Chemosensitization and Radiosensitization of Tumors by Plant Polyphenols

Garg, Amit; Buchholz, Thomas A.; Aggarwal, Bharat B.

doi:10.1089/ars.2005.7.1630

Cited by 249 publications

(160 citation statements)

References 169 publications

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“…Among these, curcumin (2,3), and many other polyphenol derivatives (31,32,33,46,49,52,53,54) have been found to inhibit NF-B pathway in several tumor cell lines and at different levels, from I B phosphorylation to the expression of NF-B-regulated gene products. These novel findings could be of great importance in cancer prevention and therapy (27), especially in light of the latest evidence that demonstrates a pivotal role for NAD(P)H:quinone oxidoreductase 1 (NQO1) in producing ROS downstream of TNF engagement, in keratinocytes from NQO1 -/-mice (4). The genetic deletion of NQO1 used in this study abrogates the phosphorylative cascade mediated by MEKK1, which concomitantly activates I B kinase (IKK)/ NF-B signaling axis and all the members of the MAP kinase family: JNK, p38 MAPK , and p42/44 extracellular signalregulated kinase 1/2 (ERK1/2) (4).…”

Section: Redox-regulated Response To Cell Surface Receptors Engagementmentioning

confidence: 99%

Redox Control of Apoptosis: An Update

Filomeni

Ciriolo

2006

Antioxidants & Redox Signaling

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The redox environment of the cell is currently thought to be extremely important to control cell growth, differentiation, and apoptosis as many redox-sensitive proteins characterize these networks. A recent, widely accepted theory is that free radicals are not only dangerous species but, at low concentration, they have been designed by evolution to participate in the maintenance of cellular redox (reduction/oxidation) homeostasis. This notion derives from the evidence that cells constantly generate free radicals both as waste products of aerobic metabolism and in response to a large variety of stimuli. Free radicals, once produced, provoked cellular responses (redox regulation) against oxidative stress transducing the signals to maintain the cellular redox balance. Growing evidence suggests that in many instances the production of radical species is tightly regulated and their downstream targets are very specific, indicating that reactive oxygen species and reactive nitrogen species actively participate in several cell-signalling pathways as physiological "second messengers." In this review, we provide a general overview and novel insights into the redox-dependent pathways involved in programmed cell death.

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Section: Redox-regulated Response To Cell Surface Receptors Engagementmentioning

confidence: 99%

Redox Control of Apoptosis: An Update

Filomeni

Ciriolo

2006

Antioxidants & Redox Signaling

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“…Radiotherapy is the major therapeutic technique to minimize the effect of cervical cancer but due to its adverse effect on normal tissues, alternative plant-derived therapeutic drugs are being tested increasingly (Seiwert et al 2007). A large number of natural compounds have shown cytotoxic effects in different cancer models either alone or together with radiation (Garg et al 2005). Effects of FA on human cervical carcinoma cells ME-180 and HeLa have been studied and indicated that FA treatment significantly decreased radiation surviving fraction of the cancer cells and increased the lipid peroxidation indices (Subburayan et al 2011).…”

Section: Introductionmentioning

confidence: 99%

Characterization and anticancer potential of ferulic acid-loaded chitosan nanoparticles against ME-180 human cervical cancer cell lines

et al. 2015

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Ferulic acid (FA) is a widely distributed hydroxycinnamic acid found in various cereals and fruits exhibiting potent antioxidant and anticancer activities. However, due to low solubility and permeability, its availability to biological systems is limited. Non-toxic chitosan-tripolyphosphate pentasodium (CS-TPP) nanoparticles (NPs) are used to load sparingly soluble molecules and drugs, increasing their bioavailability. In the present work, we have encapsulated FA into the CS-TPP NPs to increase its potential as a therapeutic agent. Different concentrations of FA were tested to obtain optimum sized FA-loaded CS-TPP nanoparticles (FA/CS-TPP NPs) by ionic gelation method. Nanoparticles were characterized by scanning electron microscopy, Fourier transformation infrared spectroscopy (FTIR), thermogravimetric analyses and evaluated for their anticancer activity against ME-180 human cervical cancer cell lines. The FTIR spectra confirmed the encapsulation of FA and thermal analysis depicted its degradation profile. A concentration-dependent relationship between FA encapsulation efficiency and FA/ CS-TPP NPs diameter was observed. Smooth and spherical FA-loaded cytocompatible nanoparticles with an average diameter of 125 nm were obtained at 40 lM FA conc. The cytotoxicity of 40 lM FA/CS-TPP NPs against ME-180 cervical cancer cell lines was found to be higher as compared to 40 lM native FA. Apoptotic morphological changes as cytoplasmic remnants and damaged wrinkled cells in ME-180 cells were visualized using scanning electron microscopic and fluorescent microscopic techniques. Data concluded that chitosan enveloped FA nanoparticles could be exploited as an excellent therapeutic drug against cancer cells proliferation.

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“…Among nutraceuticals, polyphenols represent the most intriguing and studied class of compounds that can be therapeutics for a large spectrum of the most common diseases including cancer [20]. Nevertheless, despite several studies regarding their function, the anti-oxidant/prooxidant properties of these compounds remain somewhat debatable and the detailed molecular mechanisms of their effects continue to be largely unknown.…”

Section: Introductionmentioning

confidence: 99%

trans-Resveratrol induces apoptosis in human breast cancer cells MCF-7 by the activation of MAP kinases pathways

et al. 2007

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Polyphenols represent a large class of plantderived molecules with a general chemical structure that act as potent free radical scavengers. They have long been recognized to possess several therapeutic activities ranging from anti-thrombotic to antioxidant. Moreover, the capability of polyphenols to act as reducing or oxidizing molecules depends on the presence of environmental metals and on the concentrations used. In this work we demonstrated that the stilbene trans-resveratrol was able to commit human breast cancer MCF-7 cells to apoptosis. Mainly, we evidenced a pivotal role of the mitochondria in this phenomenon as cytochrome c release into the cytosol was found after the treatment. We further showed that trans-resveratrol was able to affect cellular redox state. In particular, it induced an early production of ROS and lipid oxidation, and only later compromised the GSH/GSSG ratio. This mode of action was mirrored by a temporally different activation of JNK and p38 MAPK , with the former rapidly induced and the latter weakly activated at long intervals. The results obtained demonstrate a pro-apoptotic activity for trans-resveratrol, and suggest a preferential activation of different classes of MAP kinases in response to different oxidative stimuli (ROS versus GSH/GSSG alteration).

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Chemosensitization and Radiosensitization of Tumors by Plant Polyphenols

Cited by 249 publications

References 169 publications

Redox Control of Apoptosis: An Update

Redox Control of Apoptosis: An Update

Characterization and anticancer potential of ferulic acid-loaded chitosan nanoparticles against ME-180 human cervical cancer cell lines

trans-Resveratrol induces apoptosis in human breast cancer cells MCF-7 by the activation of MAP kinases pathways

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