Chemotherapeutic Interventions Targeting HIV Interactions with Host-Associated Carbohydrates

Synthesis and characterization of sugar-based methacrylates and their random copolymers by ATRP

“…Due to the recently developed controlled polymerization techniques and click chemistry reactions, synthesis of tailor-made glycopolymers has become simpler and their biological properties can be easily adjusted as a function of the type of attached carbohydrates [42][43][44]. For instance, a series of phenylboronic acid-based block and random glycopolymers were prepared by RAFT polymerization and their self-assembled and drug-delivery properties were systematically studied [45].…”

Preparation and antiherpetic activities of chemically modified polysaccharides from Polygonatum cyrtonema Hua

“…In particular, the antiviral effect of polysaccharides against the herpes simplex virus (HSV) has been reported (Arad, Ginsberg, & Huleihel, 2006;Damonte, Matulewicz, & Cerezo, 2004;Karmakar, Pujol, Damonte, Tuhin Ghosh, & Ray, 2010;Luescher-Mattli, 2003;Pujol, Carlucci, Matulewicz, & Damonte, 2007) and some of these polysaccharides are currently undergoing either preclinical or clinical evaluation (Kleymann, 2005;McReynolds & Garvey-Hague, 2007). Unlike the widely used acyclovir (ACV)-related nucleoside analogues, which all targeted against viral DNA synthesis, polysaccharides interfere with the attachment of virus to host cell surface by binding to viral envelope glycoprotein (Damonte et al, 2004;Duarte et al, 2001;Neyts et al, 1992;Witvrouw & De Clercq, 1997).…”

Polymeric Anti‐HIV Therapeutics

“…A review by McReynolds and GervayHague provides an excellent overview of (modified)-polysaccharides that exhibit anti-HIV activity mostly as entry inhibitors. [75] …”