Chemotaxis of Polymorphonuclear Leukocytes from Patients with Diabetes Mellitus

Mowat, A G; Baum, John

doi:10.1056/nejm197103252841201

Cited by 676 publications

(237 citation statements)

References 26 publications

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“…Although insulin is reported to have effects in all of these cells (19,(21)(22)(23)(24)(25), it is not known whether insulin plays a physiologic role in their metabolic control, especially since the concentrations of insulin that have been effective in vitro far surpass those that occur in vivo.…”

Section: Binding Of [Mlalinsulin To Fibroblastsmentioning

confidence: 99%

Insulin Receptors in Human Circulating Cells and Fibroblasts

Gavin¹,

Roth²,

Jen³

et al. 1972

Proc. Natl. Acad. Sci. U.S.A.

209

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Human lymphocytes obtained from fasted adult subjects and cultured human tumor lymphocytes were investigated for specific insulin receptors. By use of monoiodoinsulin, specific insulin binding sites were demonstrated in peripheral human lymphocytes, cultured human lymphocytes, and in other types of human circulating cells. Insulins and insulin derivatives that varied in their potency to stimulate glucose oxidation in the fat cell and to inhibit binding of [ 125 I]insulin to purified plasma membranes, varied in an analogous fashion in their ability to inhibit the binding of labeled insulin to human lymphocytes. Hormones that had no effect on the binding of insulin to fat cells or liver membranes also had no effect on the binding of insulin to lymphocytes. Binding was time and temperature dependent; dissociation of [ 125 I]insulin was rapid upon addition of 10 μM insulin. These findings afford a direct approach to the study of endocrine disorders in man.

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Section: Binding Of [Mlalinsulin To Fibroblastsmentioning

confidence: 99%

Insulin Receptors in Human Circulating Cells and Fibroblasts

Gavin¹,

Roth²,

Jen³

et al. 1972

Proc. Natl. Acad. Sci. U.S.A.

209

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“…A number of studies shows that diabetic animals present a decreased response to intradermally administered bradykinin and vasoactive amines as well as swelling induced by dextran, carrageenan, and cellulose sulphate, indicating alteration in the microcirculatory reactivity (Garcia-Leme et al 1974, Fortes et al 1984, Akamine et al 2003. Moreover, neutrophils from diabetics have also been shown to present functional abnormalities such as less phagocytizing capacity (Wertman & Henney 1962) and chemotactic responses (Mowat & Baum 1971, Fortes et al 1991, Mello et al 1992, which might be extended to other inflammatory cells as those involved in allergic processes.…”

mentioning

confidence: 99%

Mast cell changes in experimental diabetes: focus on attenuation of allergic events

Carvalho

Barreto

Cordeiro

et al. 2005

Mem. Inst. Oswaldo Cruz

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“…Mucormycosis is an opportunistic fulminating fungal infection of the sinonasal region fi rst described by Plataut AP in 1885 [6]. Patients having diabetic ketoacidosis, leukemia, prolonged corticosteroid therapy, deferroxamine therapy are more prone for the development of mucormycosis [7][8][9][10]. Both the mononuclear and polymorphonuclear phagocytes of normal host kills mucorales by the generation of oxidative metabolites and cationic peptides [11].…”

Section: Discussionmentioning

confidence: 99%

Hard palate perforation in acute lymphoblastic leukemia due to mucormycosis — a case report

Samanta

Senapati

Kumar

et al. 2009

Indian J Hematol Blood Transfus

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Palatal perforation can occur due to trauma, infection and malignancy. Mucormycosis is a rare opportunistic fungal infection caused by an organism of class zygomycetes. Rhinocerebral mucormycosis is the most common type of mucormycosis that typically starts in maxillary antrum in immunocompromised patients. Invasion of surrounding structures leads to necrotizing ulcer of the hard palate and ultimately leads to perforation. Here, we report a case of perforation of the hard palate due to mucormycosis in a eight years child having acute lymphoblastic leukemia (ALL), who was on prolonged chemotherapy and corticosteroid therapy. This case is being reported for its rarity. The aim of presenting this case report is to emphasize that the infection due to mucomycosis should be included in the differential diagnosis of hard palate perforation in ALL patients who are immunocompromised.

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Chemotaxis of Polymorphonuclear Leukocytes from Patients with Diabetes Mellitus

Cited by 676 publications

References 26 publications

Insulin Receptors in Human Circulating Cells and Fibroblasts

Insulin Receptors in Human Circulating Cells and Fibroblasts

Mast cell changes in experimental diabetes: focus on attenuation of allergic events

Hard palate perforation in acute lymphoblastic leukemia due to mucormycosis — a case report

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