Chemoselective Protection and Deprotection of Aldehydes Using Solid Supported Reagent (Silica Chloride) Under Solvent-Free Conditions

Abstract

Silica chloride, a heterogeneous catalyst, has been found to be an efficient catalyst for the protection of aldehydes as acylals under solvent-free conditions, and deprotection of acylals to aldehydes in methanol as a solvent occurred. The reaction takes a shorter time and ensures good to excellent yield of the products.