Chemotaxonomic significance of 5-deoxyproanthocyanidins in Stryphnodendron species

Lopes, Gisely Cristiny; Machado, Fátima Aparecida Vieira; Toledo, Cleyton Eduardo Mendes de; Sakuragui, Cássia Mônica; Mello, João Carlos Palazzo de

doi:10.1016/j.bse.2008.10.004

Cited by 19 publications

(23 citation statements)

References 23 publications

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“…The bark of S. adstringens is rich in proanthocyanidin polymers, including several flavan-3-ols, such as prodelphinidins and prorobinetinidins [19–22]. The chemical composition of prodelphinidin (F2) has been partially defined as a heptamer compound [16].…”

Section: Introductionmentioning

confidence: 99%

Acute and Chronic Toxicity of an Aqueous Fraction of the Stem Bark ofStryphnodendron adstringens(Barbatimão) in Rodents

Costa

Mello

Kaneshima

et al. 2013

Evidence-Based Complementary and Alternative Medicine

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Stryphnodendron adstringens has a high tannin content and is used as an antiseptic and antimicrobial and in the treatment of leucorrhea, gonorrhea, wound healing, and gastritis. The present study evaluated the toxic effects of the heptamer prodelphinidin (F2) from the stem bark of S. adstringens in rodents. In the acute toxicity test, the mice that received oral doses exhibited reversible effects, with an LD50 of 3.015 mg · kg−1. In the chronic toxicity test at 90 days, Wistar rats were treated with different doses of F2 (10, 100, and 200 mg · kg−1). In the biochemical, hematological, and histopathological examinations and open-field test, the different dose groups did not exhibit significant differences compared with controls. The present results indicate that F2 from the stem bark of S. adstringens caused no toxicity with acute and chronic oral treatment in rodents at the doses administered.

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Section: Introductionmentioning

confidence: 99%

Acute and Chronic Toxicity of an Aqueous Fraction of the Stem Bark ofStryphnodendron adstringens(Barbatimão) in Rodents

Costa

Mello

Kaneshima

et al. 2013

Evidence-Based Complementary and Alternative Medicine

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“…Coville, Fabaceae, known as 'barbatimão', occurs in the central savannah region of Brazil and is a rich source of tannins (Santos et al, 2002) and proanthocyanidins (Mello et al, 1996a;1996b;Ishida et al, 2006;Lopes et al, 2008). Stem bark is the main part of the plant used popularly as an anti-infl ammatory, astringent, in the treatment of wounds and vaginal infections (Panizza et al, 1988;Lopes et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

Protective action against chemical-induced genotoxicity and free radical scavenging activities of Stryphnodendron adstringens ("barbatimão") leaf extracts

Filho¹,

Ferreira²,

Gouvêa³

2011

Rev. bras. farmacogn.

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The present study describes for the first time the antigenotoxic and antioxidant properties of Stryphnodendron adstringens (Mart.) Coville, Fabaceae ("barbatimão") leaves. The aqueous (AEB), water fraction (WFB) and ethanolic (EEB) extracts of leaves were obtained and they presented high content of phenolic compounds, flavonoids and proanthocyanidins. WFB and EEB inhibited the genotoxicity induced by cyclophosphamide. WFB inhibited the DNA lesion formation and both WFB and EEB decreased significantly (p<0.05) micronucleus formation. All extracts also showed high DPPH radical scavenging activity and reducing power. In conclusion all extracts presented antioxidant activity and WFB and EEB protected cells from genotoxicity induced by cyclophosphamide in rat bone marrow cells. Thus, our results support the beneficial effects of the barbatimão extracts as an anticarcinogenic agent.

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“…Its bark is popularly used in Brazil for wound healing and in the treatment of leukorrhea [2], and it is rich in condensed tannins, with a content of at least 8% [3]. Flavan-3-ols, prodelphinidins, and prorobinetidins have also been isolated from the bark [4][5][6][7]. The bark has been evaluated for several activities, including anti-inflammatory [8], antibacterial [9], antifungal [10,11], antiulcerogenic [12], trypanocidal [13], and antinociceptive [14].…”

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confidence: 99%

Stryphnodendron adstringens: Clarifying Wound Healing in Streptozotocin-Induced Diabetic Rats

et al. 2015

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Diabetes mellitus is a serious public health problem in which a major complication is impaired wound healing. Among the strategies developed to foster tissue repair is the use of medicinal plants. The bark of Stryphnodendron adstringens, which is popularly used as an aid in wound healing, has a documented effect on wound repair in normal rats. This study evaluated the healing action of the crude extract of S. adstringens in diabetic rats, and its chemical content. Compounds present in the crude extract were characterized by mass spectrometry. In diabetic rats (streptozotocin 35 mg/kg), two wounds made in the skin were treated daily for 4, 7, 10, and 14 days with gel containing 1 % crude extract or with base gel. Histological analyses involved the measurement of the length and thickness of the re-epithelialized surface, quantification of the number of cells in mitosis, and types I and III collagen fibers. Also, cutaneous permeation by photoacoustic spectroscopy, and the expression of cyclooxygenase-2 and vascular endothelial growth factor by Western blot were assessed. The crude extract fingerprint showed masses indicating proanthocyanidins. The crude extract mainly stimulated cell migration and proliferation of keratinocytes at the beginning of the treatment in addition to stimulating the replacement of type III collagen fibers by type I collagen fibers at 10 and 14 days. The photoacoustic spectroscopy technique showed that the gel containing 1 % of crude extract permeated through the skin to the dermis, where the crude extract was found. Vascular endothelial growth factor was stimulated after 7 days of treatment with the crude extract and cyclooxygenase-2 at 4, 7, and 10 days. The crude extract of S. adstringens acted in tissue repair in wounds in diabetic rats by stimulating the production of collagen fibers at the wound site. The crude extract favored the formation of a more organized extracellular matrix and filled the entire extent of the wound, and also fostered the upregulation of cyclooxygenase-2 and vascular endothelial growth factor, which are essential to this process. These crude extract actions in diabetic wounds are probably due to the presence of proanthocyanidins.

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Chemotaxonomic significance of 5-deoxyproanthocyanidins in Stryphnodendron species

Cited by 19 publications

References 23 publications

Acute and Chronic Toxicity of an Aqueous Fraction of the Stem Bark ofStryphnodendron adstringens(Barbatimão) in Rodents

Acute and Chronic Toxicity of an Aqueous Fraction of the Stem Bark ofStryphnodendron adstringens(Barbatimão) in Rodents

Protective action against chemical-induced genotoxicity and free radical scavenging activities of Stryphnodendron adstringens ("barbatimão") leaf extracts

Stryphnodendron adstringens: Clarifying Wound Healing in Streptozotocin-Induced Diabetic Rats

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