Chemosurgical Reports: Management of Verrucous Carcinoma on a Foot by a Combination of Chemosurgery and Plastic Repair: Report of a Case

Mallatt, Bruce D.; Ceilley, Roger I.; Dryer, Randall F.

doi:10.1111/j.1524-4725.1980.tb00913.x

Cited by 11 publications

(3 citation statements)

References 6 publications

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“…25,56 The efficacy of MMS is well documented for tumors with contiguous growth and enables maximum preservation of normal tissue structure and function with complete margin visualization. Thus, our results are in agreement with those of prior studies, [54][55][56]64 suggesting that MMS is associated with lower recurrence rates for EC than WLE. Future studies and reporting of MMS for EC are particularly important because of the functional importance of the plantar foot.…”

Section: Commentsupporting

confidence: 93%

“…Both traditional MMS on fresh tissue and "slow Mohs," with formalinfixed paraffin embedded tissue examination over several days, were performed for EC with horizontal en face sectioning. [54][55][56] Incidence of recurrence was reported for 86% (12/14) of MMS cases. Of these, recurrence was seen in 17% (2/12) that utilized a flat horizontal processing of tissue sections coupled with saucerlike excisions to enable examination of the entire undersurface and margins.…”

Section: Treatment Modalitiesmentioning

confidence: 99%

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Epithelioma Cuniculatum (Plantar Verrucous Carcinoma): A Systematic Review of Treatment Options

Daniel¹

2023

Cutis

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CLINICAL REVIEWEpithelioma cuniculatum (EC) is a subtype of verrucous carcinoma (VC) that affects the feet. Treatment involves complete tumor removal by wide local excision (WLE) or Mohs micrographic surgery (MMS). Extensive local destruction may require amputation. We sought to compare reported treatment methods for EC and determine their efficacy by assessing for tumor recurrence and treatment-associated complications. A systematic review of the literature spanning multiple databases was performed. To date, surgical excision is recommended as the standard of care for treatment of EC, with amputation considered in more advanced cases. Mohs micrographic surgery appears to be a promising treatment modality for EC and may have lower recurrence rates than WLE but requires further investigation.Cutis. 2023;111:E19-E24.V errucous carcinoma (VC) is an uncommon type of well-differentiated squamous cell carcinoma (SCC) that most commonly affects men in the fifth to sixth decades of life. 1 The tumor grows slowly over a decade or more and does not frequently metastasize but has a high propensity for recurrence and local invasion. 2 There are 3 main subtypes of VC classified by anatomic site: oral florid papillomatosis (oral cavity), Buschke-Lowenstein tumor (anogenital region), and epithelioma cuniculatum (EC)(feet). 3 Epithelioma cuniculatum, also known as carcinoma cuniculatum or papillomatosis cutis carcinoides, most commonly presents as a solitary, warty or cauliflowerlike, exophytic mass with keratin-filled sinus tracts and malodorous discharge. 4 Diabetic foot ulcers and chronic inflammatory conditions are predisposing risk factors for EC, and it can result in difficulty walking/immobility, pain, and bleeding depending on anatomic involvement. [5][6][7][8][9] The differential diagnosis for VC includes refractory verruca vulgaris, clavus, SCC, keratoacanthoma, deep fungal or mycobacterial infection, eccrine poroma or porocarcinoma, amelanotic melanoma, and sarcoma. [10][11][12][13] The slow-growing nature of VC, sampling error of superficial biopsies, and minimal cytological atypia on histologic examination can contribute to delayed diagnosis and appropriate treatment. 14 Characteristic histologic features include hyperkeratosis, papillomatosis, marked acanthosis, broad blunt-ended rete ridges with a "bulldozing" architecture, and minimal cytologic atypia and mitoses. 5,6

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Section: Commentsupporting

confidence: 93%

Section: Treatment Modalitiesmentioning

confidence: 99%

Epithelioma Cuniculatum (Plantar Verrucous Carcinoma): A Systematic Review of Treatment Options

Daniel¹

2023

Cutis

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“…A total of 80 scholarly articles were identified in the PubMed search. Only 50 of the 80 articles met our inclusion criteria 5,22-25,31-68,70-76 : confirmed histopathological diagnosis of verrucous carcinoma or epithelioma cuniculatum. A total of 64 cases were available for analysis.…”

Section: Literature Reviewmentioning

confidence: 99%

Atypical Presentation of Verrucous Carcinoma

Penera

Manji²,

Craig³

et al. 2013

Foot & Ankle Specialist

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Plantar verrucous carcinoma (epithelioma cuniculatum): Case report with review of the literature

Kathuria

Rieker

Jablokow

et al. 1986

Journal of Surgical Oncology

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Verrucous carcinoma is a rare highly keratinizing variant of squamous cell carcinoma that is a slow-growing, locally aggressive, and rarely metastasizing tumor. It may involve various body sites including oral, genital, and plantar areas. The tumor has a characteristic gross appearance with multiple sinuses opening on the surface and may present a difficult diagnostic problem. Multiple biopsies and close clinical correlation are frequently required before a definite diagnosis is possible. The differential diagnosis is especially difficult if only fragments or superficial portions of the lesion are submitted for histological evaluation. Reviewing surgical material from our institution from 1976 to 1983, we located four cases of verrucous carcinoma of the foot. These four cases were diagnosed on the bases of clinical, gross, and microscopic appearances. One of the cases had bilateral lesions. One of the cases is described with review of the literature.

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Chemosurgical Reports: Management of Verrucous Carcinoma on a Foot by a Combination of Chemosurgery and Plastic Repair: Report of a Case

Cited by 11 publications

References 6 publications

Epithelioma Cuniculatum (Plantar Verrucous Carcinoma): A Systematic Review of Treatment Options

Epithelioma Cuniculatum (Plantar Verrucous Carcinoma): A Systematic Review of Treatment Options

Atypical Presentation of Verrucous Carcinoma

Plantar verrucous carcinoma (epithelioma cuniculatum): Case report with review of the literature

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