Chemotherapy as an Aid in the Management of Acute Osteomyelitis

Penberthy, Grover C.; Weller, Charles N.

doi:10.1097/00000658-194107000-00014

Cited by 10 publications

(6 citation statements)

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“…A total course of 20 days for OM and OM+SA, and 10-14 days in SA suffices in most cases [3,[9][10][11]. Sometimes, even a shorter course may heal the patient [49], but no randomized study has assessed these 'ultra-short' treatments.…”

Section: Five-year Viewmentioning

confidence: 99%

Simplifying the treatment of acute bacterial bone and joint infections in children

Pääkkönen

Peltola

2011

Expert Review of Anti-infective Therapy

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The treatment of acute hematogenous bone and joint infections of children - osteomyelitis (OM), septic arthritis (SA) and OM-SA combination (OM+SA) - has simplified over the past years. The old approach included months-long antibiotic treatment, started intravenously for at least a week, followed by oral completion of the course. Recent prospective randomized trials show that most cases heal with a total course of 3 weeks (OM, OM+SA) or 2 weeks (SA) of an appropriate antibiotic, provided the clinical response is good and C-reactive protein level has normalized. If the prevalence of methicillin-resistant Staphylococcus aureus and Kingella kingae is low, clindamycin and a first-generation cephalosporin are safe, inexpensive and effective alternatives. They should be administered in large doses and four times a day. Clindamycin, vancomycin and expensive linezolid are options against methicillin-resistant Staphylococcus aureus. Extensive surgery beyond a diagnostic sample by aspiration is rarely needed in uncomplicated cases.

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Section: Five-year Viewmentioning

confidence: 99%

Simplifying the treatment of acute bacterial bone and joint infections in children

Pääkkönen

Peltola

2011

Expert Review of Anti-infective Therapy

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“…No less than 70 years ago, Penberthy and Weller showed that AHOM sometimes healed with a 3-day course of sulphonamides [11]. However, the fact that the A c c e p t e d M a n u s c r i p t 5 infection was cured did not necessarily imply that the entire disease process was over.…”

Section: Important Distinction Between Infection and Inflammationmentioning

confidence: 99%

“…Historically, it is of interest that no good data support the necessity of this practice, provided the patient tolerates the oral route, a well absorbed agent and exceptionally large doses (Table 1) [11]. However, in those days a surgical intervention was done routinely.…”

Section: Intravenous Versus Oral Administrationmentioning

confidence: 99%

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Antibiotic treatment for acute haematogenous osteomyelitis of childhood: Moving towards shorter courses and oral administration

Pääkkönen¹,

Peltola²

2011

International Journal of Antimicrobial Agents

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“…In reality, the treatment took one to three months, sometimes longer. Interestingly, clinicians seem to have forgotten that the first successful treatments with sulphonamides in late 1930s only lasted a few days and the administration was mostly oral . However, the symptoms could flare up again, and this was one of the reasons that longer periods of treatment became commonplace.…”

mentioning

confidence: 99%