Chemotherapeutic Activity of 5-Fluorocytosine Against a Lethal
            <i>Candida albicans</i>
            Infection in Mice

Fifty lactobacilli isolated from black table olive brines were evaluated for their salt tolerance, resistance to oleuropein and verbascoside, and ability to grow in modified filter-sterilized brines. A strain of Lactobacillus pentosus was selected and used as a starter to ferment, in pilot plant, black olives (Itrana and Leccino cv.) in brines modified for pH, carbohydrate, and growth factor concentrations, at 28 degrees C. The temperature-controlled fermentation of Leccino cv. olives resulted in obtaining ready-to-eat, high-quality table olives in a reduced-time process. HPLC analysis of phenolic compounds from fermented olives showed a decrease of oleuropein, a glucoside secoiridoid responsible for the bitter taste of olive drupes, and an increase of the hydroxytyrosol concentration. The selected strain of L. pentosus (1MO) allowed the reduction of the debittering phase period to 8 days.

show abstract

Chemotherapeutic Activity of 5-Fluorocytosine Against a Lethal Candida albicans Infection in Mice

Abstract: Numerous strains of Candida were inhibited by low concentrations of 5-fluorocytosine in vitro. Marked increase in life span occurred in C. albicans -infected mice treated with 5-fluorocytosine.

Cited by 12 publications

References 5 publications

DectiSomes: C-type lectin receptor-targeted liposomes as pan-antifungal drugs

DectiSomes: C-type lectin receptor-targeted liposomes as pan-antifungal drugs

Chapter 13. Antifungal Agents

The Use ofLactobacillus pentosus1MO To Shorten the Debittering Process Time of Black Table Olives (Cv. Itrana and Leccino): A Pilot-Scale Application

Contact Info

Product

Resources

About