Chemotherapy Combined With Surgery in a Case With Metanephric Adenoma

Abstract

BackgroundMetanephric adenoma is an extremely rare renal neoplasm, especially in pediatrics. Chemotherapy combined with surgery in metanephric adenoma has not been reported.MethodsWe describe a case of metanephric adenoma in a child less than 2 years old, which were treated by chemotherapy combined with surgery.ResultsNephron sparing surgery was performed after regular chemotherapy, and the pathological result was metanephric adenoma.ConclusionPediatric metanephric adenoma is extremely rare; the clinical manifestations and imaging examinations lack specificity. Nephron sparing surgery is recommended as the preferred treatment for metanephric adenoma. Long-term follow-up and more in-depth molecular genetic research are still needed to determine the benign or malignant of metanephric adenoma and whether chemotherapy drugs have an effect on it.

Metanephric adenoma in children: A case report and literature review

“…The disease can occur at any age but is more common in women aged 50–60 years ( 32 ). The incidence of MA in children is extremely rare ( 9 , 31 ), with only 27 cases reported in the literature before the present study. Most of the patients with MA have no obvious clinical symptoms and they often seek medical treatment after a physical examination or incidental findings.…”

“…Intraoperative frozen pathological examination can clarify the diagnosis and aid in selection of an appropriate surgical method, which is an ideal diagnostic tools that can minimize the occurrence of missed diagnosis and mistreatment and avoid the need to perform a total nephrectomy ( 17 ). A previous study reported that MA can be treated with a chemotherapy regimen also used to treat WT ( 9 ). Overall, MA has a good prognosis and even with a small number of cases of malignant MA reported in previous studies, no recurrence has been reported during follow-up ( 8 , 19 , 50 ).…”

Metanephric adenoma managed with robotic partial nephrectomy: A case report

“…Metanephric adenomas arise from metanephric cells and are associated with maturing nephroblastomas, or Wilm's tumors (WTs). Reports have described them as being more common in women (2:1) and generally arising in adults age 50-70 [2], although there have been reports of pediatric MAs in children as young as 15 months [3]. Metanephric adenomas are benign and have a favorable prognosis [4].…”