Chemotherapeutic efficacy of curcumin and resveratrol against cancer: Chemoprevention, chemoprotection, drug synergism and clinical pharmacokinetics

Patra, Srimanta; Pradhan, Biswajita; Nayak, Rabindra; Behera, Chhandashree; Rout, Laxmidhar; Jena, Mrutyunjay; Efferth, Thomas; Bhutia, Sujit K.

doi:10.1016/j.semcancer.2020.10.010

Cited by 105 publications

(88 citation statements)

References 99 publications

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“…To cite some examples, in vitro assays reported that curcumin exerted anticancer effects (reduction of cell proliferation, cell cycle arrest, apoptosis, autophagy, etc.) in different cells lines, such as human endometrial, malignant glioma, malignant mesothelioma, breast adenocarcinoma, melanoma, chronic myelogenous leukemia or gastric cancer cell lines [116,[121][122][123][124]. In vivo studies have reported similar results, for example, in chronic myeloid leukemia [123], pancreatic cancer [125] or breast cancer mice models [126].…”

Section: Curcuminmentioning

confidence: 80%

“…Similarly, resveratrol inhibited cell proliferation, induced the apoptosis and suppressed the angiogenesis and metastasis in bladder cancer micemodels [113]. Resveratrol has been also reported to enhance the efficacy of traditional chemotherapeutic drugs, including temozolomide, doxorubicin and paclitaxel in mice models [114][115][116].…”

Section: Resveratrolmentioning

confidence: 96%

“…However, one of the main drawbacks of resveratrol is its low water-solubility, which limits its clinical use. To overcome this limitation, some strategies have been considered such as synthesis of novel derivatives and analogues [116], micro-formulation [78] or nano-delivery systems [117].…”

Section: Resveratrolmentioning

confidence: 99%

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Status and Challenges of Plant-Anticancer Compounds in Cancer Treatment

et al. 2021

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Nowadays, cancer is one of the deadliest diseases in the world, which has been estimated to cause 9.9 million deaths in 2020. Conventional treatments for cancer commonly involve mono-chemotherapy or a combination of radiotherapy and mono-chemotherapy. However, the negative side effects of these approaches have been extensively reported and have prompted the search of new therapeutic drugs. In this context, scientific community started to look for innovative sources of anticancer compounds in natural sources, including traditional plants. Currently, numerous studies have evaluated the anticancer properties of natural compounds derived from plants, both in vitro and in vivo. In pre-clinical stages, some promising compounds could be mentioned, such as the sulforaphane or different phenolic compounds. On the other hand, some phytochemicals obtained positive results in clinical stages and were further approved for cancer treatment, such as vinca alkaloids or the paclitaxel. Nevertheless, these compounds are not exempt of limitations, such as low solubility, restricted effect on their own, negative side-effects, etc. This review aims to compile the information about the current phytochemicals used for cancer treatment and also promising candidates, main action mechanisms and also reported limitations. In this sense, some strategies to face the limitations have been considered, such as nano-based formulations to improve solubility or chemical modification to reduce toxicity. In conclusion, although more research is still necessary to develop more efficient and safe phytochemical drugs, more of these compounds might be used in future cancer therapies.

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Section: Curcuminmentioning

confidence: 80%

Section: Resveratrolmentioning

confidence: 96%

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Status and Challenges of Plant-Anticancer Compounds in Cancer Treatment

et al. 2021

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“…Diet plays an important role in disease prevention as more than 33% of diseases, such as cancer, diabetes, and inflammation-associated chronic diseases, could be avoided by changing lifestyle and food habits [19,20]. Nutritional supplements from natural sources could also play an important role in preventing diseases.…”

Section: Biological Activities Of Marine Algae and Potential Health Bmentioning

confidence: 99%

“…Algal bioactive metabolites and their functional role in diabetes are summarized in Table 2. Brown algae E. cava Dieckol α-Glucosidase inhibitor [20]; postprandial hyperglycemia-lowering effect [7]; glucose uptake effect in skeletal muscle [40]; PTP 1B inhibition [10]; protective effect against diabetes complication [139,140,154,155]…”

Section: Significance Of Marine Algal Bioactive Metabolites As Anti-dmentioning

confidence: 99%

Bioactive Metabolites from Marine Algae as Potent Pharmacophores against Oxidative Stress-Associated Human Diseases: A Comprehensive Review

et al. 2020

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In addition to cancer and diabetes, inflammatory and ROS-related diseases represent one of the major health problems worldwide. Currently, several synthetic drugs are used to reduce oxidative stress; nevertheless, these approaches often have side effects. Therefore, to overcome these issues, the search for alternative therapies has gained importance in recent times. Natural bioactive compounds have represented, and they still do, an important source of drugs with high therapeutic efficacy. In the “synthetic” era, terrestrial and aquatic photosynthetic organisms have been shown to be an essential source of natural compounds, some of which might play a leading role in pharmaceutical drug development. Marine organisms constitute nearly half of the worldwide biodiversity. In the marine environment, algae, seaweeds, and seagrasses are the first reported sources of marine natural products for discovering novel pharmacophores. The algal bioactive compounds are a potential source of novel antioxidant and anticancer (through modulation of the cell cycle, metastasis, and apoptosis) compounds. Secondary metabolites in marine Algae, such as phenolic acids, flavonoids, and tannins, could have great therapeutic implications against several diseases. In this context, this review focuses on the diversity of functional compounds extracted from algae and their potential beneficial effects in fighting cancer, diabetes, and inflammatory diseases.

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Comparison of PLLA‐PEG and PDLLA‐PEG micelles for co‐encapsulation of docetaxel and resveratrol

Jurczyk,

Musiał‐Kulik,

Foryś

et al. 2023

J Biomed Mater Res

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The interest in combining chemosensitizers with cytostatics in cancer therapy is growing, which causes also a need to develop their delivery systems. Example of the combination with beneficial therapeutic effects is docetaxel (Dtx) and resveratrol (Res). Although poly(lactide)‐co‐poly(ethylene glycol) (PLA–PEG) micelles have been considered as one of the most promising platforms for drug delivery, their properties may depend on the stereoisomeric form of hydrophobic block. Therefore, the aim of this study was evaluation of the effect of PLA block on co‐encapsulation and release rate of Dtx and Res, which has not been studied so far. This article presents a comparison of single‐ (Dtx or Res) and dual‐drug (Dtx and Res) loaded micelles obtained from poly(l,l‐lactide)‐co‐poly(ethylene glycol) (PLLA‐PEG) and poly(d,l‐lactide)‐co‐poly(ethylene glycol) (PDLLA‐PEG). The analyzes of the micelles have been conducted including morphology, drug(s) encapsulation efficiency, intermolecular interactions, in vitro drug release, and cytotoxicity. Differences in drug loading ability and release profile have been observed between Res and Dtx but also depending on the polymer and number of drugs in micelles (single vs. dual loaded). The PLLA‐PEG micelles have a significantly higher Dtx encapsulation capacity than PDLLA‐PEG micelles. The highest cytotoxicity was shown for Dtx and Res dual‐loaded micelles, regardless of the polymer. The findings may be used for selection of PLA‐based drug delivery systems containing Dtx and Res.

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Chemotherapeutic efficacy of curcumin and resveratrol against cancer: Chemoprevention, chemoprotection, drug synergism and clinical pharmacokinetics

Cited by 105 publications

References 99 publications

Status and Challenges of Plant-Anticancer Compounds in Cancer Treatment

Status and Challenges of Plant-Anticancer Compounds in Cancer Treatment

Bioactive Metabolites from Marine Algae as Potent Pharmacophores against Oxidative Stress-Associated Human Diseases: A Comprehensive Review

Comparison of PLLA‐PEG and PDLLA‐PEG micelles for co‐encapsulation of docetaxel and resveratrol

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