Chemosensitization of filamentous fungi to antifungal agents using Nectandra Rol. ex Rottb. species essential oils

Danielli, Letícia Jacobi; Pippi, Bruna; Soares, Krissie Daian; Duarte, Jonathaline Apollo; Maciel, Ana Julia; Machado, Michel Mansur; Oliveira, Luís Flávio Souza de; Bordignon, Sérgio A. L.; Apel, Miriam Anders

doi:10.1016/j.indcrop.2017.03.013

Cited by 21 publications

(27 citation statements)

References 34 publications

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“…shown that essential oils are capable of altering fungal cell permeability, facilitating entry of the antifungal agents into the cell, even increasing the intracellular amount of the drug available to exert its effect, resulting in more rapid fungal death. [4,5] Thus, the interaction characterized as additive observed for this fungal isolate may have been the result of this mechanism of action.…”

Section: Checkerboard Assaymentioning

confidence: 91%

Antichemotactic and Antifungal Action of the Essential Oils from Cryptocarya aschersoniana, Schinus terebinthifolia, and Cinnamomum amoenum

Maciel

Lacerda

Danielli

et al. 2019

Chemistry & Biodiversity

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The purpose of this work was to determine the chemical composition and evaluate the antichemotactic, antioxidant, and antifungal activities of the essential oil obtained from the species Cryptocarya aschersoniana Mez, Cinnamomum amoenum (Ness & Mart.) Kosterm., and Schinus terebinthifolia Raddi, as well as the combination of C. aschersoniana essential oil and terbinafine against isolates of dermatophytes. Allo‐aromadendrene, bicyclogermacrene, and germacrene B were identified as major compounds in essential oils. The essential oil of C. aschersoniana shown 100 % inhibitory effect on leukocyte migration at the concentration of 10 μg/mL while S. terebinthifolia oil presented 80.1 % inhibitory effect at the same concentration. Only S. terebinthifolia oil possessed free‐radical‐scavenging activity which indicates its antioxidant capacity. The essential oils were also tested against fungal isolates of dermatophyte species (Trichophyton rubrum, Trichophyton mentagrophytes, Microsporum canis and Microsporum gypseum), resulting in MIC ranging from 125 μg/mL to over 500 μg/mL. C. aschersoniana oil combined with terbinafine resulted in an additive interaction effect. In this case, the essential oil may act as a complement to conventional therapy for the topical treatment of superficial fungal infections, mainly because it is associated with an anti‐inflammatory effect.

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Section: Checkerboard Assaymentioning

confidence: 91%

Antichemotactic and Antifungal Action of the Essential Oils from Cryptocarya aschersoniana, Schinus terebinthifolia, and Cinnamomum amoenum

Maciel

Lacerda

Danielli

et al. 2019

Chemistry & Biodiversity

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“…This mechanism could be witnessed between the Nectandra lanceolata essential oil and ciclopirox (CIP) against dermatophytes (Danielli et al . ).…”

Section: Combination Of Antifungals With Natural Compoundsmentioning

confidence: 97%

“…These substances can stimulate healing of lesions and limit some symptoms related to cutaneous and subcutaneous fungal infections (Danielli et al . ). Thus, in a near future phytotherapy adjuvants should be part of the pharmaceutical industries’ available fungal infection treatments.…”

Section: Combination Of Antifungals With Natural Compoundsmentioning

confidence: 97%

“…(volatile oils; Danielli et al . ), and Artemisia sieberi (Mahboubi and Kazempour ) and Zataria multiflora essential oils (Mahboubi et al ., ). The mechanism was also affecting the fungal cell wall and membrane (Machado et al .…”

Section: Strategies To Combat Fungal Resistancementioning

confidence: 99%

“…; Danielli et al . ) is also an important antifungal therapy strategy. These substances can stimulate healing of lesions and limit some symptoms related to cutaneous and subcutaneous fungal infections (Danielli et al .…”

Section: Combination Of Antifungals With Natural Compoundsmentioning

confidence: 99%

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Antifungals discovery: an insight into new strategies to combat antifungal resistance

Fuentefría

Pippi

Lana

et al. 2018

Letters in Applied Microbiology

149

109

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Significance and Impact of the Study: The failure to respond to antifungal therapy is complex and is associated with microbiological resistance and increased expression of virulence in fungal pathogens. Thus, this review offers an overview of current challenges in the treatment of fungal infections associated with increased antifungal drug resistance and the formation of biofilms in these opportunistic pathogens. Furthermore, the most recent and potential strategies to combat fungal pathogens are explored here, focusing on new agents as well as innovative approaches, such as combination therapy between antifungal drugs or with natural compounds. AbstractUndeniably, new antifungal treatments are necessary against pathogenic fungi. Fungal infections have significantly increased in recent decades, being highlighted as important causes of morbidity and mortality, particularly in immunocompromised patients. Five main antifungal classes are used: (i) azoles, (ii) echinocandins, (iii) polyenes, (iv) allylamines and (v) pyrimidine analogues. Moreover, the treatment of mycoses has several limitations, such as undesirable side effects, narrow activity spectrum, a small number of targets and fungal resistance, which are still of major concern in clinical practice. The discovery of new antifungals is mostly achieved by the screening of natural or synthetic/semisynthetic chemical compounds. The most recent discoveries in drug resistance mechanism and their avoidance were explored in a review, focusing on different antifungal targets, as well as new agents or strategies, such as combination therapy, that could improve antifungal therapy.

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The Volatile Profiles and DNA Barcodes of Lauraceae Species from the Ocotea Complex with Occurrence in the Brazilian Amazon

Xavier

Trindade

Moreira

et al. 2022

Chemistry & Biodiversity

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The Ocotea complex accommodates most of the taxonomic diversity of Neotropical Lauraceae with economic importance and biological potential attributed to their essential oils (EOs) and extracts. However, the botanical taxonomy has had limitations due to the difficulty of identifying and delimiting species and genera. The chemical and molecular markers of Ocotea complex species in Pará state, Brazil, were assessed according to their EO compositions and DNA sequences of matK, trnL-trnF, and ITS regions. The multivariate analysis of EOs constituents has classified them into two main clusters characterized by oils rich in (I) terpenoids and phenylpropanoids and (II) sesquiterpenes. We conducted a phylogenetic analysis of species based on DNA barcode sequences on the Bayesian Inference (PP: 0.70 -1,0) and Maximum Likelihood (BS: 72 -100 %). The comparison between the volatile profiles and phylogenetic data indicates two main groups for these species collected from the Ocotea complex.

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Chemosensitization of filamentous fungi to antifungal agents using Nectandra Rol. ex Rottb. species essential oils

Cited by 21 publications

References 34 publications

Antichemotactic and Antifungal Action of the Essential Oils from Cryptocarya aschersoniana, Schinus terebinthifolia, and Cinnamomum amoenum

Antichemotactic and Antifungal Action of the Essential Oils from Cryptocarya aschersoniana, Schinus terebinthifolia, and Cinnamomum amoenum

Antifungals discovery: an insight into new strategies to combat antifungal resistance

The Volatile Profiles and DNA Barcodes of Lauraceae Species from the Ocotea Complex with Occurrence in the Brazilian Amazon

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