Chemotherapy and Anti-Epileptic Drug Interactions

Fink, Karen

doi:10.1016/b978-012088410-0/50041-x

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Cited by 4 publications

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“…Valproate is frequently used to treat childhood epilepsy. Prophylactic use of antiepileptic drugs (AED) in brain tumor patients has been discouraged [2], but a recent meta-analysis was not conclusive [3]. We decided to give prophylactic AED to newly diagnosed children with brain tumors because of local issues [4].…”

Section: Introductionmentioning

confidence: 99%

Survival of children with malignant brain tumors receiving valproate: a retrospective study

et al. 2012

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These results do not prove that valproate prophylactic treatment in pediatric patients with malignant brain tumors had an influence on their survival. However, our cohort showed an effect of higher size than the recent European Organization for Research and Treatment of Cancer trial analysis, even though not significant. Clinical trials with valproate in pediatric malignant brain tumors should be carefully planned, in order to detect a possible effect of this drug in survival.

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Section: Introductionmentioning

confidence: 99%