Chemotaxis of polymorphonuclear leukocytes to varicella-zoster virus antigens

Piracy on the molecular level: human herpesviruses manipulate cellular chemotaxis

“…The known receptor for CXCL9 is CXCR3, which is expressed predominantly in non-resting T cells (Van Raemdonck et al, 2015). Expression has also been observed in epithelial, endothelial, fibroblast and smooth muscle cells (SMCs) (Billottet et al, 2013;Van Raemdonck Past research has also suggested that VZV could utilize glycoproteins as chemoattractants, inducing migration of polymorphonuclear leukocytes (Ihara et al, 1991). No other recent research has been conducted to determine if VZV affects chemotaxis of other infected cell types, although several studies do provide evidence for how VZV might influence cellular chemotaxis (Desloges et al, 2008;Shavit et al, 1999;Steain et al, 2011).…”