Chemotherapy as the definitive form of therapy in esophageal carcinoma

Nelson, Cyril S.

doi:10.1016/s0022-5223(19)41857-6

Cited by 5 publications

(1 citation statement)

References 2 publications

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“…The advantages of operative management, however, are more rapid palliation of symptoms, possible cure, and absence of distressing complications brought about by irradiation. Chemotherapy as a primary mode of treatment has been used rarely so that there is a paucity of reports and data [2].…”

mentioning

confidence: 99%

Results of resection of carcinoma of the esophagus and cardia in 196 patients

Orel¹,

Eržen²,

Hrabar³

1981

World j. surg.

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During the period 1962–1976, 196 patients were operated on for carcinoma of the esophagus (51) and cardia (145). In all patients resection with primary esophagogastrostomy or esophagojejunostomy was performed. Metastases involving the regional lymph nodes were found in 54.2% of patients. The early postoperative mortality rate was 21.9%. The most common cause of death was leakage at the esophagogastric anastomosis (46.5% of deaths). Mean survival period was 16.2 months, overall 5‐year survival rate was 18.7%, and 5‐year survival rate excluding early post‐operative mortality was 21.7%. Mean survival period in patients who had resection of the esophagus with negative lymph nodes was 13.5 months and in those with positive nodes was 8.1 months. Mean survival time in patients after resection of the cardia was 19.7 months if nodes were negative and 8.2 months if nodes were positive. The most frequent cause of late death was advanced cancer and distant metastases. Postoperatively, most patients were able to adopt their previous mode of life. All living patients but 1 are ambulatory, 2/3 perform work that is the same as or easier than that prior to the onset of the illness, they have no difficulty in consuming food, and are physically fit. The most common side effect was heartburn due to reflux esophagitis.

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mentioning

confidence: 99%

Results of resection of carcinoma of the esophagus and cardia in 196 patients

Orel¹,

Eržen²,

Hrabar³

1981

World j. surg.

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Combined modality therapy for esophageal squamous cell carcinoma

Franklin

Steiger

Vaishampayan

et al. 1983

Cancer

134

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Of 55 patients with esophageal squamous cell carcinoma, 30 with localized disease were treated with a combined modality for curative intent. Treatment consisted of mitomycin C (10 mg/m2 day 1) and continuous infusion 5‐FU (1000 mg/m2 day, days 1–4, 29–32) (CT), radiation (XRT) (3000 rad, days 1–21) with nutritional support, and surgery (days 49–64). Surgery consisted of celiotomy, esophagectomy and esophagogastrostomy ± postoperative ventilatory support. Postoperative CT plus an additional 2000 rad XRT was restricted to patients with histologic positive tumor. Since five resected patients with subclinical metastatic tumor had an inferior survival equal to 25 patients treated essentially for palliation, pretreatment celiotomy seems warreanted to identify patients with an inferior prognosis. Of 18 resected patients without disseminated tumor evaluable for this combined modality: six were tumor free, three had intramural and nine transmural tumor; the median survival is 76 weeks and five of six living patients are disease free at 95–190 weeks; and local recurrence occurred in two and in two of seven unresected patients. Since toxicity was minimal except for postoperative pneumonitis (13%) and local recurrence low (13%), two courses of chemotherapy and 5000 rad XRT perhaps obviates the need for resection.

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Esophageal Carcinoma

Just-Viera

Silva

1975

The Annals of Thoracic Surgery

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Chemotherapy as the definitive form of therapy in esophageal carcinoma

Cited by 5 publications

References 2 publications

Results of resection of carcinoma of the esophagus and cardia in 196 patients

Results of resection of carcinoma of the esophagus and cardia in 196 patients

Combined modality therapy for esophageal squamous cell carcinoma

Esophageal Carcinoma

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