Chemotherapy

Topological properties and in vitro identification of essential nodes of the Paclitaxel and Vincristine interactomes in PC-3 cells

“…Prostate cancer has become the most common malignancy among men and is the second leading cause of cancer death worldwide [8], [9]. Prostate cancer is very heterogeneous, often characterized by the presence of AR-dependent and AR-independent cellular clones in the same patient [10], its biological, hormonal, and molecular characteristics are extremely complex [6].…”

“…Since its growth is driven by androgens, they are primarily treated with hormonal therapy, the androgen ablation therapy (ADT), that aims to block or decrease the expression of the androgen receptor, the hormonal therapy is the standard treatment of hormone-naïve metastatic disease [11], [12], [13]. Nearly all patients with metastatic prostate cancer (PC) become resistant to the initial approach with ADT, developing the state known as metastatic castration-resistant prostate cancer (mCRPC) [10].…”