Chemostat-like microfluidic platform for highly sensitive detection of heavy metal ions using microbial biosensors

Kim, Minseok; Lim, Ji Won; Kim, Hyun Ju; Lee, Sung Kuk; Lee, Sang Jun; Kim, Taesung

doi:10.1016/j.bios.2014.10.028

Cited by 71 publications

(48 citation statements)

References 36 publications

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“…However, these methods have its disadvantages, such as energy wasting and the need for additional reagents to complete the separation process . The need for effective and efficient methods for the removal of heavy metal ions has resulted in the development of new separation technologies …”

Section: Introductionmentioning

confidence: 99%

Preparation of a novel modified ceramic membrane for removal of nickel ions from aqueous phase

Zeng

Qian

Zhang

et al. 2015

Asia-Pacific J Chem Eng

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A novel modified ceramic membrane (CM-SiO 2 -A) has been prepared with the depositing and grafting technologies for removal of Ni 2+ from aqueous solutions. Firstly, the silica was deposited onto the surface of initial ceramic membrane (CM) by using the in situ hydrolysis deposition method and activated to obtain the silanol groups. Then, 3-[2-(2aminoethylamino)ethylamino]propyl-trimethoxysilane was grafted onto the silica layer to obtain the CM-SiO 2 -A. The CM-SiO 2 -A was characterized by scanning electron microscopy, energy-dispersive X-ray spectroscopy, X-ray diffraction, Fourier transform-infrared spectroscopy, and thermogravimetric analysis. Further, the change of water flux and separation of Ni 2+ were studied by using the modified membrane. Results showed that the water flux of CM-SiO 2 -A was decreased by 84.79% compared with the CM. The CM-SiO 2 -A had a much higher total rejection rate of Ni 2+ (77.24%) than that of the un-grafted membrane (1.02%) at initial Ni 2+ concentration of 10 mg/L and exhibits the potential for separation of low concentration of Ni 2+ from aqueous solutions. Figure 1. Schematic diagram of ceramic membrane modification.Figure 3. SEM images of the surface of ceramic membranes: (a) initial ceramic membrane (CM); (b) ceramic membrane modified by grafting of AAAPTS (CM-SiO 2 -A).

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Section: Introductionmentioning

confidence: 99%

Preparation of a novel modified ceramic membrane for removal of nickel ions from aqueous phase

Zeng

Qian

Zhang

et al. 2015

Asia-Pacific J Chem Eng

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“…16 For a dual induction study, the same stain was transformed with plasmid pZBRG producing both red fluorescent proteins (RFPs) and GFPs in the presence of 40 mM arabinose and 10 μM tetracycline, respectively. 23 The same culture and preparation protocols as those used in our previous protocols 5, 24 were used for all the Analytical Chemistry Article DOI: 10.1021/acs.analchem.5b02028…”

Section: ■ Experimental Sectionmentioning

confidence: 99%

Crack-Photolithography for Membrane-Free Diffusion-Based Micro/Nanofluidic Devices

Kim

2015

Anal. Chem.

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Recent advances in controlling the cracking phenomena established a novel unconventional fabrication technique to generate mixed-scale patterns/structures with resolution and accuracy comparable to conventional nanofabrication techniques. Here, we adapt our previous cracking-assisted nanofabrication technique (called "crack-photolithography") relying on only the standard photolithography to develop micro/nanofluidic devices with greatly reduced time and cost. The crack-photolithography makes it possible not only to simultaneously produce micropatterns and nanopatterns with various dimensions but also to replicate both of the mixed-scale patterns in a high-throughput manner. Therefore, a microfluidic channel network can easily be fabricated with a nanochannel array that can function as a nanoporous membrane wherever necessary, which basically plays a key role in diffusion-allowed but convection-suppressed microfluidic devices. In addition, the nanochannel array can manipulate the transport of small molecules by adjusting its dimension and/or number at will, so that nanochannel-array-integrated micro/nanofluidic devices prove even more robust and accurate in diffusion control than conventional membrane-integrated microfluidic devices. As an application of such micro/nanofluidic devices, we employed synthetic bacterial cells and found that their genetic induction and expression are dominated by extracellular diffusive microenvironments that were completely engineered using the nanochannel array. Hence, the crack-photolithography could provide innovative fabrication techniques for unprecedented micro/nanofluidic devices that show substantial potential for a wide range of biological and chemical applications.

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“…For example, microbial fluorescence-based biosensor devices (Tao et al, 2013;Amaro et al, 2014) use reporter genes that react only when biochemical interactions occur between cellular reporters and inducer molecules. A combination of a chemostat-like microfluidic platform and microbial biosensors facilitates molecular analyte detection on a chip (Kim et al, 2015). For the rapid detection of heavy metal ions, a DNA optical biosensor combined with evanescent wave analysis can enable in-situ detection (Long et al, 2013).…”

Section: Biosensors For Heavy Metals Detectionmentioning

confidence: 99%

Biosensors and their Applications in Food Safety: A Review

Yasmin¹,

Ahmed²,

Cho³

2016

Journal of Biosystems Engineering

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Background: Foodborne pathogens are a growing concern with respect to human illnesses and death. There is an increasing demand for improvements in global food safety. However, it is a challenge to detect and identify these harmful organisms in a rapid, responsive, suitable, and effective way. Results: Rapid developments in biosensor designs have contributed to the detection of foodborne pathogens and other microorganisms. Biosensors can automate this process and have the potential to enable fast analyses that are cost and time-effective. Various biosensor techniques are available that can identify foodborne pathogens and other health hazards. Conclusions: In this review, biosensor technology is briefly discussed, followed by a summary of foodborne pathogen detection using various transduction systems that exhibit specificity for particular foodborne pathogens. In addition, the recent application of biosensor technology to detect pesticides and heavy metals is briefly addressed.

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Chemostat-like microfluidic platform for highly sensitive detection of heavy metal ions using microbial biosensors

Cited by 71 publications

References 36 publications

Preparation of a novel modified ceramic membrane for removal of nickel ions from aqueous phase

Preparation of a novel modified ceramic membrane for removal of nickel ions from aqueous phase

Crack-Photolithography for Membrane-Free Diffusion-Based Micro/Nanofluidic Devices

Biosensors and their Applications in Food Safety: A Review

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