Breast Cancermentioning

confidence: 99%

Mir-29b in Breast Cancer: A Promising Target for Therapeutic Approaches

2022

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The miR-29 family comprises miR-29a, miR-29b, and miR-29c, and these molecules play crucial and partially overlapped functions in solid tumors, in which the different isoforms are variously de-regulated and mainly correlated with tumor suppression. miR-29b is the most expressed family member in cancer, in which it is involved in regulating gene expression at both transcriptional and post-transcriptional levels. This review focuses on the role of miR-29b in breast cancer, in which it plays a controversial role as tumor suppressor or onco-miRNA. Here we have highlighted the dual effect of miR-29b on breast tumor features, which depend on the prevailing function of this miRNA, on the mature miR-29b evaluated, and on the breast tumor characteristics. Remarkably, the analyzed miR-29b form emerged as a crucial element in the results obtained by various research groups, as the most abundant miR-29b-3p and the less expressed miR-29b1-5p seem to play distinct roles in breast tumors with different phenotypes. Of particular interest are the data showing that miR-29b1-5p counteracts cell proliferation and migration and reduces stemness in breast tumor cells with a triple negative phenotype. Even if further studies are required to define exactly the role of each miR-29b, our review highlights its possible implication in phenotype-specific management of breast tumors.

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“…The advancement on knowledge of breast cancer and the use of personalized medicine, have greatly improved the prognosis and survival rates compared to previous decades [54]. However, as already mentioned, breast cancer continues to be the leading cause of cancer mortality in women, with 685,000 deaths only in 2020 [2], prompting researchers to conduct research on new treatments, especially for the advanced stages, presence of metastasis or cancer types with a poorer prognosis due to chemoresistance, such as triple-negative [55,56].…”

Section: Treatments and Prognosismentioning

confidence: 99%

Expression and Signaling Pathways of Nerve Growth Factor (NGF) And Pro-NGF in Breast Cancer: A Systematic Review

Bruno¹,

Arcuri²,

Vozzo³

et al. 2022

Preprint

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Breast cancer represents the most frequent cancer and the leading cause of cancer death among women. Thus, the prevention and early diagnosis of breast cancer appears to be of primary urgency as well as the development of new treatments able to improve its prognosis. Nerve Growth Factor (NGF) is a neurotrophic factor that plays a key role in the regulation of neuronal functions thought the binding to the Tropomyosin receptor kinase A (TrkA) and the Nerve Growth Factor receptor or Pan-Neurotrophin Receptor 75 (NGFR/p75NTR). Also, its precursor (pro-NGF) can extert biological activity by forming a trimeric complex with NGFR/p75NTR and sortilin or by binding to TrkA receptors with low affinity. Both in vitro and in vivo studies showed that NGF is synthesized and released by breast cancer cells and has mitogen, antiapoptotic and angiogenic effects on these cells through the activation of different signaling cascades that involve TrkA and NGFR/p75NTR receptors. Conversely, pro-NGF signaling has been related to breast cancer invasion and metastasis. Other studies suggested that NGF and its receptors could represent a good diagnostic and prognostic tool, as well as promising therapeutic targets for breast cancer. Here, we comprehensively summarize and systematically review the current experimental evidence on this topic.

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Chemoresistance and Metastasis in Breast Cancer Molecular Mechanisms and Novel Clinical Strategies

Cited by 42 publications

References 108 publications

Signaling Pathways and Natural Compounds in Triple-Negative Breast Cancer Cell Line

Signaling Pathways and Natural Compounds in Triple-Negative Breast Cancer Cell Line

Mir-29b in Breast Cancer: A Promising Target for Therapeutic Approaches

Expression and Signaling Pathways of Nerve Growth Factor (NGF) And Pro-NGF in Breast Cancer: A Systematic Review

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